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Coexpression cluster:C4804: Difference between revisions

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{{Coexpression_clusters
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|full_id=C4804_Placental_amniotic_Smooth_chorionic_Amniotic_Mesothelial_Fibroblast
|id=C4804
|ontology_enrichment_celltype=CL:0000055!1.25e-14!180;CL:0000680!5.55e-08!57;CL:0000056!5.55e-08!57;CL:0000355!5.55e-08!57;CL:0000187!6.64e-08!54;CL:0000183!3.21e-07!59;CL:0000057!3.91e-07!75
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0000468!2.79e-14!659;UBERON:0000481!1.72e-13!347;UBERON:0003104!2.87e-12!238;UBERON:0009142!2.87e-12!238;UBERON:0004923!4.77e-12!57;UBERON:0000475!5.36e-12!365;UBERON:0000062!5.37e-12!511;UBERON:0002100!1.23e-11!216;UBERON:0000467!1.41e-11!625;UBERON:0000480!2.34e-11!626;UBERON:0003102!5.08e-10!95;UBERON:0000486!7.77e-10!82;UBERON:0000064!1.02e-09!219;UBERON:0005631!1.51e-09!14;UBERON:0000158!1.51e-09!14;UBERON:0000923!1.54e-09!604;UBERON:0005291!1.54e-09!604;UBERON:0006598!1.54e-09!604;UBERON:0002532!1.54e-09!604;UBERON:0002050!1.76e-09!605;UBERON:0005423!1.76e-09!605;UBERON:0000922!2.84e-09!612;UBERON:0005256!2.97e-09!143;UBERON:0000914!5.43e-09!83;UBERON:0002329!5.43e-09!83;UBERON:0003077!5.43e-09!83;UBERON:0003059!5.43e-09!83;UBERON:0007282!5.43e-09!83;UBERON:0009618!5.43e-09!83;UBERON:0007285!5.43e-09!83;UBERON:0004290!1.29e-08!70;UBERON:0004119!1.41e-08!169;UBERON:0000925!1.41e-08!169;UBERON:0006595!1.41e-08!169;UBERON:0000926!1.71e-08!448;UBERON:0004120!1.71e-08!448;UBERON:0006603!1.71e-08!448;UBERON:0001444!1.92e-08!48;UBERON:0001134!2.88e-07!61;UBERON:0002036!2.88e-07!61;UBERON:0003082!2.88e-07!61;UBERON:0002385!3.43e-07!63;UBERON:0001015!3.43e-07!63;UBERON:0000383!3.43e-07!63;UBERON:0001007!4.76e-07!155;UBERON:0001555!4.76e-07!155;UBERON:0007026!4.76e-07!155;UBERON:0000161!9.76e-07!35
}}

Latest revision as of 14:20, 17 September 2013


Full id: C4804_Placental_amniotic_Smooth_chorionic_Amniotic_Mesothelial_Fibroblast



Phase1 CAGE Peaks

Hg19::chr9:132515289..132515300,-p3@PTGES
Hg19::chr9:132515302..132515338,-p1@PTGES
Hg19::chr9:132515340..132515357,-p2@PTGES


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
muscle precursor cell6.02e-0858
myoblast6.02e-0858
multi-potent skeletal muscle stem cell6.02e-0858
muscle cell7.81e-0855
non-terminally differentiated cell1.07e-07106
contractile cell1.53e-0759
extraembryonic cell3.61e-0719
Uber Anatomy
Ontology termp-valuen
organism subdivision8.04e-17264
organ component layer5.86e-1366
multi-cellular organism9.59e-12656
trunk5.88e-11199
multi-tissue structure1.58e-10342
organ2.91e-10503
organ part5.20e-10218
anatomical system6.77e-10624
surface structure8.89e-1099
anatomical group9.72e-10625
multilaminar epithelium1.06e-0983
extraembryonic membrane1.34e-0914
membranous layer1.34e-0914
mesenchyme6.02e-09160
entire embryonic mesenchyme6.02e-09160
somite1.63e-0871
presomitic mesoderm1.63e-0871
presumptive segmental plate1.63e-0871
dermomyotome1.63e-0871
trunk paraxial mesoderm1.63e-0871
subdivision of head2.62e-0849
dense mesenchyme tissue3.23e-0873
paraxial mesoderm3.34e-0872
presumptive paraxial mesoderm3.34e-0872
epithelial vesicle1.03e-0778
head2.39e-0756
skeletal muscle tissue3.55e-0762
striated muscle tissue3.55e-0762
myotome3.55e-0762
muscle tissue4.45e-0764
musculature4.45e-0764
musculature of body4.45e-0764
trunk mesenchyme6.61e-07122
orifice8.33e-0736
endoderm-derived structure9.57e-07160
endoderm9.57e-07160
presumptive endoderm9.57e-07160


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.13.15032
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.11.70014
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.990225
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.14.49708
MA0145.10.273764
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.22.07011
MA0039.23.37171
MA0138.21.04628
MA0002.21.20011
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.731309
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.8915
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.941469
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195834.988179094810140.008056488137383440.0322862347791792
IRF1#365937.63716375356390.002244692747297240.012883791263738
MAX#414936.452555509007120.003721913834265510.0187584672781032
MYC#460935.22228187160940.007020843755740150.0296430263990033
RAD21#5885310.35503389545630.0009004912073565420.00669369403595088
TFAP2A#7020316.5186343730450.0002218033880766340.00249783524340474
TFAP2C#7022310.80922860986020.0007916746575753130.00619524273658835



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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