MCL coexpression mm9:396

Phase1 CAGE Peaks

	Short description
Mm9::chr11:106161584..106161590,+	p@chr11:106161584..106161590 +
Mm9::chr11:106161724..106161753,+	p@chr11:106161724..106161753 +
Mm9::chr11:106161754..106161757,-	p@chr11:106161754..106161757 -
Mm9::chr11:106162417..106162448,+	p@chr11:106162417..106162448 +
Mm9::chr11:106162437..106162476,-	p@chr11:106162437..106162476 -
Mm9::chr11:106162783..106162832,-	p@chr11:106162783..106162832 -
Mm9::chr12:3960439..3960482,-	p@chr12:3960439..3960482 -
Mm9::chr1:74116782..74116807,-	p@chr1:74116782..74116807 -
Mm9::chr5:141592278..141592283,+	p@chr5:141592278..141592283 +
Mm9::chr5:152202814..152202825,+	p@chr5:152202814..152202825 +
Mm9::chr6:126485282..126485295,-	p5@Kcna5
Mm9::chr6:55326278..55326345,+	p1@Ghrhr
Mm9::chr6:55326368..55326373,+	p2@Ghrhr
Mm9::chr7:109017720..109017744,-	p13@Folr1
Mm9::chr8:10695076..10695087,-	p@chr8:10695076..10695087 -
Mm9::chr9:36592402..36592409,-	p@chr9:36592402..36592409 -
Mm9::chrX:46846282..46846291,+	p@chrX:46846282..46846291 +
Mm9::chrX:46846293..46846316,+	p@chrX:46846293..46846316 +
Mm9::chrX:46846319..46846351,+	p@chrX:46846319..46846351 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0033143	regulation of steroid hormone receptor signaling pathway	2.48515736428866e-05
GO:0030518	steroid hormone receptor signaling pathway	0.000322834473186431
GO:0030522	intracellular receptor-mediated signaling pathway	0.000422013907469306
GO:0040018	positive regulation of multicellular organism growth	0.000477728983046277
GO:0045927	positive regulation of growth	0.000537546397969296
GO:0040014	regulation of multicellular organism growth	0.00182418535003343
GO:0035264	multicellular organism growth	0.00215647132584364
GO:0046655	folic acid metabolic process	0.00592923897665471
GO:0006810	transport	0.00592923897665471
GO:0051234	establishment of localization	0.00592923897665471
GO:0040008	regulation of growth	0.00592923897665471
GO:0051179	localization	0.00592923897665471
GO:0019870	potassium channel inhibitor activity	0.00592923897665471
GO:0016520	growth hormone-releasing hormone receptor activity	0.00592923897665471
GO:0015459	potassium channel regulator activity	0.00592923897665471
GO:0005131	growth hormone receptor binding	0.00592923897665471
GO:0060133	somatotropin secreting cell development	0.00592923897665471
GO:0060126	somatotropin secreting cell differentiation	0.00657318122251631
GO:0004999	vasoactive intestinal polypeptide receptor activity	0.00657318122251631
GO:0060124	positive regulation of growth hormone secretion	0.00657318122251631
GO:0043267	negative regulation of potassium ion transport	0.00657318122251631
GO:0006620	posttranslational protein targeting to membrane	0.00657318122251631
GO:0043567	regulation of insulin-like growth factor receptor signaling pathway	0.00657318122251631
GO:0048878	chemical homeostasis	0.00731979991158991
GO:0043271	negative regulation of ion transport	0.00746522188833836
GO:0008517	folic acid transporter activity	0.00746522188833836
GO:0060123	regulation of growth hormone secretion	0.00746522188833836
GO:0043266	regulation of potassium ion transport	0.00868725972802251
GO:0046887	positive regulation of hormone secretion	0.00868725972802251
GO:0046903	secretion	0.00889093507082687
GO:0030252	growth hormone secretion	0.00889093507082687
GO:0021984	adenohypophysis development	0.00889093507082687
GO:0008200	ion channel inhibitor activity	0.00889093507082687
GO:0016248	channel inhibitor activity	0.00889093507082687
GO:0008340	determination of adult life span	0.00953093980484191
GO:0030104	water homeostasis	0.00953093980484191
GO:0051183	vitamin transporter activity	0.00953093980484191
GO:0051184	cofactor transporter activity	0.010333063439317
GO:0018987	osmoregulation	0.010333063439317
GO:0042592	homeostatic process	0.0105840667053847
GO:0009966	regulation of signal transduction	0.0107720578324596
GO:0048009	insulin-like growth factor receptor signaling pathway	0.0107934737471018
GO:0051047	positive regulation of secretion	0.0111923120760308
GO:0010259	multicellular organismal aging	0.0111923120760308
GO:0005542	folic acid binding	0.0111923120760308
GO:0006760	folic acid and derivative metabolic process	0.0120429111558723
