Coexpression cluster:C129

Full id: C129_liver_Hepatocyte_colon_duodenum_temporal_testicular_small

Phase1 CAGE Peaks

Hg19::chr10:109856810..109856815,+	p@chr10:109856810..109856815 +
Hg19::chr10:118342385..118342386,-	p@chr10:118342385..118342386 -
Hg19::chr10:22046872..22046874,+	p@chr10:22046872..22046874 +
Hg19::chr10:54531372..54531384,-	p1@MBL2
Hg19::chr10:54531406..54531426,-	p2@MBL2
Hg19::chr10:74653492..74653504,+	p4@OIT3
Hg19::chr10:74653506..74653521,+	p1@OIT3
Hg19::chr10:74653522..74653535,+	p2@OIT3
Hg19::chr10:74653538..74653547,+	p5@OIT3
Hg19::chr10:91403625..91403649,-	p4@PANK1
Hg19::chr10:95351747..95351759,+	p2@CU676593
Hg19::chr10:95351763..95351773,+	p3@CU676593
Hg19::chr11:116700614..116700631,+	p1@APOC3
Hg19::chr11:116701496..116701523,+	p@chr11:116701496..116701523 +
Hg19::chr11:116701530..116701546,+	p@chr11:116701530..116701546 +
Hg19::chr11:116703597..116703615,+	p5@APOC3
Hg19::chr11:116703645..116703664,-	p@chr11:116703645..116703664 -
Hg19::chr11:116706805..116706829,-	p@chr11:116706805..116706829 -
Hg19::chr11:116706945..116706953,-	p@chr11:116706945..116706953 -
Hg19::chr11:116706961..116706976,-	p@chr11:116706961..116706976 -
Hg19::chr11:116706971..116706988,+	p1@DQ656025
Hg19::chr11:116707091..116707117,-	p@chr11:116707091..116707117 -
Hg19::chr11:116708330..116708347,-	p1@APOA1
Hg19::chr11:2018018..2018021,-	p2@MIR675
Hg19::chr11:2162543..2162562,-	p61@IGF2
Hg19::chr11:63137251..63137267,+	p1@SLC22A9
Hg19::chr12:104866693..104866694,+	p@chr12:104866693..104866694 +
Hg19::chr12:4488872..4488879,-	p1@FGF23
Hg19::chr12:56881993..56882009,-	p5@GLS2
Hg19::chr12:6927703..6927726,+	p@chr12:6927703..6927726 +
Hg19::chr12:6927729..6927757,+	p@chr12:6927729..6927757 +
Hg19::chr12:96389702..96389722,-	p1@HAL
Hg19::chr13:41363739..41363753,+	p2@SLC25A15
Hg19::chr13:41455066..41455070,-	p@chr13:41455066..41455070 -
Hg19::chr14:94844000..94844007,-	p@chr14:94844000..94844007 -
Hg19::chr14:94844867..94844883,+	p2@CU680153
Hg19::chr14:94844932..94844943,-	p30@SERPINA1
Hg19::chr14:94845856..94845857,-	p43@SERPINA1
Hg19::chr14:94849340..94849371,+	p@chr14:94849340..94849371 +
Hg19::chr14:94849372..94849459,+	p@chr14:94849372..94849459 +
Hg19::chr15:102028948..102028954,+	p@chr15:102028948..102028954 +
Hg19::chr15:41548892..41548919,+	p9@CHP
Hg19::chr15:51610687..51610695,-	p4@CYP19A1
Hg19::chr15:58724170..58724183,+	p3@LIPC
Hg19::chr15:58724184..58724197,+	p2@LIPC
Hg19::chr15:81611633..81611637,-	p@chr15:81611633..81611637 -
Hg19::chr16:51593720..51593721,-	p@chr16:51593720..51593721 -
Hg19::chr16:56666563..56666580,+	p2@MT1M
Hg19::chr16:56677565..56677579,+	p2@MT1DP
Hg19::chr16:56685796..56685801,+	p1@MT1B
Hg19::chr16:56691887..56691909,+	p1@MT1F
Hg19::chr16:56700715..56700727,-	p@chr16:56700715..56700727 -
Hg19::chr16:56700737..56700752,+	p@chr16:56700737..56700752 +
Hg19::chr16:56701968..56701983,-	p1@MT1G
Hg19::chr16:56703761..56703789,+	p2@MT1H
Hg19::chr16:76566169..76566180,-	p@chr16:76566169..76566180 -
Hg19::chr17:36860807..36860829,-	p@chr17:36860807..36860829 -
Hg19::chr17:4692230..4692265,+	p1@GLTPD2
Hg19::chr17:4692269..4692278,+	p6@GLTPD2
Hg19::chr17:4692335..4692344,+	p3@GLTPD2
Hg19::chr17:4692350..4692364,+	p2@GLTPD2
Hg19::chr17:7018100..7018111,-	p4@ASGR2
Hg19::chr17:7960200..7960204,+	p1@uc002gjx.1
Hg19::chr18:56067319..56067325,-	p@chr18:56067319..56067325 -
Hg19::chr19:11350278..11350302,+	p1@C19orf80
Hg19::chr19:45451955..45451977,+	p5@APOC2
Hg19::chr19:6712541..6712560,+	p@chr19:6712541..6712560 +
Hg19::chr19:6718256..6718299,+	p@chr19:6718256..6718299 +
Hg19::chr19:6719228..6719237,+	p@chr19:6719228..6719237 +
Hg19::chr19:6719256..6719265,-	p@chr19:6719256..6719265 -
Hg19::chr19:6719365..6719380,+	p@chr19:6719365..6719380 +
Hg19::chr1:120311553..120311555,-	p2@HMGCS2
Hg19::chr1:161192171..161192185,-	p@chr1:161192171..161192185 -
Hg19::chr1:161192276..161192297,-	p@chr1:161192276..161192297 -
Hg19::chr1:16410268..16410271,-	p@chr1:16410268..16410271 -
Hg19::chr1:207262540..207262551,+	p13@C4BPB
Hg19::chr1:207262571..207262574,+	p19@C4BPB
Hg19::chr1:230839071..230839081,-	p@chr1:230839071..230839081 -
Hg19::chr1:230840033..230840046,+	p@chr1:230840033..230840046 +
Hg19::chr1:230841888..230841906,-	p@chr1:230841888..230841906 -
Hg19::chr1:230841927..230841948,-	p@chr1:230841927..230841948 -
Hg19::chr1:230845912..230845927,-	p@chr1:230845912..230845927 -
Hg19::chr1:230846000..230846009,-	p@chr1:230846000..230846009 -
Hg19::chr1:230846364..230846384,+	p1@M26228
Hg19::chr1:230846397..230846417,-	p2@AGT
Hg19::chr1:230849858..230849875,-	p1@AGT
Hg19::chr1:48121226..48121227,+	p@chr1:48121226..48121227 +
Hg19::chr1:80339337..80339339,+	p@chr1:80339337..80339339 +
Hg19::chr20:36956110..36956113,-	p@chr20:36956110..36956113 -
Hg19::chr20:4163964..4164001,+	p@chr20:4163964..4164001 +
Hg19::chr22:26921050..26921055,+	p@chr22:26921050..26921055 +
Hg19::chr22:30953574..30953584,-	p13@GAL3ST1
