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{{Coexpression_clusters
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|full_id=C2630_extraskeletal_Fibroblast_Smooth_Aortic_mesothelioma_prostate_small
|id=C2630
|ontology_enrichment_celltype=CL:0000066!2.12e-15!254
|ontology_enrichment_disease=DOID:0050687!1.04e-31!143;DOID:305!2.17e-29!106;DOID:162!5.94e-23!235;DOID:14566!2.71e-21!239;DOID:299!3.62e-12!25
|ontology_enrichment_uberon=UBERON:0003104!3.06e-16!238;UBERON:0009142!3.06e-16!238;UBERON:0000481!6.70e-13!347;UBERON:0002100!1.38e-10!216;UBERON:0005177!7.47e-09!107;UBERON:0005256!4.02e-08!143;UBERON:0000475!7.04e-08!365;UBERON:0001007!7.87e-08!155;UBERON:0001555!7.87e-08!155;UBERON:0007026!7.87e-08!155;UBERON:0000077!1.08e-07!130;UBERON:0003064!1.67e-07!37;UBERON:0004119!2.20e-07!169;UBERON:0000925!2.20e-07!169;UBERON:0006595!2.20e-07!169;UBERON:0000466!2.74e-07!126;UBERON:0002113!3.32e-07!27;UBERON:0003918!3.32e-07!27;UBERON:0005095!3.32e-07!27;UBERON:0007687!3.32e-07!27;UBERON:0000464!3.52e-07!104;UBERON:0001041!4.21e-07!98;UBERON:0000072!5.71e-07!46;UBERON:0004921!6.15e-07!129;UBERON:0004185!6.15e-07!129;UBERON:0006554!9.21e-07!44
|tf_chipseq_enrich=E2F6#1876;4:5.01715573169739:0.0015780219347306:0.00997681656524783!EGR1#1958;4:4.98817909481014:0.00161501150007605:0.0101516813756511!MXI1#4601;4:9.9615716287593:0.000101522475495045:0.00142531332413321!MYC#4609;4:5.2222818716094:0.00134430939527274:0.00888428329639242!SUZ12#23512;4:50.1157809110629:1.5827390373096e-07:8.82539681353859e-06!TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0322620634494329!USF1#7391;4:6.36149927720796:0.000610501139914083:0.00508413432353775!ZNF263#10127;4:8.22184163701068:0.000218787118095832:0.00249235469315124
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}}

Latest revision as of 12:09, 17 September 2013


Full id: C2630_extraskeletal_Fibroblast_Smooth_Aortic_mesothelioma_prostate_small



Phase1 CAGE Peaks

Hg19::chr21:38071403..38071428,+p2@SIM2
Hg19::chr21:38071430..38071456,+p1@SIM2
Hg19::chr21:38071462..38071474,+p3@SIM2
Hg19::chr21:38071488..38071502,+p4@SIM2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell4.31e-18253
kidney tubule cell5.69e-0710
nephron tubule epithelial cell5.69e-0710
Uber Anatomy
Ontology termp-valuen
multi-tissue structure1.41e-11342
trunk5.60e-11199
trunk region element1.40e-09101
mesenchyme2.91e-09160
entire embryonic mesenchyme2.91e-09160
organism subdivision3.32e-09264
segment of respiratory tract1.50e-0747
larynx1.53e-079
kidney2.58e-0726
kidney mesenchyme2.58e-0726
upper urinary tract2.58e-0726
kidney rudiment2.58e-0726
kidney field2.58e-0726
nephron tubule epithelium5.69e-0710
digestive system9.08e-07145
digestive tract9.08e-07145
primitive gut9.08e-07145
Disease
Ontology termp-valuen
cell type cancer7.98e-37143
carcinoma2.20e-34106
cancer3.07e-28235
disease of cellular proliferation1.18e-26239
adenocarcinoma1.68e-1325
squamous cell carcinoma7.52e-0814
gastrointestinal system cancer6.44e-0714


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.8989
MA0004.12.8475
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.16.90671
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.12.49947
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.14.57701
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.12.54366
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.11.18043
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.11.6149
MA0093.13.35176
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.11.22348
MA0106.10.869173
MA0107.11.1497
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.11.15856
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.569905
MA0146.11.25938
MA0147.13.01834
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.483275
MA0138.20.928035
MA0002.20.379056
MA0137.22.35208
MA0104.23.68813
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.11.88496
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.12.03616
MA0160.10.756582
MA0161.10
MA0162.15.0369
MA0163.10.918944
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.218.3958
MA0102.21.75932
MA0258.10.418966
MA0259.12.06681
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
E2F6#187645.017155731697390.00157802193473060.00997681656524783
EGR1#195844.988179094810140.001615011500076050.0101516813756511
MXI1#460149.96157162875930.0001015224754950450.00142531332413321
MYC#460945.22228187160940.001344309395272740.00888428329639242
SUZ12#23512450.11578091106291.5827390373096e-078.82539681353859e-06
TAF1#687243.343046285745290.008005664898701650.0322620634494329
USF1#739146.361499277207960.0006105011399140830.00508413432353775
ZNF263#1012748.221841637010680.0002187871180958320.00249235469315124



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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