GO:0043269	regulation of ion transport	0.0128571384581254
GO:0042558	pteridine and derivative metabolic process	0.013637267237792
GO:0016247	channel regulator activity	0.0148072675954601
GO:0007595	lactation	0.0148072675954601
GO:0015457	auxiliary transport protein activity	0.0148072675954601
GO:0051051	negative regulation of transport	0.016777432247842
GO:0021983	pituitary gland development	0.016777432247842
GO:0001633	secretin-like receptor activity	0.016777432247842
GO:0005886	plasma membrane	0.0170756255971267
GO:0045047	protein targeting to ER	0.0170756255971267
GO:0046883	regulation of hormone secretion	0.0173531113338805
GO:0021536	diencephalon development	0.0173531113338805
GO:0005615	extracellular space	0.0179942877363719
GO:0030879	mammary gland development	0.0184491084075961
GO:0044421	extracellular region part	0.0206153037467956
GO:0006612	protein targeting to membrane	0.0210171090287721
GO:0015758	glucose transport	0.0210171090287721
GO:0008645	hexose transport	0.0210171090287721
GO:0030072	peptide hormone secretion	0.0210171090287721
GO:0015749	monosaccharide transport	0.0210171090287721
GO:0007568	aging	0.0210171090287721
GO:0002790	peptide secretion	0.0213231929639771
GO:0065008	regulation of biological quality	0.0213231929639771
GO:0005802	trans-Golgi network	0.0229825851491478
GO:0007189	G-protein signaling, adenylate cyclase activating pathway	0.0247770458774296
GO:0030141	secretory granule	0.0261276503101051
GO:0015833	peptide transport	0.0261276503101051
GO:0005126	hematopoietin/interferon-class (D200-domain) cytokine receptor binding	0.0261276503101051
GO:0006767	water-soluble vitamin metabolic process	0.0261276503101051
GO:0046879	hormone secretion	0.0271016582580552
GO:0042391	regulation of membrane potential	0.0273998672993993
GO:0035270	endocrine system development	0.0308974249675608
GO:0051046	regulation of secretion	0.0330376439919835
GO:0048518	positive regulation of biological process	0.0330477049552734
GO:0008076	voltage-gated potassium channel complex	0.0330477049552734
GO:0006752	group transfer coenzyme metabolic process	0.0330477049552734
GO:0007188	G-protein signaling, coupled to cAMP nucleotide second messenger	0.0332514267076892
GO:0007187	G-protein signaling, coupled to cyclic nucleotide second messenger	0.0346391528393976
GO:0019933	cAMP-mediated signaling	0.0354062112259137
GO:0008643	carbohydrate transport	0.0357394729419819
GO:0006766	vitamin metabolic process	0.0357394729419819
GO:0019935	cyclic-nucleotide-mediated signaling	0.0359002829273947
GO:0046483	heterocycle metabolic process	0.0371780650177166
GO:0050878	regulation of body fluid levels	0.0386745083598179
GO:0048609	reproductive process in a multicellular organism	0.0386745083598179
GO:0032504	multicellular organism reproduction	0.0386745083598179
GO:0048469	cell maturation	0.0392875422895539
GO:0048732	gland development	0.0392875422895539
GO:0007242	intracellular signaling cascade	0.0392875422895539
GO:0042445	hormone metabolic process	0.0420259705949108
GO:0050794	regulation of cellular process	0.0420259705949108
GO:0005249	voltage-gated potassium channel activity	0.0424011550696585
GO:0051049	regulation of transport	0.0424750640880743
GO:0003001	generation of a signal involved in cell-cell signaling	0.0435413653632095
GO:0021700	developmental maturation	0.0450775106007803
GO:0030900	forebrain development	0.0490137829712046

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
pituitary gland	1.66e-54	8
gland of diencephalon	1.66e-54	8
neuroendocrine gland	1.66e-54	8
diencephalon	8.43e-44	10
future diencephalon	8.43e-44	10
regional part of forebrain	8.52e-12	39
forebrain	8.52e-12	39
future forebrain	8.52e-12	39
anterior neural tube	1.62e-11	40
regional part of brain	4.29e-10	46
brain	6.83e-10	47
future brain	6.83e-10	47
pre-chordal neural plate	1.64e-09	49
neural tube	5.37e-09	52
neural rod	5.37e-09	52
future spinal cord	5.37e-09	52
neural keel	5.37e-09	52
regional part of nervous system	1.10e-08	54
endocrine gland	7.20e-08	60
neurectoderm	2.08e-07	64
neural plate	2.08e-07	64
presumptive neural plate	2.08e-07	64
gland	2.65e-07	65

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}