Hg19::chr22:30953587..30953595,-	p15@GAL3ST1
Hg19::chr22:37505474..37505478,-	p3@TMPRSS6
Hg19::chr2:164347637..164347639,-	p@chr2:164347637..164347639 -
Hg19::chr2:211542816..211542823,+	p@chr2:211542816..211542823 +
Hg19::chr2:21234737..21234744,-	p116@APOB
Hg19::chr2:21256354..21256359,-	p@chr2:21256354..21256359 -
Hg19::chr2:21257701..21257711,+	p@chr2:21257701..21257711 +
Hg19::chr2:21260016..21260042,+	p@chr2:21260016..21260042 +
Hg19::chr2:21265277..21265305,+	p@chr2:21265277..21265305 +
Hg19::chr2:234959355..234959371,+	p2@SPP2
Hg19::chr2:234959376..234959402,+	p1@SPP2
Hg19::chr2:241808165..241808178,+	p2@AGXT
Hg19::chr2:97216094..97216105,+	p@chr2:97216094..97216105 +
Hg19::chr3:133473408..133473419,+	p10@TF
Hg19::chr3:142682480..142682497,-	p3@PAQR9
Hg19::chr3:186330841..186330863,+	p1@AHSG
Hg19::chr3:186333534..186333545,+	p@chr3:186333534..186333545 +
Hg19::chr3:186334990..186335031,+	p@chr3:186334990..186335031 +
Hg19::chr3:186335044..186335062,+	p@chr3:186335044..186335062 +
Hg19::chr3:186336312..186336319,+	p@chr3:186336312..186336319 +
Hg19::chr3:186338441..186338458,+	p@chr3:186338441..186338458 +
Hg19::chr3:186338947..186338958,+	p@chr3:186338947..186338958 +
Hg19::chr3:186338971..186338979,+	p@chr3:186338971..186338979 +
Hg19::chr3:32280051..32280087,-	p1@BC035064
Hg19::chr3:52821910..52821922,+	p6@ITIH1
Hg19::chr4:74274493..74274496,+	p45@ALB
Hg19::chr4:74283355..74283358,-	p@chr4:74283355..74283358 -
Hg19::chr4:74319533..74319551,+	p@chr4:74319533..74319551 +
Hg19::chr5:126215130..126215131,+	p@chr5:126215130..126215131 +
Hg19::chr5:132209353..132209366,+	p1@LEAP2
Hg19::chr6:43027721..43027733,+	p5@KLC4
Hg19::chr6:5085572..5085576,+	p2@PPP1R3G
Hg19::chr7:100238869..100238883,-	p@chr7:100238869..100238883 -
Hg19::chr7:45928132..45928134,+	p11@IGFBP1
Hg19::chr7:99332815..99332820,-	p1@CYP3A7 p2@CYP3A5
Hg19::chr8:28244374..28244382,-	p26@ZNF395
Hg19::chr9:104145795..104145806,-	p4@BAAT
Hg19::chr9:107666048..107666061,-	p7@ABCA1
Hg19::chr9:116823375..116823380,-	p7@AMBP
Hg19::chr9:4839762..4839779,+	p6@RCL1
Hg19::chr9:4839818..4839828,+	p8@RCL1
Hg19::chrX:105251903..105251912,-	p@chrX:105251903..105251912 -
Hg19::chrX:108976521..108976545,-	p3@ACSL4
Hg19::chrX:132670143..132670152,-	p@chrX:132670143..132670152 -
Hg19::chrX:132670211..132670224,-	p@chrX:132670211..132670224 -
Hg19::chrX:153769409..153769421,+	p15@IKBKG
Hg19::chrX:49832232..49832267,+	p5@CLCN5

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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p.value	FDR	nGenes	nPathway	Name
0.00144205629233543	0.0480432438446489	2	32	Alanine, aspartate and glutamate metabolism (KEGG):00250
0.000743006892537071	0.0276660801750568	2	23	Nitrogen metabolism (KEGG):00910
2.33960129959674e-05	0.00148096762264474	10	1138	Metabolic pathways (KEGG):01100
7.42008564011457e-06	0.000587114276274066	4	71	PPAR signaling pathway (KEGG):03320
0.000350668237711625	0.0158552138908185	3	78	Peroxisome (KEGG):04146
0.00024419772182117	0.011890550608677	3	69	Complement and coagulation cascades (KEGG):04610
7.27844308158643e-05	0.0041884131551311	3	46	Fat digestion and absorption (KEGG):04975
0.000809646467080959	0.0284725674256804	2	24	Vitamin digestion and absorption (KEGG):04977
3.58995175067169e-10	7.57479819391727e-08	6	51	Mineral absorption (KEGG):04978
4.03691869703112e-06	0.00041561279877618	4	61	Selenium Pathway (Wikipathways):WP15
2.11867675407872e-06	0.000268224477066366	4	52	Vitamin B12 Metabolism (Wikipathways):WP1533
4.5960341096892e-06	0.00041561279877618	4	63	Folate Metabolism (Wikipathways):WP176
9.7484418554213e-12	3.08538184724084e-09	6	29	Statin Pathway (Wikipathways):WP430
0.000158531570085429	0.00836254032200637	6	466	Hemostasis (Reactome):REACT_604
7.95131208698848e-14	5.03318055106371e-11	12	289	Metabolism of lipids and lipoproteins (Reactome):REACT_22258
0.000380315550878904	0.0160493162470897	4	195	Metabolism of amino acids and derivatives (Reactome):REACT_13
8.71044580910769e-06	0.000612634688573907	5	159	EGFR1 up reg. targets (Netpath):NetPath_4
1.85032686852687e-09	2.92814226944378e-07	5	30	{SDC1,30} (Static Module):NA
0.000483198215429275	0.0191165293979207	3	87	{SP1,88} (Static Module):NA

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005615	extracellular space	1.48086432370248e-10
GO:0044421	extracellular region part	6.57448167385691e-08
GO:0046870	cadmium ion binding	1.07053834821666e-07
GO:0032501	multicellular organismal process	1.07098905689507e-07
GO:0006629	lipid metabolic process	5.39357397914303e-07
GO:0005319	lipid transporter activity	5.39357397914303e-07
GO:0044255	cellular lipid metabolic process	5.93014759482007e-07
GO:0015918	sterol transport	8.58942756579416e-07
GO:0030301	cholesterol transport	8.58942756579416e-07
GO:0006869	lipid transport	2.52091414113614e-06
GO:0065008	regulation of biological quality	3.440761370017e-06
