Coexpression cluster:C98: Difference between revisions
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Latest revision as of 10:30, 17 September 2013
Full id: C98_CD8_Natural_Basophils_blood_CD4_Peripheral_Whole
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
p.value | FDR | nGenes | nPathway | Name |
---|---|---|---|---|
3.80749961374406e-06 | 0.00241014725549999 | 5 | 137 | Natural killer cell mediated cytotoxicity (KEGG):04650 |
0.000260799159217442 | 0.0323074216336034 | 3 | 72 | Viral myocarditis (KEGG):05416 |
0.000306231484678705 | 0.0323074216336034 | 4 | 188 | Focal Adhesion (Wikipathways):WP306 |
8.11025802005085e-05 | 0.025668966633461 | 4 | 133 | T Cell Receptor Signaling Pathway (Wikipathways):WP69 |
0.000410686867918709 | 0.0371378267703633 | 3 | 84 | DNA damage response (only ATM dependent) (Wikipathways):WP710 |
0.000232672777387803 | 0.0323074216336034 | 6 | 511 | Signaling in Immune system (Reactome):REACT_6900 |
0.00013028542957546 | 0.027490225640422 | 3 | 57 | IL-7 up reg. targets (Netpath):NetPath_19 |
0.000593645898709241 | 0.0469722317353687 | 2 | 21 | {HRAS,27} (Static Module):NA |
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0006952 | defense response | 3.15920037879371e-06 |
GO:0007165 | signal transduction | 3.15920037879371e-06 |
GO:0006968 | cellular defense response | 3.15920037879371e-06 |
GO:0007154 | cell communication | 1.80819303646231e-05 |
GO:0019835 | cytolysis | 7.27155456952761e-05 |
GO:0001906 | cell killing | 7.35227439784253e-05 |
GO:0007166 | cell surface receptor linked signal transduction | 0.000748162774117999 |
GO:0001912 | positive regulation of leukocyte mediated cytotoxicity | 0.00100087214500488 |
GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity | 0.00100087214500488 |
GO:0042269 | regulation of natural killer cell mediated cytotoxicity | 0.00126018343181031 |
GO:0004871 | signal transducer activity | 0.00138870150259774 |
GO:0060089 | molecular transducer activity | 0.00138870150259774 |
GO:0005529 | sugar binding | 0.00168697079771395 |
GO:0031341 | regulation of cell killing | 0.00179634483162779 |
GO:0001910 | regulation of leukocyte mediated cytotoxicity | 0.00179634483162779 |
GO:0002228 | natural killer cell mediated immunity | 0.00193582871108738 |
GO:0042267 | natural killer cell mediated cytotoxicity | 0.00193582871108738 |
GO:0001909 | leukocyte mediated cytotoxicity | 0.00301839651130556 |
GO:0030246 | carbohydrate binding | 0.00517328494193105 |
GO:0032502 | developmental process | 0.00592166323900008 |
GO:0042287 | MHC protein binding | 0.00714615676614147 |
GO:0004872 | receptor activity | 0.0111125372061156 |
GO:0002429 | immune response-activating cell surface receptor signaling pathway | 0.0111616425003951 |
GO:0002768 | immune response-regulating cell surface receptor signaling pathway | 0.0112420450095393 |
GO:0002757 | immune response-activating signal transduction | 0.0112420450095393 |
GO:0032393 | MHC class I receptor activity | 0.0112420450095393 |
GO:0002764 | immune response-regulating signal transduction | 0.0115157528199679 |
GO:0046649 | lymphocyte activation | 0.0126404207531485 |
GO:0005886 | plasma membrane | 0.0136008522554332 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 0.0152332451505962 |
GO:0050528 | acyloxyacyl hydrolase activity | 0.0160270083928854 |
GO:0002223 | stimulatory C-type lectin receptor signaling pathway | 0.0160270083928854 |
GO:0032394 | MHC class Ib receptor activity | 0.0160270083928854 |
