MCL coexpression mm9:424

Phase1 CAGE Peaks

	Short description
Mm9::chr11:118277114..118277138,-	p3@Cant1
Mm9::chr11:58192538..58192554,+	p1@2210415F13Rik
Mm9::chr11:58196298..58196316,+	p@chr11:58196298..58196316 +
Mm9::chr14:8849148..8849194,+	p@chr14:8849148..8849194 +
Mm9::chr17:23990719..23990747,+	p1@Prss32
Mm9::chr18:20716778..20716781,+	p4@Dsg2
Mm9::chr1:135101254..135101286,+	p@chr1:135101254..135101286 +
Mm9::chr3:122215088..122215124,+	p@chr3:122215088..122215124 +
Mm9::chr4:119310297..119310302,+	p3@Guca2a
Mm9::chr4:119310309..119310326,+	p1@Guca2a
Mm9::chr4:119310332..119310344,+	p2@Guca2a
Mm9::chr4:119311395..119311417,-	p@chr4:119311395..119311417 -
Mm9::chr5:114593479..114593491,+	p@chr5:114593479..114593491 +
Mm9::chr5:117769350..117769361,+	p4@Vsig10
Mm9::chr5:143573837..143573852,+	p@chr5:143573837..143573852 +
Mm9::chr5:23934066..23934086,+	p8@Slc4a2
Mm9::chr5:4023343..4023357,+	p@chr5:4023343..4023357 +
Mm9::chr7:52976553..52976603,+	p1@Fam83e

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004382	guanosine-diphosphatase activity	0.0126006683832795
GO:0045134	uridine-diphosphatase activity	0.0126006683832795
GO:0009191	ribonucleoside diphosphate catabolic process	0.0251654610230754
GO:0009185	ribonucleoside diphosphate metabolic process	0.0251654610230754
GO:0009134	nucleoside diphosphate catabolic process	0.0251654610230754
GO:0009261	ribonucleotide catabolic process	0.0251654610230754
GO:0005452	inorganic anion exchanger activity	0.0251654610230754
GO:0017110	nucleoside-diphosphatase activity	0.0251654610230754
GO:0015380	anion exchanger activity	0.0251654610230754
GO:0015106	bicarbonate transmembrane transporter activity	0.0251654610230754
GO:0015301	anion:anion antiporter activity	0.0251654610230754
GO:0015108	chloride transmembrane transporter activity	0.0251654610230754
GO:0009132	nucleoside diphosphate metabolic process	0.0251654610230754
GO:0030057	desmosome	0.0251654610230754
GO:0009166	nucleotide catabolic process	0.0368769999257902
GO:0004263	chymotrypsin activity	0.0413854539292577
GO:0015103	inorganic anion transmembrane transporter activity	0.0413854539292577
GO:0004295	trypsin activity	0.0432598518775996

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
intestinal epithelial cell	8.32e-12	9
epithelial cell of alimentary canal	8.32e-12	9
brush border epithelial cell	7.94e-09	6
gut absorptive cell	7.94e-09	6
absorptive cell	7.94e-09	6
enterocyte	7.94e-09	6
columnar/cuboidal epithelial cell	2.22e-07	7

Uber Anatomy

Ontology term	p-value	n
intestine	2.24e-32	31
gastrointestinal system	4.77e-32	47
mucosa	1.25e-19	15
intestinal mucosa	5.60e-17	13
anatomical wall	5.60e-17	13
wall of intestine	5.60e-17	13
gastrointestinal system mucosa	5.60e-17	13
organ component layer	1.59e-14	24
epithelium of mucosa	8.32e-12	9
gastrointestinal system epithelium	8.32e-12	9
intestinal epithelium	8.32e-12	9
endoderm-derived structure	3.24e-11	118
endoderm	3.24e-11	118
presumptive endoderm	3.24e-11	118
digestive system	3.07e-10	116
digestive tract	3.07e-10	116
primitive gut	3.07e-10	116
simple columnar epithelium	3.31e-09	11
subdivision of digestive tract	6.37e-09	114

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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