GO:0002526	acute inflammatory response	5.52163142747491e-06
GO:0051239	regulation of multicellular organismal process	6.07008552608326e-06
GO:0042627	chylomicron	8.0558945854026e-06
GO:0006810	transport	2.80207081469866e-05
GO:0005507	copper ion binding	2.88256114622693e-05
GO:0008202	steroid metabolic process	2.88256114622693e-05
GO:0051234	establishment of localization	4.20686384807624e-05
GO:0004866	endopeptidase inhibitor activity	5.25691872096465e-05
GO:0030414	protease inhibitor activity	6.83242618215475e-05
GO:0006641	triacylglycerol metabolic process	7.69547300248815e-05
GO:0009605	response to external stimulus	7.69547300248815e-05
GO:0030139	endocytic vesicle	0.000133068156671684
GO:0008203	cholesterol metabolic process	0.00013524283622399
GO:0006638	neutral lipid metabolic process	0.00013524283622399
GO:0006639	acylglycerol metabolic process	0.00013524283622399
GO:0046486	glycerolipid metabolic process	0.000148697483236104
GO:0006662	glycerol ether metabolic process	0.000162087116637339
GO:0051179	localization	0.000162087116637339
GO:0016125	sterol metabolic process	0.000238208181255638
GO:0050776	regulation of immune response	0.000271650017635703
GO:0019752	carboxylic acid metabolic process	0.000271650017635703
GO:0002682	regulation of immune system process	0.000271650017635703
GO:0006082	organic acid metabolic process	0.000271650017635703
GO:0006953	acute-phase response	0.000278980367605687
GO:0004857	enzyme inhibitor activity	0.000396218796457818
GO:0009611	response to wounding	0.000507707147740188
GO:0009308	amine metabolic process	0.000507707147740188
GO:0000267	cell fraction	0.000570676404315978
GO:0033344	cholesterol efflux	0.00058383456311079
GO:0006807	nitrogen compound metabolic process	0.000707087960943878
GO:0032787	monocarboxylic acid metabolic process	0.000889754724505307
GO:0006954	inflammatory response	0.000928048924478177
GO:0005737	cytoplasm	0.00102394198824895
GO:0044444	cytoplasmic part	0.0011977275275191
GO:0019825	oxygen binding	0.00120271997368007
GO:0008015	blood circulation	0.00120271997368007
GO:0003013	circulatory system process	0.00120271997368007
GO:0005792	microsome	0.00123633628213574
GO:0004867	serine-type endopeptidase inhibitor activity	0.00139492551803167
GO:0042598	vesicular fraction	0.00139934583542896
GO:0030500	regulation of bone mineralization	0.00163961905541608
GO:0002253	activation of immune response	0.00204588633702832
GO:0006631	fatty acid metabolic process	0.00208076718368457
GO:0006952	defense response	0.00208076718368457
GO:0001501	skeletal development	0.00288535090839581
GO:0006950	response to stress	0.00318817735025831
GO:0050778	positive regulation of immune response	0.00318817735025831
GO:0002684	positive regulation of immune system process	0.00324434981061394
GO:0030278	regulation of ossification	0.00428912329622161
GO:0046849	bone remodeling	0.00428912329622161
GO:0005624	membrane fraction	0.00428912329622161
GO:0030282	bone mineralization	0.00452216305197419
GO:0007596	blood coagulation	0.00452216305197419
GO:0005777	peroxisome	0.00452216305197419
GO:0042579	microbody	0.00452216305197419
GO:0050817	coagulation	0.00472121610869589
GO:0051240	positive regulation of multicellular organismal process	0.00491967566122464
GO:0048771	tissue remodeling	0.00491967566122464
GO:0007599	hemostasis	0.00491967566122464
GO:0006520	amino acid metabolic process	0.00543490017068413
GO:0046850	regulation of bone remodeling	0.00587610010638861
GO:0022892	substrate-specific transporter activity	0.00620908591586319
GO:0051241	negative regulation of multicellular organismal process	0.00620908591586319
GO:0050381	unspecific monooxygenase activity	0.00654385201519291
GO:0042552	myelination	0.00654385201519291
GO:0050878	regulation of body fluid levels	0.00740307464757534
GO:0006958	complement activation, classical pathway	0.00740307464757534
GO:0042060	wound healing	0.00829211968876683
GO:0002455	humoral immune response mediated by circulating immunoglobulin	0.00829211968876683
GO:0006519	amino acid and derivative metabolic process	0.00898918200096567
GO:0008366	axon ensheathment	0.00898918200096567
GO:0008286	insulin receptor signaling pathway	0.00898918200096567
GO:0007272	ensheathment of neurons	0.00898918200096567
GO:0016042	lipid catabolic process	0.00943506417049335
GO:0051704	multi-organism process	0.00943506417049335
GO:0008610	lipid biosynthetic process	0.00943506417049335
GO:0008289	lipid binding	0.00943506417049335
GO:0016247	channel regulator activity	0.00943506417049335
GO:0048731	system development	0.00943506417049335
GO:0006956	complement activation	0.00943506417049335
GO:0002541	activation of plasma proteins during acute inflammatory response	0.00943506417049335
GO:0048856	anatomical structure development	0.00943506417049335
GO:0001508	regulation of action potential	0.00943506417049335
GO:0002018	renin-angiotensin regulation of aldosterone production	0.00943506417049335
