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{{Coexpression_clusters
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|full_id=C4394_neuroblastoma_Mesenchymal_rectum_heart_neuroectodermal_leiomyoma_gall
|gostat_on_coexpression_clusters=GO:0007507!heart development!0.038276619961537!9464$GO:0001525!angiogenesis!0.038276619961537!9464$GO:0048514!blood vessel morphogenesis!0.038276619961537!9464$GO:0048646!anatomical structure formation!0.038276619961537!9464$GO:0001568!blood vessel development!0.038276619961537!9464$GO:0001944!vasculature development!0.038276619961537!9464
|id=C4394
}}

Latest revision as of 12:45, 17 September 2013


Full id: C4394_neuroblastoma_Mesenchymal_rectum_heart_neuroectodermal_leiomyoma_gall



Phase1 CAGE Peaks

Hg19::chr4:174451350..174451363,-p3@HAND2
Hg19::chr4:174451370..174451387,-p1@HAND2
Hg19::chr4:174451596..174451632,+p1@NBLA00301


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0007507heart development0.038276619961537
GO:0001525angiogenesis0.038276619961537
GO:0048514blood vessel morphogenesis0.038276619961537
GO:0048646anatomical structure formation0.038276619961537
GO:0001568blood vessel development0.038276619961537
GO:0001944vasculature development0.038276619961537



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
splanchnic layer of lateral plate mesoderm1.32e-1683
primary circulatory organ8.45e-1627
heart3.28e-1324
primitive heart tube3.28e-1324
primary heart field3.28e-1324
anterior lateral plate mesoderm3.28e-1324
heart tube3.28e-1324
heart primordium3.28e-1324
cardiac mesoderm3.28e-1324
cardiogenic plate3.28e-1324
heart rudiment3.28e-1324
extraembryonic structure1.52e-1224
muscle tissue2.85e-1164
musculature2.85e-1164
musculature of body2.85e-1164
epithelial tube2.54e-10117
skeletal muscle tissue3.67e-1062
striated muscle tissue3.67e-1062
myotome3.67e-1062
somite5.90e-1071
presomitic mesoderm5.90e-1071
presumptive segmental plate5.90e-1071
dermomyotome5.90e-1071
trunk paraxial mesoderm5.90e-1071
mesoderm6.14e-10315
mesoderm-derived structure6.14e-10315
presumptive mesoderm6.14e-10315
circulatory system6.96e-10112
paraxial mesoderm1.27e-0972
presumptive paraxial mesoderm1.27e-0972
extraembryonic membrane1.95e-0914
membranous layer1.95e-0914
artery2.08e-0942
arterial blood vessel2.08e-0942
arterial system2.08e-0942
dense mesenchyme tissue2.66e-0973
multi-cellular organism3.36e-09656
mesenchyme7.15e-09160
entire embryonic mesenchyme7.15e-09160
epithelial tube open at both ends8.08e-0959
blood vessel8.08e-0959
blood vasculature8.08e-0959
vascular cord8.08e-0959
cardiovascular system1.76e-08109
trunk mesenchyme2.40e-08122
epithelial vesicle7.49e-0878
multilaminar epithelium1.39e-0783
systemic artery6.99e-0733
systemic arterial system6.99e-0733
vessel9.22e-0768
organ component layer9.51e-0766


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.12.92613
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.19.77185
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.12.26659
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.11.55947
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.11.36919
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.13.19113
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.12.26598
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.27.52072
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203336.77394172622320.003216880500103790.0168059518058296
YY1#752834.911170749853860.008441455341808260.0330614698283624



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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