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{{Coexpression_clusters
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82769,0.264413,0.131761,0.160658,0.206239,0.0015491,0.28689,0.236464,0.00756988,0.115817,0.218052,0.00224487,0.11528,0.194982,0.190993,0.281727,0.283218,0.249955,0.164638,0.224257,0.0935776,0.327622,0.225752,0.207791,0.0958756,0.0859274,0.316866,0.0156618,0.158847,0.271275,0.071111,0.00414049,0.101021,0.222548,0.175934,0.0130722,0.00199458,0.035048,0.205954,0.361435|tfbs_overrepresentation_for_novel_motifs=0.699513,1.40091,0.690871,0.855819,0.641468,0.853988,0.937929,0.494933,0.491742,0.221898,0.820209,0.985163,0.436625,0.925331,0.639839,0.667627,1.17594,0.575162,0.452865,0.305559,0.69094,0.242883,0.845342,0.635379,0.743951,1.00973,0.409304,0.842925,0.645155,0.388328,0.795576,1.21459,0.534793,0.439574,0.599922,0.427404,0.596053,0.855276,1.39264,3.05174,0.598234,0.777097,0.259059,0.63803,0.461452,0.726632,0.939121,0.808003,0.247669,0.645308,1.02504,0.951993,0.336258,1.29475,1.45259,0.928548,0.650353,0.892517,1.0078,0.891404,1.25741,0.941709,0.492369,1.14672,0.961293,1.11026,1.54311,1.91674,1.2037,1.75271,0.762094,0.502203,2.41357,1.45054,1.10051,0.414196,0.396746,1.12884,1.20029,0.73687,0.459024,1.14559,0.960908,0.498519,1.39759,5.52876,0.82001,1.76229,1.053,2.0169,1.63834,1.36973,1.23218,0.543775,0.642354,0.560075,1.14422,1.27663,1.05794,0.360456,0.569121,1.22626,1.27082,1.1798,1.09802,0.815119,1.16312,0.921547,0.743661,0.622396,1.67826,1.26794,0.684398,0.830777,1.58942,0.594137,1.66424,0.794219,4.07533,0.547323,1.44203,1.0504,0.850918,0.973172,1.70203,1.12965,0.930979,1.2374,1.48578,0.561252,1.37044,0.798812,1.50051,0.969553,1.65144,0.372828,0.788803,0.843556,1.60823,2.47382,2.06967,1.57016,0.932872,1.27296,1.09989,0.883164,1.08214,2.31409,0.773313,0.539692,4.20421,1.99724,1.37083,0.481626,0.941179,1.78371,1.03563,0.624795,1.76124,0.710709,1.56892,1.35169,1.19946,0.714443,1.11698,2.20464,2.24188,0.936473,0.265282|tfbs_overrepresentation_jaspar=MA0003.1;0.178364,MA0004.1;1.93041,MA0006.1;0.639288,MA0007.1;0.804807,MA0009.1;1.3275,MA0014.1;2.44638,MA0017.1;0.686276,MA0019.1;0.990656,MA0024.1;1.21731,MA0025.1;1.46617,MA0027.1;2.95767,MA0028.1;0.658629,MA0029.1;1.23771,MA0030.1;1.22561,MA0031.1;1.15713,MA0038.1;0.94098,MA0040.1;1.24388,MA0041.1;0.847069,MA0042.1;0.810843,MA0043.1;1.32783,MA0046.1;1.31611,MA0048.1;0.341392,MA0050.1;0.81185,MA0051.1;0.936307,MA0052.1;1.24796,MA0055.1;0.190716,MA0056.1;0,MA0057.1;6.48547,MA0058.1;0.716037,MA0059.1;1.70014,MA0060.1;2.13518,MA0061.1;0.456531,MA0063.1;0,MA0066.1;0.941452,MA0067.1;1.65513,MA0068.1;0.405474,MA0069.1;1.31207,MA0070.1;1.30033,MA0071.1;0.897953,MA0072.1;1.29561,MA0073.1;0.990225,MA0074.1;0.935474,MA0076.1;0.734647,MA0077.1;1.28751,MA0078.1;1.04495,MA0081.1;1.70054,MA0083.1;1.33535,MA0084.1;1.84562,MA0087.1;1.29304,MA0088.1;2.03569,MA0089.1;0,MA0090.1;0.751469,MA0091.1;0.829044,MA0092.1;0.785956,MA0093.1;2.626,MA0095.1;0,MA0098.1;0,MA0100.1;0.956299,MA0101.1;0.646932,MA0103.1;0.628063,MA0105.1;0.31555,MA0106.1;0.986396,MA0107.1;0.556367,MA0108.2;1.15387,MA0109.1;0,MA0111.1;0.767139,MA0113.1;1.00436,MA0114.1;0.549955,MA0115.1;1.57693,MA0116.1;0.560723,MA0117.1;1.36676,MA0119.1;0.695578,MA0122.1;1.39371,MA0124.1;1.53432,MA0125.1;1.44766,MA0130.1;0,MA0131.1;1.06461,MA0132.1;0,MA0133.1;0,MA0135.1;1.35921,MA0136.1;0.948776,MA0139.1;1.12079,MA0140.1;0.894983,MA0141.1;0.712476,MA0142.1;1.12317,MA0143.1;1.00455,MA0144.1;0.531867,MA0145.1;0.273764,MA0146.1;0.348055,MA0147.1;2.37462,MA0148.1;0.854239,MA0149.1;3.38595,MA0062.2;0.449458,MA0035.2;0.894194,MA0039.2;2.15877,MA0138.2;1.04628,MA0002.2;0.476938,MA0137.2;0.666381,MA0104.2;1.2307,MA0047.2;0.973066,MA0112.2;0.264678,MA0065.2;2.13692,MA0150.1;0.744617,MA0151.1;0,MA0152.1;0.902317,MA0153.1;1.43021,MA0154.1;0.312019,MA0155.1;0.711948,MA0156.1;0.669101,MA0157.1;1.09377,MA0158.1;0,MA0159.1;0.565904,MA0160.1;0.871361,MA0161.1;0,MA0162.1;0.149099,MA0163.1;1.2663,MA0164.1;1.01792,MA0080.2;0.643061,MA0018.2;0.987913,MA0099.2;0.902716,MA0079.2;10.8725,MA0102.2;1.88331,MA0258.1;0.519674,MA0259.1;1.40979,MA0442.1;0}}
|full_id=C4679_clear_Smooth_Mesothelial_Alveolar_Renal_gastric_mesothelioma
|id=C4679
|ontology_enrichment_celltype=CL:0000222!1.95e-14!119;CL:1000497!2.26e-11!18;CL:0002518!2.26e-11!18;CL:0000213!2.41e-10!57;CL:0000215!2.41e-10!57;CL:1000449!4.53e-10!16;CL:0002078!3.37e-09!44;CL:0000076!4.95e-08!62;CL:0002681!5.02e-08!13;CL:0002584!5.02e-08!13;CL:1000507!5.06e-08!12;CL:1000494!5.06e-08!12;CL:0002139!1.12e-07!24;CL:0000115!1.67e-07!35
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0003914!5.65e-17!118;UBERON:0000489!2.82e-15!32;UBERON:0009569!4.24e-15!113;UBERON:0000055!6.51e-13!69;UBERON:0002113!1.51e-12!27;UBERON:0003918!1.51e-12!27;UBERON:0005095!1.51e-12!27;UBERON:0007687!1.51e-12!27;UBERON:0002100!1.54e-12!216;UBERON:0002417!4.77e-12!61;UBERON:0000916!4.77e-12!61;UBERON:0001008!7.88e-12!45;UBERON:0003103!8.32e-12!69;UBERON:0001981!1.38e-11!60;UBERON:0007500!1.38e-11!60;UBERON:0004537!1.38e-11!60;UBERON:0006965!1.38e-11!60;UBERON:0006554!2.58e-11!44;UBERON:0005172!7.00e-11!55;UBERON:0005173!7.00e-11!55;UBERON:0000080!9.64e-11!18;UBERON:0002120!9.64e-11!18;UBERON:0004875!9.64e-11!18;UBERON:0005721!9.64e-11!18;UBERON:0005754!9.64e-11!18;UBERON:0007297!9.64e-11!18;UBERON:0006555!1.16e-10!17;UBERON:0005103!1.16e-10!17;UBERON:0000083!1.16e-10!17;UBERON:0009201!1.16e-10!17;UBERON:0004819!1.16e-10!17;UBERON:0006553!1.16e-10!17;UBERON:0003074!1.16e-10!17;UBERON:0003060!1.16e-10!17;UBERON:0005177!1.54e-10!107;UBERON:0003887!1.82e-10!21;UBERON:0004876!4.23e-10!20;UBERON:0004211!4.53e-10!16;UBERON:0001285!4.53e-10!16;UBERON:0007684!4.53e-10!16;UBERON:0003220!4.53e-10!16;UBERON:0004208!4.53e-10!16;UBERON:0003064!1.19e-09!37;UBERON:0004111!1.84e-09!241;UBERON:0000025!2.97e-09!194;UBERON:0002049!3.92e-09!79;UBERON:0007798!3.92e-09!79;UBERON:0003104!5.64e-09!238;UBERON:0009142!5.64e-09!238;UBERON:0001637!5.85e-09!42;UBERON:0003509!5.85e-09!42;UBERON:0004572!5.85e-09!42;UBERON:0004872!7.21e-09!84;UBERON:0000483!1.02e-08!309;UBERON:0000490!1.47e-08!138;UBERON:0005256!2.90e-08!143;UBERON:0000119!3.45e-08!312;UBERON:0001225!5.02e-08!13;UBERON:0008987!5.02e-08!13;UBERON:0009773!5.06e-08!12;UBERON:0001231!5.06e-08!12;UBERON:0004810!5.06e-08!12;UBERON:0001851!3.44e-07!16;UBERON:0000926!5.75e-07!448;UBERON:0004120!5.75e-07!448;UBERON:0006603!5.75e-07!448;UBERON:0003886!6.58e-07!63;UBERON:0000058!8.07e-07!26
}}