GO:0030568	plasmin inhibitor activity	0.00943506417049335
GO:0015682	ferric iron transport	0.00943506417049335
GO:0031643	positive regulation of myelination	0.00943506417049335
GO:0048143	astrocyte activation	0.00943506417049335
GO:0031701	angiotensin receptor binding	0.00943506417049335
GO:0002019	angiotensin mediated regulation of renal output	0.00943506417049335
GO:0004760	serine-pyruvate transaminase activity	0.00943506417049335
GO:0031703	type 2 angiotensin receptor binding	0.00943506417049335
GO:0043395	heparan sulfate proteoglycan binding	0.00943506417049335
GO:0019375	galactolipid biosynthetic process	0.00943506417049335
GO:0004397	histidine ammonia-lyase activity	0.00943506417049335
GO:0046724	oxalic acid secretion	0.00943506417049335
GO:0060155	platelet dense granule organization and biogenesis	0.00943506417049335
GO:0043394	proteoglycan binding	0.00943506417049335
GO:0042866	pyruvate biosynthetic process	0.00943506417049335
GO:0006682	galactosylceramide biosynthetic process	0.00943506417049335
GO:0046622	positive regulation of organ growth	0.00943506417049335
GO:0019265	glycine biosynthetic process, by transamination of glyoxylate	0.00943506417049335
GO:0051657	maintenance of organelle localization	0.00943506417049335
GO:0006642	triacylglycerol mobilization	0.00943506417049335
GO:0045723	positive regulation of fatty acid biosynthetic process	0.00943506417049335
GO:0046904	calcium oxalate binding	0.00943506417049335
GO:0042756	drinking behavior	0.00943506417049335
GO:0043691	reverse cholesterol transport	0.00943506417049335
GO:0015091	ferric iron transmembrane transporter activity	0.00943506417049335
GO:0001999	renal response to blood flow during renin-angiotensin regulation of systemic arterial blood pressure	0.00943506417049335
GO:0051659	maintenance of mitochondrion localization	0.00943506417049335
GO:0047963	glycine N-choloyltransferase activity	0.00943506417049335
GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure	0.00943506417049335
GO:0031702	type 1 angiotensin receptor binding	0.00943506417049335
GO:0006544	glycine metabolic process	0.0108073824515304
GO:0030198	extracellular matrix organization and biogenesis	0.0121622031698151
GO:0016712	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	0.0121622031698151
GO:0004091	carboxylesterase activity	0.0141346188940538
GO:0016064	immunoglobulin mediated immune response	0.0143731936705695
GO:0019724	B cell mediated immunity	0.0143731936705695
GO:0006487	protein amino acid N-linked glycosylation	0.0143731936705695
GO:0010324	membrane invagination	0.0143731936705695
GO:0006897	endocytosis	0.0143731936705695
GO:0009069	serine family amino acid metabolic process	0.0143731936705695
GO:0040008	regulation of growth	0.0143731936705695
GO:0000066	mitochondrial ornithine transport	0.0143731936705695
GO:0033700	phospholipid efflux	0.0143731936705695
GO:0014821	phasic smooth muscle contraction	0.0143731936705695
GO:0003072	renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence	0.0143731936705695
GO:0004421	hydroxymethylglutaryl-CoA synthase activity	0.0143731936705695
GO:0033363	secretory granule organization and biogenesis	0.0143731936705695
GO:0002034	renin-angiotensin regulation of blood vessel size	0.0143731936705695
GO:0000064	L-ornithine transmembrane transporter activity	0.0143731936705695
GO:0055091	phospholipid homeostasis	0.0143731936705695
GO:0002016	renin-angiotensin regulation of blood volume	0.0143731936705695
GO:0046337	phosphatidylethanolamine metabolic process	0.0143731936705695
GO:0002035	brain renin-angiotensin system	0.0143731936705695
GO:0001867	complement activation, lectin pathway	0.0143731936705695
GO:0008065	establishment of blood-nerve barrier	0.0143731936705695
GO:0030810	positive regulation of nucleotide biosynthetic process	0.0143731936705695
GO:0043072	negative regulation of non-apoptotic programmed cell death	0.0143731936705695
GO:0030816	positive regulation of cAMP metabolic process	0.0143731936705695
GO:0045981	positive regulation of nucleotide metabolic process	0.0143731936705695
GO:0030432	peristalsis	0.0143731936705695
GO:0030801	positive regulation of cyclic nucleotide metabolic process	0.0143731936705695
GO:0001543	ovarian follicle rupture	0.0143731936705695
GO:0030349	syntaxin-13 binding	0.0143731936705695
GO:0042304	regulation of fatty acid biosynthetic process	0.0143731936705695
GO:0030804	positive regulation of cyclic nucleotide biosynthetic process	0.0143731936705695
GO:0019862	IgA binding	0.0143731936705695
GO:0030819	positive regulation of cAMP biosynthetic process	0.0143731936705695
GO:0019855	calcium channel inhibitor activity	0.0143731936705695
GO:0015822	ornithine transport	0.0143731936705695
GO:0048518	positive regulation of biological process	0.015645726955851
GO:0031667	response to nutrient levels	0.0158459236380062
GO:0006066	alcohol metabolic process	0.016009523212049