GO:0045321 | leukocyte activation | 0.0160270083928854 |
GO:0009897 | external side of plasma membrane | 0.0203583098090236 |
GO:0001775 | cell activation | 0.0231316833403306 |
GO:0004888 | transmembrane receptor activity | 0.0231316833403306 |
GO:0019992 | diacylglycerol binding | 0.0248220893604138 |
GO:0002220 | innate immune response activating cell surface receptor signaling pathway | 0.0248220893604138 |
GO:0001785 | prostaglandin J receptor activity | 0.0248220893604138 |
GO:0004956 | prostaglandin D receptor activity | 0.0248220893604138 |
GO:0002253 | activation of immune response | 0.0248220893604138 |
GO:0007264 | small GTPase mediated signal transduction | 0.0248220893604138 |
GO:0002449 | lymphocyte mediated immunity | 0.0248220893604138 |
GO:0006927 | transformed cell apoptosis | 0.0248220893604138 |
GO:0052185 | modification of structure of other organism during symbiotic interaction | 0.0248220893604138 |
GO:0051818 | disruption of cells of other organism during symbiotic interaction | 0.0248220893604138 |
GO:0051883 | killing of cells in other organism during symbiotic interaction | 0.0248220893604138 |
GO:0044004 | disruption by symbiont of host cells | 0.0248220893604138 |
GO:0051817 | modification of morphology or physiology of other organism during symbiotic interaction | 0.0248220893604138 |
GO:0051715 | cytolysis of cells of another organism | 0.0248220893604138 |
GO:0052332 | modification by organism of cell membrane in other organism during symbiotic interaction | 0.0248220893604138 |
GO:0052111 | modification by symbiont of host structure | 0.0248220893604138 |
GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity | 0.0248220893604138 |
GO:0052331 | hemolysis by organism of red blood cells in other organism during symbiotic interaction | 0.0248220893604138 |
GO:0019836 | hemolysis by symbiont of host red blood cells | 0.0248220893604138 |
GO:0052025 | modification by symbiont of host cell membrane | 0.0248220893604138 |
GO:0051801 | cytolysis of cells in other organism during symbiotic interaction | 0.0248220893604138 |
GO:0045085 | negative regulation of interleukin-2 biosynthetic process | 0.0248220893604138 |
GO:0001907 | killing by symbiont of host cells | 0.0248220893604138 |
GO:0052043 | modification by symbiont of host cellular component | 0.0248220893604138 |
GO:0031640 | killing of cells of another organism | 0.0248220893604138 |
GO:0001897 | cytolysis by symbiont of host cells | 0.0248220893604138 |
GO:0044003 | modification by symbiont of host morphology or physiology | 0.0248220893604138 |
GO:0052188 | modification of cellular component in other organism during symbiotic interaction | 0.0248220893604138 |
GO:0002443 | leukocyte mediated immunity | 0.0252276812096993 |
GO:0016265 | death | 0.0252276812096993 |
GO:0008219 | cell death | 0.0252276812096993 |
GO:0051239 | regulation of multicellular organismal process | 0.0268161173699717 |
GO:0031226 | intrinsic to plasma membrane | 0.0272631429682332 |
GO:0050778 | positive regulation of immune response | 0.0282900651600007 |
GO:0002684 | positive regulation of immune system process | 0.0282900651600007 |
GO:0006954 | inflammatory response | 0.0282900651600007 |
GO:0042221 | response to chemical stimulus | 0.0282900651600007 |
GO:0042289 | MHC class II protein binding | 0.0282900651600007 |
GO:0006926 | virus-infected cell apoptosis | 0.0282900651600007 |
GO:0007610 | behavior | 0.0283669156309477 |
GO:0004713 | protein-tyrosine kinase activity | 0.0315735187959461 |
