Coexpression cluster:C617

Full id: C617_mucinous_gall_signet_bile_maxillary_keratoacanthoma_Alveolar

Phase1 CAGE Peaks

Hg19::chr10:88106150..88106156,+	p@chr10:88106150..88106156 +
Hg19::chr11:70781237..70781270,-	p@chr11:70781237..70781270 -
Hg19::chr13:99644885..99644901,+	p@chr13:99644885..99644901 +
Hg19::chr14:102196739..102196744,+	p1@LINC00239
Hg19::chr16:16011740..16011741,-	p@chr16:16011740..16011741 -
Hg19::chr16:52028463..52028468,-	p@chr16:52028463..52028468 -
Hg19::chr16:52028472..52028487,-	p@chr16:52028472..52028487 -
Hg19::chr16:52028503..52028515,-	p@chr16:52028503..52028515 -
Hg19::chr1:240996509..240996525,-	p@chr1:240996509..240996525 -
Hg19::chr20:62321640..62321645,+	p1@BC131817
Hg19::chr5:172722414..172722417,-	p@chr5:172722414..172722417 -
Hg19::chr6:31080343..31080359,-	p1@C6orf15
Hg19::chr7:55757275..55757282,-	p1@FKBP9L
Hg19::chr7:73118172..73118185,-	p3@STX1A

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0050796	regulation of insulin secretion	0.0214651323421493
GO:0030073	insulin secretion	0.0214651323421493
GO:0046883	regulation of hormone secretion	0.0214651323421493
GO:0030072	peptide hormone secretion	0.0214651323421493
GO:0002790	peptide secretion	0.0214651323421493
GO:0005484	SNAP receptor activity	0.0274245201189629
GO:0046879	hormone secretion	0.0274245201189629
GO:0015833	peptide transport	0.0275212931074951
GO:0051046	regulation of secretion	0.0369868979872323
GO:0003001	generation of a signal involved in cell-cell signaling	0.0394816897354447
GO:0006836	neurotransmitter transport	0.0399850147348268

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

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Cell Type

Ontology term	p-value	n
epithelial cell	4.30e-23	254
endo-epithelial cell	5.04e-14	43
endodermal cell	3.82e-12	59
respiratory epithelial cell	1.73e-08	13
epithelial cell of lung	1.24e-07	19

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	6.04e-12	169
endoderm	6.04e-12	169
presumptive endoderm	6.04e-12	169
respiratory tract	9.64e-12	53
respiratory system	2.16e-10	72
digestive system	3.18e-10	155
digestive tract	3.18e-10	155
primitive gut	3.18e-10	155
mixed endoderm/mesoderm-derived structure	4.87e-10	130
respiratory system epithelium	8.44e-10	28
foregut	2.09e-09	98
subdivision of digestive tract	2.20e-09	129
endodermal part of digestive tract	2.20e-09	129
segment of respiratory tract	7.29e-09	46
anatomical space	8.18e-09	104
thoracic cavity element	1.19e-08	34
thoracic cavity	1.19e-08	34
lung	1.61e-08	22
respiratory tube	1.61e-08	22
respiration organ	1.61e-08	22
pair of lungs	1.61e-08	22
lung primordium	1.61e-08	22
lung bud	1.61e-08	22
endo-epithelium	2.16e-08	82
thoracic segment organ	3.95e-08	35
epithelial bud	5.24e-08	37
trunk region element	7.69e-08	107
immaterial anatomical entity	1.13e-07	126
respiratory tract epithelium	1.24e-07	19
lung epithelium	1.24e-07	19
respiratory primordium	2.01e-07	38
endoderm of foregut	2.01e-07	38

Disease

Ontology term	p-value	n
carcinoma	1.17e-18	106
cell type cancer	2.33e-17	143
cancer	3.27e-10	235
disease of cellular proliferation	7.51e-10	239
squamous cell carcinoma	2.80e-08	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
NR3C1#2908	4	4.27800666604944	0.0115683845516382	0.0422873023061334

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.