GO:0010033	response to organic substance	0.0166989084016075
GO:0009991	response to extracellular stimulus	0.0172364109538812
GO:0005625	soluble fraction	0.0172364109538812
GO:0030246	carbohydrate binding	0.0172364109538812
GO:0052185	modification of structure of other organism during symbiotic interaction	0.0172364109538812
GO:0030304	trypsin inhibitor activity	0.0172364109538812
GO:0051883	killing of cells in other organism during symbiotic interaction	0.0172364109538812
GO:0046476	glycosylceramide biosynthetic process	0.0172364109538812
GO:0046329	negative regulation of JNK cascade	0.0172364109538812
GO:0052331	hemolysis by organism of red blood cells in other organism during symbiotic interaction	0.0172364109538812
GO:0001991	regulation of systemic arterial blood pressure by circulatory renin-angiotensin	0.0172364109538812
GO:0003071	renal regulation of systemic arterial blood pressure	0.0172364109538812
GO:0046149	pigment catabolic process	0.0172364109538812
GO:0019836	hemolysis by symbiont of host red blood cells	0.0172364109538812
GO:0051801	cytolysis of cells in other organism during symbiotic interaction	0.0172364109538812
GO:0004873	asialoglycoprotein receptor activity	0.0172364109538812
GO:0001907	killing by symbiont of host cells	0.0172364109538812
GO:0031640	killing of cells of another organism	0.0172364109538812
GO:0001897	cytolysis by symbiont of host cells	0.0172364109538812
GO:0016244	non-apoptotic programmed cell death	0.0172364109538812
GO:0001885	endothelial cell development	0.0172364109538812
GO:0046461	neutral lipid catabolic process	0.0172364109538812
GO:0046487	glyoxylate metabolic process	0.0172364109538812
GO:0051818	disruption of cells of other organism during symbiotic interaction	0.0172364109538812
GO:0008453	alanine-glyoxylate transaminase activity	0.0172364109538812
GO:0044004	disruption by symbiont of host cells	0.0172364109538812
GO:0051817	modification of morphology or physiology of other organism during symbiotic interaction	0.0172364109538812
GO:0051715	cytolysis of cells of another organism	0.0172364109538812
GO:0052332	modification by organism of cell membrane in other organism during symbiotic interaction	0.0172364109538812
GO:0043070	regulation of non-apoptotic programmed cell death	0.0172364109538812
GO:0046889	positive regulation of lipid biosynthetic process	0.0172364109538812
GO:0052111	modification by symbiont of host structure	0.0172364109538812
GO:0042167	heme catabolic process	0.0172364109538812
GO:0045335	phagocytic vesicle	0.0172364109538812
GO:0052025	modification by symbiont of host cell membrane	0.0172364109538812
GO:0052043	modification by symbiont of host cellular component	0.0172364109538812
GO:0044003	modification by symbiont of host morphology or physiology	0.0172364109538812
GO:0052188	modification of cellular component in other organism during symbiotic interaction	0.0172364109538812
GO:0009891	positive regulation of biosynthetic process	0.0172731238559978
GO:0048513	organ development	0.0177257174712722
GO:0032502	developmental process	0.017988280443683
GO:0002449	lymphocyte mediated immunity	0.017988280443683
GO:0003008	system process	0.018221097311605
GO:0006959	humoral immune response	0.0192946558716782
GO:0008201	heparin binding	0.0194307744560461
GO:0002460	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	0.0194307744560461
GO:0009725	response to hormone stimulus	0.0194307744560461
GO:0002250	adaptive immune response	0.0194307744560461
GO:0002443	leukocyte mediated immunity	0.0198656814051785
GO:0009058	biosynthetic process	0.0198656814051785
GO:0006907	pinocytosis	0.0198656814051785
GO:0055062	phosphate ion homeostasis	0.0198656814051785
GO:0031641	regulation of myelination	0.0198656814051785
GO:0032366	intracellular sterol transport	0.0198656814051785
GO:0006545	glycine biosynthetic process	0.0198656814051785
GO:0001733	galactosylceramide sulfotransferase activity	0.0198656814051785
GO:0015643	toxin binding	0.0198656814051785
GO:0046717	acid secretion	0.0198656814051785
GO:0046620	regulation of organ growth	0.0198656814051785
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin	0.0198656814051785
GO:0001542	ovulation from ovarian follicle	0.0198656814051785
GO:0030502	negative regulation of bone mineralization	0.0198656814051785
GO:0014002	astrocyte development	0.0198656814051785
GO:0032365	intracellular lipid transport	0.0198656814051785
GO:0050694	galactose 3-O-sulfotransferase activity	0.0198656814051785
GO:0032367	intracellular cholesterol transport	0.0198656814051785
GO:0030643	cellular phosphate ion homeostasis	0.0198656814051785
GO:0016841	ammonia-lyase activity	0.0198656814051785
GO:0046627	negative regulation of insulin receptor signaling pathway	0.0198656814051785
GO:0046473	phosphatidic acid metabolic process	0.0198656814051785
GO:0007565	female pregnancy	0.0198695617356605