GO:0005085 | guanyl-nucleotide exchange factor activity | 0.0316006328384633 |
GO:0042110 | T cell activation | 0.0316006328384633 |
GO:0050776 | regulation of immune response | 0.0316006328384633 |
GO:0032729 | positive regulation of interferon-gamma production | 0.0316006328384633 |
GO:0002218 | activation of innate immune response | 0.0316006328384633 |
GO:0002758 | innate immune response-activating signal transduction | 0.0316006328384633 |
GO:0030238 | male sex determination | 0.0316006328384633 |
GO:0009605 | response to external stimulus | 0.0319202106836106 |
GO:0002682 | regulation of immune system process | 0.0319202106836106 |
GO:0007242 | intracellular signaling cascade | 0.0334959429843757 |
GO:0031224 | intrinsic to membrane | 0.0334959429843757 |
GO:0051240 | positive regulation of multicellular organismal process | 0.0334959429843757 |
GO:0051704 | multi-organism process | 0.0334959429843757 |
GO:0004252 | serine-type endopeptidase activity | 0.0334959429843757 |
GO:0004465 | lipoprotein lipase activity | 0.0342708827623643 |
GO:0032649 | regulation of interferon-gamma production | 0.0342708827623643 |
GO:0048518 | positive regulation of biological process | 0.0347828901366737 |
GO:0002252 | immune effector process | 0.0347828901366737 |
GO:0050789 | regulation of biological process | 0.0349508232004269 |
GO:0001816 | cytokine production | 0.0358879717932517 |
GO:0045087 | innate immune response | 0.0361337974734535 |
GO:0043550 | regulation of lipid kinase activity | 0.0375627317055293 |
GO:0042993 | positive regulation of transcription factor import into nucleus | 0.0400389946836785 |
GO:0045429 | positive regulation of nitric oxide biosynthetic process | 0.0400389946836785 |
GO:0006491 | N-glycan processing | 0.0400389946836785 |
GO:0042307 | positive regulation of protein import into nucleus | 0.0400389946836785 |
GO:0004691 | cAMP-dependent protein kinase activity | 0.0400389946836785 |
GO:0045471 | response to ethanol | 0.0400389946836785 |
GO:0008236 | serine-type peptidase activity | 0.0400389946836785 |
GO:0017171 | serine hydrolase activity | 0.0400389946836785 |
GO:0005515 | protein binding | 0.0401205382710156 |
GO:0031348 | negative regulation of defense response | 0.0434603528758918 |
GO:0050728 | negative regulation of inflammatory response | 0.0434603528758918 |
GO:0006955 | immune response | 0.0461820368963266 |
GO:0046824 | positive regulation of nucleocytoplasmic transport | 0.0461820368963266 |
GO:0045428 | regulation of nitric oxide biosynthetic process | 0.0461820368963266 |
GO:0004960 | thromboxane receptor activity | 0.0461820368963266 |
GO:0045089 | positive regulation of innate immune response | 0.0461820368963266 |
GO:0042330 | taxis | 0.0474244108887489 |
GO:0006935 | chemotaxis | 0.0474244108887489 |
GO:0050868 | negative regulation of T cell activation | 0.0479396864995311 |
GO:0045088 | regulation of innate immune response | 0.0479396864995311 |
GO:0051222 | positive regulation of protein transport | 0.0479396864995311 |
GO:0009986 | cell surface | 0.0479396864995311 |
GO:0009611 | response to wounding | 0.0479396864995311 |
GO:0009966 | regulation of signal transduction | 0.0491226070247582 |
GO:0005089 | Rho guanyl-nucleotide exchange factor activity | 0.0491226070247582 |
GO:0007265 | Ras protein signal transduction | 0.0491226070247582 |
GO:0048468 | cell development | 0.0491226070247582 |
GO:0004690 | cyclic nucleotide-dependent protein kinase activity | 0.0497779998182119 |