Latest revision as of 14:17, 17 September 2013


Full id: C4679_clear_Smooth_Mesothelial_Alveolar_Renal_gastric_mesothelioma



Phase1 CAGE Peaks

Hg19::chr7:27170274..27170308,-p3@HOXA4
Hg19::chr7:27170324..27170335,-p7@HOXA4
Hg19::chr7:27170359..27170381,-p1@HOXA4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
epithelial tube1.76e-14117
epithelial tube open at both ends1.09e-1259
blood vessel1.09e-1259
blood vasculature1.09e-1259
vascular cord1.09e-1259
vessel1.68e-1268
cavitated compound organ1.76e-1231
subdivision of trunk1.82e-12112
trunk1.32e-11199
kidney4.38e-1026
kidney mesenchyme4.38e-1026
upper urinary tract4.38e-1026
kidney rudiment4.38e-1026
kidney field4.38e-1026
vasculature1.51e-0978
vascular system1.51e-0978
artery1.61e-0942
arterial blood vessel1.61e-0942
arterial system1.61e-0942
tube2.06e-09192
mesenchyme3.90e-09160
entire embryonic mesenchyme3.90e-09160
splanchnic layer of lateral plate mesoderm4.70e-0983
excretory tube8.47e-0916
kidney epithelium8.47e-0916
epithelium9.24e-09306
compound organ1.35e-0868
cell layer2.33e-08309
abdominal segment of trunk2.96e-0860
abdomen2.96e-0860
nephron epithelium5.12e-0815
renal tubule5.12e-0815
nephron tubule5.12e-0815
nephron5.12e-0815
uriniferous tubule5.12e-0815
nephrogenic mesenchyme5.12e-0815
systemic artery1.08e-0733
systemic arterial system1.08e-0733
anatomical conduit1.69e-07240
epithelial vesicle2.70e-0778
trunk region element3.61e-07101
anatomical cluster4.26e-07373
simple squamous epithelium4.97e-0722
muscle tissue5.78e-0764
musculature5.78e-0764
musculature of body5.78e-0764
squamous epithelium6.01e-0725
blood vessel endothelium6.96e-0718
endothelium6.96e-0718
cardiovascular system endothelium6.96e-0718
unilaminar epithelium9.42e-07148
aorta9.99e-0721
aortic system9.99e-0721


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.12.44638
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.16.48547
MA0058.10.716037
MA0059.11.70014
MA0060.12.13518
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.990225
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.11.70054
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.12.03569
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.11.12079
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.348055
MA0147.12.37462
MA0148.10.854239
MA0149.13.38595
MA0062.20.449458
MA0035.20.894194
MA0039.22.15877
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.21.2307
MA0047.20.973066
MA0112.20.264678
MA0065.22.13692
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.210.8725
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ATF3#467322.46317452600878.81932387510763e-050.00130041135986498
CHD2#1106310.34402283411690.0009033701102746880.00662735817272957
E2F1#186934.907389214879320.008460985347239390.0327656512544156
ELF1#199734.258097958807540.01295179875054610.0464883977629406
GABPB1#255337.067683836182170.002832212825417420.0154792754866173
MAX#414936.452555509007120.003721913834265510.0187385730301222
MYC#460935.22228187160940.007020843755740150.0296023375456498
NANOG#79923329.24477848101273.99627955670032e-050.000741064347695712
SUZ12#23512350.11578091106297.93834897779404e-060.000223469873016666
TCF7L2#6934310.77017656313730.0008003181298398380.00617314809175354
USF1#739136.361499277207960.00388404057290560.0191161787650183
USF2#7392312.99219738506960.0004558979393427810.00423156104577148



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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