GO:0016053	organic acid biosynthetic process	0.0206597843310698
GO:0046394	carboxylic acid biosynthetic process	0.0206597843310698
GO:0042157	lipoprotein metabolic process	0.0209707789955566
GO:0043062	extracellular structure organization and biogenesis	0.0209707789955566
GO:0065007	biological regulation	0.0224329805746186
GO:0031214	biomineral formation	0.0226204327802265
GO:0001503	ossification	0.0226204327802265
GO:0006694	steroid biosynthetic process	0.0226204327802265
GO:0016044	membrane organization and biogenesis	0.0226204327802265
GO:0051646	mitochondrion localization	0.0226204327802265
GO:0030319	cellular di-, tri-valent inorganic anion homeostasis	0.0226204327802265
GO:0055061	di-, tri-valent inorganic anion homeostasis	0.0226204327802265
GO:0046626	regulation of insulin receptor signaling pathway	0.0226204327802265
GO:0008035	high-density lipoprotein binding	0.0226204327802265
GO:0030728	ovulation	0.0226204327802265
GO:0006787	porphyrin catabolic process	0.0226204327802265
GO:0033015	tetrapyrrole catabolic process	0.0226204327802265
GO:0030817	regulation of cAMP biosynthetic process	0.0226204327802265
GO:0019374	galactolipid metabolic process	0.0226204327802265
GO:0004594	pantothenate kinase activity	0.0226204327802265
GO:0035265	organ growth	0.0226204327802265
GO:0006681	galactosylceramide metabolic process	0.0226204327802265
GO:0020037	heme binding	0.0239199444095962
GO:0046906	tetrapyrrole binding	0.0239199444095962
GO:0048878	chemical homeostasis	0.0256046491335867
GO:0004359	glutaminase activity	0.0256046491335867
GO:0045923	positive regulation of fatty acid metabolic process	0.0256046491335867
GO:0001948	glycoprotein binding	0.0256046491335867
GO:0030802	regulation of cyclic nucleotide biosynthetic process	0.0256046491335867
GO:0030808	regulation of nucleotide biosynthetic process	0.0256046491335867
GO:0055081	anion homeostasis	0.0256046491335867
GO:0005381	iron ion transmembrane transporter activity	0.0256046491335867
GO:0004465	lipoprotein lipase activity	0.0256046491335867
GO:0008385	IkappaB kinase complex	0.0256046491335867
GO:0006349	genetic imprinting	0.0256046491335867
GO:0030814	regulation of cAMP metabolic process	0.0256046491335867
GO:0030002	cellular anion homeostasis	0.0256046491335867
GO:0044429	mitochondrial part	0.0256046491335867
GO:0042221	response to chemical stimulus	0.0258120680052261
GO:0009968	negative regulation of signal transduction	0.0275711386207889
GO:0016192	vesicle-mediated transport	0.0282511015481634
GO:0046470	phosphatidylcholine metabolic process	0.0290563391892623
GO:0003084	positive regulation of systemic arterial blood pressure	0.0290563391892623
GO:0015937	coenzyme A biosynthetic process	0.0290563391892623
GO:0030799	regulation of cyclic nucleotide metabolic process	0.0290563391892623
GO:0005539	glycosaminoglycan binding	0.0299483410283475
GO:0002252	immune effector process	0.0299483410283475
GO:0031967	organelle envelope	0.0300571043717113
GO:0009056	catabolic process	0.0300571043717113
GO:0031975	envelope	0.0302399763811864
GO:0045087	innate immune response	0.0303929885195778
GO:0009409	response to cold	0.0303929885195778
GO:0019627	urea metabolic process	0.0303929885195778
GO:0009267	cellular response to starvation	0.0303929885195778
GO:0048708	astrocyte differentiation	0.0303929885195778
GO:0006677	glycosylceramide metabolic process	0.0303929885195778
GO:0051145	smooth muscle cell differentiation	0.0303929885195778
GO:0000050	urea cycle	0.0303929885195778
GO:0046513	ceramide biosynthetic process	0.0303929885195778
GO:0019217	regulation of fatty acid metabolic process	0.0303929885195778
GO:0050886	endocrine process	0.0303929885195778
GO:0001990	regulation of systemic arterial blood pressure by hormone	0.0303929885195778
GO:0018445	prothoracicotrophic hormone activity	0.0303929885195778
GO:0030279	negative regulation of ossification	0.0303929885195778
GO:0001976	regulation of systemic arterial blood pressure by neurological process	0.0303929885195778
GO:0006658	phosphatidylserine metabolic process	0.0303929885195778
GO:0046890	regulation of lipid biosynthetic process	0.0303929885195778
GO:0043410	positive regulation of MAPKKK cascade	0.0303929885195778
GO:0043603	amide metabolic process	0.0303929885195778
GO:0031646	positive regulation of neurological process	0.0303929885195778
GO:0016290	palmitoyl-CoA hydrolase activity	0.0303929885195778
GO:0030247	polysaccharide binding	0.0304763743155302
GO:0016043	cellular component organization and biogenesis	0.0307704570726559
GO:0030170	pyridoxal phosphate binding	0.0307704570726559
GO:0005739	mitochondrion	0.0307704570726559
GO:0007275	multicellular organismal development	0.031239155641175
GO:0016023	cytoplasmic membrane-bound vesicle	0.0320626442860655
GO:0031988	membrane-bound vesicle	0.0324873069080913
GO:0042730	fibrinolysis	0.0324873069080913
GO:0003014	renal system process	0.0324873069080913