GO:0050832 | defense response to fungus | 0.0497779998182119 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
blood | 7.78e-28 | 15 |
haemolymphatic fluid | 7.78e-28 | 15 |
organism substance | 7.78e-28 | 15 |
hemopoietic organ | 3.31e-14 | 7 |
immune organ | 3.31e-14 | 7 |
thymus | 1.18e-11 | 4 |
hemolymphoid system gland | 1.18e-11 | 4 |
thymic region | 1.18e-11 | 4 |
pharyngeal gland | 1.18e-11 | 4 |
thymus primordium | 1.18e-11 | 4 |
hemolymphoid system | 9.59e-11 | 108 |
hematopoietic system | 3.59e-10 | 98 |
blood island | 3.59e-10 | 98 |
adult organism | 1.87e-08 | 114 |
pharyngeal epithelium | 8.71e-08 | 6 |
chordate pharynx | 6.16e-07 | 10 |
pharyngeal region of foregut | 6.16e-07 | 10 |
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 3.46676e-14 |
MA0004.1 | 0.0254158 |
MA0006.1 | 0.00117558 |
MA0007.1 | 0.191475 |
MA0009.1 | 2.88655 |
MA0014.1 | 2.72804e-08 |
MA0017.1 | 0.299887 |
MA0019.1 | 0.27611 |
MA0024.1 | 0.0423428 |
MA0025.1 | 0.187787 |
MA0027.1 | 1.16868 |
MA0028.1 | 0.010923 |
MA0029.1 | 1.80036 |
MA0030.1 | 0.995909 |
MA0031.1 | 0.503746 |
MA0038.1 | 0.0531156 |
MA0040.1 | 0.755779 |
MA0041.1 | 0.193648 |
MA0042.1 | 0.0420245 |
MA0043.1 | 0.091292 |
MA0046.1 | 0.412673 |
MA0048.1 | 0.0200015 |
MA0050.1 | 0.72445 |
MA0051.1 | 0.0503462 |
MA0052.1 | 0.0108423 |
MA0055.1 | 0.00271943 |
MA0056.1 | 0 |
MA0057.1 | 0.247102 |
MA0058.1 | 0.00315927 |
MA0059.1 | 0.217383 |
MA0060.1 | 0.000114417 |
MA0061.1 | 0.0407894 |
MA0063.1 | 0 |
MA0066.1 | 0.599726 |
MA0067.1 | 0.119562 |
MA0068.1 | 0.0605026 |
MA0069.1 | 0.665293 |
MA0070.1 | 1.30915 |
MA0071.1 | 0.12186 |
MA0072.1 | 0.0745112 |
MA0073.1 | 1.78667e-05 |
MA0074.1 | 0.412621 |
MA0076.1 | 0.0799919 |
MA0077.1 | 0.36107 |
MA0078.1 | 0.0274505 |
MA0081.1 | 1.89278 |
MA0083.1 | 0.0219181 |
MA0084.1 | 1.18478 |
MA0087.1 | 1.27711 |
MA0088.1 | 0.00310864 |
MA0089.1 | 0 |
MA0090.1 | 0.032781 |
MA0091.1 | 0.0977059 |
MA0092.1 | 0.0556276 |
MA0093.1 | 0.0154003 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.122456 |
MA0101.1 | 0.0168031 |
MA0103.1 | 0.138684 |
MA0105.1 | 0.00234597 |
MA0106.1 | 0.407411 |
MA0107.1 | 0.0123686 |
MA0108.2 | 0.167846 |
MA0109.1 | 0 |
MA0111.1 | 1.00951 |
MA0113.1 | 0.0470813 |
MA0114.1 | 0.20598 |
MA0115.1 | 0.0867211 |
MA0116.1 | 0.13226 |
MA0117.1 | 0.114427 |
MA0119.1 | 0.0234897 |
MA0122.1 | 0.311735 |
MA0124.1 | 3.11786 |
MA0125.1 | 0.390068 |
MA0130.1 | 0 |
MA0131.1 | 0.0841822 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 1.57886 |
MA0136.1 | 3.03895 |
MA0139.1 | 0.00316067 |
MA0140.1 | 0.992468 |
MA0141.1 | 0.29607 |
MA0142.1 | 0.418679 |
MA0143.1 | 0.30583 |
MA0144.1 | 1.19114 |
MA0145.1 | 0.0969997 |
MA0146.1 | 1.75173e-05 |
MA0147.1 | 0.0269476 |
MA0148.1 | 0.765548 |
MA0149.1 | 0.397422 |
MA0062.2 | 0.514518 |
MA0035.2 | 3.15627 |
MA0039.2 | 4.15863e-05 |
MA0138.2 | 0.256634 |
MA0002.2 | 5.41131 |
MA0137.2 | 0.319792 |
MA0104.2 | 0.00595026 |
MA0047.2 | 0.240964 |
MA0112.2 | 0.0871079 |
MA0065.2 | 0.249531 |
MA0150.1 | 0.145108 |
MA0151.1 | 0 |
MA0152.1 | 0.456769 |
MA0153.1 | 0.651251 |
MA0154.1 | 0.0120493 |
MA0155.1 | 0.00175591 |
MA0156.1 | 5.69898 |
MA0157.1 | 0.351628 |
MA0158.1 | 0 |
MA0159.1 | 0.19786 |
MA0160.1 | 0.0913128 |
MA0161.1 | 0 |
MA0162.1 | 2.13454e-13 |
MA0163.1 | 0.00486329 |
MA0164.1 | 0.50036 |
MA0080.2 | 5.05439 |
MA0018.2 | 0.0393838 |
MA0099.2 | 0.0333663 |
MA0079.2 | 0 |
MA0102.2 | 1.27487 |
MA0258.1 | 0.165327 |
MA0259.1 | 0.00042384 |
MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data