GO:0046520	sphingoid biosynthetic process	0.0324873069080913
GO:0050766	positive regulation of phagocytosis	0.0324873069080913
GO:0016880	acid-ammonia (or amide) ligase activity	0.0324873069080913
GO:0003963	RNA-3'-phosphate cyclase activity	0.0324873069080913
GO:0016211	ammonia ligase activity	0.0324873069080913
GO:0050777	negative regulation of immune response	0.0324873069080913
GO:0015012	heparan sulfate proteoglycan biosynthetic process	0.0324873069080913
GO:0012505	endomembrane system	0.0329919746541193
GO:0005102	receptor binding	0.0340520350007429
GO:0001871	pattern binding	0.0342283290911175
GO:0002683	negative regulation of immune system process	0.0343805568152402
GO:0031669	cellular response to nutrient levels	0.0343805568152402
GO:0050764	regulation of phagocytosis	0.0343805568152402
GO:0006140	regulation of nucleotide metabolic process	0.0343805568152402
GO:0045777	positive regulation of blood pressure	0.0343805568152402
GO:0045834	positive regulation of lipid metabolic process	0.0343805568152402
GO:0001658	ureteric bud branching	0.0343805568152402
GO:0008200	ion channel inhibitor activity	0.0343805568152402
GO:0004467	long-chain-fatty-acid-CoA ligase activity	0.0343805568152402
GO:0050702	interleukin-1 beta secretion	0.0343805568152402
GO:0015645	fatty-acid ligase activity	0.0343805568152402
GO:0030212	hyaluronan metabolic process	0.0343805568152402
GO:0016248	channel inhibitor activity	0.0343805568152402
GO:0007243	protein kinase cascade	0.0365088409130551
GO:0005159	insulin-like growth factor receptor binding	0.0365088409130551
GO:0043524	negative regulation of neuron apoptosis	0.0365088409130551
GO:0005246	calcium channel regulator activity	0.0365088409130551
GO:0009070	serine family amino acid biosynthetic process	0.0365088409130551
GO:0051591	response to cAMP	0.0365088409130551
GO:0046851	negative regulation of bone remodeling	0.0365088409130551
GO:0017127	cholesterol transporter activity	0.0365088409130551
GO:0014070	response to organic cyclic substance	0.0365088409130551
GO:0015936	coenzyme A metabolic process	0.0365088409130551
GO:0045446	endothelial cell differentiation	0.0365088409130551
GO:0050701	interleukin-1 secretion	0.0365088409130551
GO:0046903	secretion	0.0373811331880424
GO:0031090	organelle membrane	0.0384406423736267
GO:0016298	lipase activity	0.0384406423736267
GO:0051384	response to glucocorticoid stimulus	0.0388119603610069
GO:0040018	positive regulation of multicellular organism growth	0.0388119603610069
GO:0003044	regulation of systemic arterial blood pressure mediated by a chemical signal	0.0388119603610069
GO:0030195	negative regulation of blood coagulation	0.0388119603610069
GO:0005537	mannose binding	0.0388119603610069
GO:0030201	heparan sulfate proteoglycan metabolic process	0.0388119603610069
GO:0006548	histidine catabolic process	0.0412214045994903
GO:0021782	glial cell development	0.0412214045994903
GO:0031960	response to corticosteroid stimulus	0.0412214045994903
GO:0015248	sterol transporter activity	0.0412214045994903
GO:0009077	histidine family amino acid catabolic process	0.0412214045994903
GO:0042594	response to starvation	0.0412214045994903
GO:0030193	regulation of blood coagulation	0.0412214045994903
GO:0000165	MAPKKK cascade	0.0415561401497214
GO:0031966	mitochondrial membrane	0.0418541795420645
GO:0016886	ligase activity, forming phosphoric ester bonds	0.0436531434065266
GO:0048659	smooth muscle cell proliferation	0.0436531434065266
GO:0050821	protein stabilization	0.0436531434065266
GO:0031668	cellular response to extracellular stimulus	0.0436531434065266
GO:0042803	protein homodimerization activity	0.0450782411214411
GO:0031410	cytoplasmic vesicle	0.0457640289410509
GO:0008206	bile acid metabolic process	0.0457640289410509
GO:0006625	protein targeting to peroxisome	0.0457640289410509
GO:0009247	glycolipid biosynthetic process	0.0457640289410509
GO:0043408	regulation of MAPKKK cascade	0.0457640289410509
GO:0016840	carbon-nitrogen lyase activity	0.0457640289410509
GO:0050819	negative regulation of coagulation	0.0457640289410509
GO:0001558	regulation of cell growth	0.0462517194614314
GO:0005740	mitochondrial envelope	0.0465941973071202
GO:0031982	vesicle	0.0465941973071202
GO:0001568	blood vessel development	0.0468358300759216
GO:0048519	negative regulation of biological process	0.0470624262182418
GO:0001944	vasculature development	0.0470624262182418
GO:0050818	regulation of coagulation	0.0470624262182418
GO:0019865	immunoglobulin binding	0.0470624262182418
GO:0003073	regulation of systemic arterial blood pressure	0.0470624262182418
GO:0042310	vasoconstriction	0.0470624262182418
GO:0043574	peroxisomal transport	0.0470624262182418
GO:0016050	vesicle organization and biogenesis	0.0470624262182418
GO:0033554	cellular response to stress	0.0470624262182418
GO:0004806	triacylglycerol lipase activity	0.0491049780645851
GO:0001906	cell killing	0.0491049780645851
GO:0050852	T cell receptor signaling pathway	0.0491049780645851
GO:0055088	lipid homeostasis	0.0491049780645851
GO:0048029	monosaccharide binding	0.0491049780645851
GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer	0.0491049780645851
GO:0015485	cholesterol binding	0.0491049780645851

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
metabolising cell	2.24e-42	12
endopolyploid cell	2.24e-42	12
parenchymal cell	2.24e-42	12
polyploid cell	2.24e-42	12
hepatocyte	2.24e-42	12
endodermal cell	5.72e-15	58

Uber Anatomy

Ontology term	p-value	n
liver	2.27e-47	19
digestive gland	2.27e-47	19
liver bud	2.27e-47	19
hepatic diverticulum	7.55e-41	22
liver primordium	7.55e-41	22
digestive tract diverticulum	4.73e-39	23
epithelial sac	6.89e-36	25
epithelium of foregut-midgut junction	6.89e-36	25
anatomical boundary	6.89e-36	25
hepatobiliary system	6.89e-36	25
foregut-midgut junction	6.89e-36	25
septum transversum	6.89e-36	25
sac	1.73e-34	26
exocrine gland	7.68e-29	31
exocrine system	7.68e-29	31
endocrine gland	1.76e-25	35
gut epithelium	2.39e-25	54
abdomen element	1.57e-20	54
abdominal segment element	1.57e-20	54
endocrine system	1.10e-19	45
gland	9.69e-19	59
abdominal segment of trunk	2.14e-18	60
abdomen	2.14e-18	60
endo-epithelium	2.28e-16	82
subdivision of digestive tract	2.58e-13	118
foregut	2.02e-12	87
digestive system	1.24e-10	145
digestive tract	1.24e-10	145
primitive gut	1.24e-10	145
trunk region element	1.42e-10	101
endoderm-derived structure	1.59e-09	160
endoderm	1.59e-09	160
presumptive endoderm	1.59e-09	160
subdivision of trunk	1.92e-09	112
immaterial anatomical entity	5.33e-09	117
trunk mesenchyme	1.34e-08	122
unilaminar epithelium	1.36e-08	148
epithelial tube	4.01e-07	117

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
MA0003.1	0.00191735
MA0004.1	0.472922
MA0006.1	0.00313781
MA0007.1	1.22866
MA0009.1	0.049269
MA0014.1	0.00487621
MA0017.1	5.12465
MA0019.1	0.134243
MA0024.1	0.0246296
MA0025.1	1.09463
MA0027.1	1.30259
MA0028.1	0.0123605
MA0029.1	0.834777
MA0030.1	0.799083
MA0031.1	0.911702
MA0038.1	0.305883
MA0040.1	0.291184
MA0041.1	0.0344866
MA0042.1	0.287354
MA0043.1	0.185158
MA0046.1	8.48641
MA0048.1	0.408702
MA0050.1	0.00725441
MA0051.1	0.00145249
MA0052.1	0.545567
MA0055.1	0.107375
MA0056.1	0
MA0057.1	0.136517
MA0058.1	0.276679
MA0059.1	1.09673
MA0060.1	0.0244967
MA0061.1	0.0759327
MA0063.1	0
MA0066.1	2.26971
MA0067.1	0.190212
MA0068.1	1.89255
MA0069.1	0.172185
MA0070.1	0.371416
MA0071.1	1.91212
MA0072.1	0.652114
MA0073.1	7.294e-06
MA0074.1	0.0343414
MA0076.1	0.00681866
MA0077.1	0.633425
MA0078.1	0.55842
MA0081.1	0.111671
MA0083.1	0.191527
MA0084.1	0.841536
MA0087.1	0.36052
MA0088.1	0.00976753
MA0089.1	0
MA0090.1	0.379172
MA0091.1	0.212704
MA0092.1	0.496173
MA0093.1	0.815816
MA0095.1	0
MA0098.1	0
MA0100.1	0.740053
MA0101.1	0.0223386
MA0103.1	0.436911
MA0105.1	0.0295282
MA0106.1	1.83728
MA0107.1	0.0303281
MA0108.2	1.2535
MA0109.1	0
MA0111.1	1.49262
MA0113.1	0.14853
MA0114.1	8.26834
MA0115.1	0.885511
MA0116.1	0.760991
MA0117.1	0.0607969
MA0119.1	0.0234078
MA0122.1	0.895957
MA0124.1	0.795162
MA0125.1	0.0892736
MA0130.1	0
MA0131.1	0.0359933
MA0132.1	0
MA0133.1	0
MA0135.1	0.212475
MA0136.1	0.322087
MA0139.1	0.454802
MA0140.1	1.2451
MA0141.1	4.76283
MA0142.1	0.153597
MA0143.1	0.451115
MA0144.1	1.20708
MA0145.1	0.13731
MA0146.1	0.0337363
MA0147.1	0.214895
MA0148.1	1.01219
MA0149.1	0.000664761
MA0062.2	8.69994e-05
MA0035.2	0.966417
MA0039.2	0.00512062
MA0138.2	1.12019
MA0002.2	1.1772
MA0137.2	0.972322
MA0104.2	0.144224
MA0047.2	0.37548
MA0112.2	0.922297
MA0065.2	5.52651
MA0150.1	0.357939
MA0151.1	0
MA0152.1	0.546979
MA0153.1	4.8083
MA0154.1	0.282403
MA0155.1	0.695522
MA0156.1	0.0617214
MA0157.1	0.455691
MA0158.1	0
MA0159.1	1.57066
MA0160.1	1.10754
MA0161.1	0
MA0162.1	4.67743e-05
MA0163.1	0.0101998
MA0164.1	0.163539
MA0080.2	0.122656
MA0018.2	0.0566924
MA0099.2	0.23303
MA0079.2	3.27777e-08
MA0102.2	0.340338
MA0258.1	1.91517
MA0259.1	0.245637
MA0442.1	0

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
EP300#2033	33	1.60820199255659	0.00340127413872385	0.0173543245773697
FOSL2#2355	18	2.19240007828856	0.00145706039150538	0.00933639672546967
FOXA1#3169	27	2.15250599448494	0.000113671131355055	0.00155653589715361
FOXA2#3170	24	4.25274194290623	2.1972029910603e-09	1.8809318293717e-07
HDAC2#3066	29	2.79894235152634	3.78007892975108e-07	1.84998905034805e-05
HEY1#23462	55	1.59860508899866	8.22381484540393e-05	0.00123669834217299
HNF4A#3172	28	4.65974194361657	9.82980288562775e-12	1.23095297790417e-09
HNF4G#3174	25	5.17147887166309	1.68827079468272e-11	2.05024783169615e-09
RXRA#6256	29	4.18822947507097	4.98562353858421e-11	5.61092173217884e-09
SP1#6667	38	1.55783088035507	0.00272571104218793	0.014970053404242
TCF7L2#6934	22	1.70463226179152	0.00936131921436626	0.0353517073123083

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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