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{{Coexpression_clusters
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receptor protein phosphatase activity!0.0316304946493676!5794$GO:0005001!transmembrane receptor protein tyrosine phosphatase activity!0.0316304946493676!5794$GO:0022603!regulation of anatomical structure morphogenesis!0.0316304946493676!54751$GO:0008360!regulation of cell shape!0.0316304946493676!54751$GO:0022604!regulation of cell morphogenesis!0.0316304946493676!54751$GO:0044459!plasma membrane 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|full_id=C1341_smallcell_small_gall_colon_temporal_signet_adenocarcinoma
|gostat_on_coexpression_clusters=GO:0019198!transmembrane receptor protein phosphatase activity!0.0316304946493676!5794$GO:0005001!transmembrane receptor protein tyrosine phosphatase activity!0.0316304946493676!5794$GO:0022603!regulation of anatomical structure morphogenesis!0.0316304946493676!54751$GO:0008360!regulation of cell shape!0.0316304946493676!54751$GO:0022604!regulation of cell morphogenesis!0.0316304946493676!54751$GO:0044459!plasma membrane part!0.0482371433811814!5794;54751
|id=C1341
|ontology_enrichment_celltype=CL:0000066!6.05e-36!254;CL:0000223!3.82e-12!59;CL:0000076!6.83e-12!62;CL:0002076!1.73e-11!43;CL:0002139!4.11e-10!24;CL:0000071!2.73e-08!18;CL:0002546!2.73e-08!18;CL:0002078!1.11e-07!44;CL:1000497!2.96e-07!18;CL:0002518!2.96e-07!18
|ontology_enrichment_disease=DOID:305!2.87e-18!106;DOID:0050687!6.06e-12!143;DOID:299!8.85e-09!25
|ontology_enrichment_uberon=UBERON:0004119!8.02e-16!169;UBERON:0000925!8.02e-16!169;UBERON:0006595!8.02e-16!169;UBERON:0001007!8.90e-15!155;UBERON:0001555!8.90e-15!155;UBERON:0007026!8.90e-15!155;UBERON:0004921!1.35e-13!129;UBERON:0004185!1.35e-13!129;UBERON:0000464!6.56e-13!104;UBERON:0000466!2.95e-12!126;UBERON:0005177!1.66e-11!107;UBERON:0000077!7.76e-11!130;UBERON:0005409!3.04e-09!35;UBERON:0001041!1.13e-08!98;UBERON:0001008!1.42e-08!45;UBERON:0009569!1.64e-08!113;UBERON:0002553!2.13e-08!70;UBERON:0003887!2.25e-08!21;UBERON:0001986!2.73e-08!18;UBERON:0004638!2.73e-08!18;UBERON:0004852!2.73e-08!18;UBERON:0006554!3.97e-08!44;UBERON:0000058!4.73e-08!26;UBERON:0003064!4.75e-08!37;UBERON:0000487!8.02e-08!22;UBERON:0005911!2.29e-07!82;UBERON:0000080!3.29e-07!18;UBERON:0002120!3.29e-07!18;UBERON:0004875!3.29e-07!18;UBERON:0005721!3.29e-07!18;UBERON:0005754!3.29e-07!18;UBERON:0007297!3.29e-07!18;UBERON:0001004!4.16e-07!72;UBERON:0004876!5.33e-07!20;UBERON:0002075!7.90e-07!18;UBERON:0002113!9.89e-07!27;UBERON:0003918!9.89e-07!27;UBERON:0005095!9.89e-07!27;UBERON:0007687!9.89e-07!27
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}}

Latest revision as of 11:42, 17 September 2013


Full id: C1341_smallcell_small_gall_colon_temporal_signet_adenocarcinoma



Phase1 CAGE Peaks

Hg19::chr11:441952..441963,-p2@ANO9
Hg19::chr19:49118307..49118336,-p@chr19:49118307..49118336
-
Hg19::chr19:55720851..55720860,-p4@PTPRH
Hg19::chr19:55720862..55720880,-p1@PTPRH
Hg19::chr1:16083098..16083119,+p5@FBLIM1
Hg19::chr1:16083123..16083144,+p4@FBLIM1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0019198transmembrane receptor protein phosphatase activity0.0316304946493676
GO:0005001transmembrane receptor protein tyrosine phosphatase activity0.0316304946493676
GO:0022603regulation of anatomical structure morphogenesis0.0316304946493676
GO:0008360regulation of cell shape0.0316304946493676
GO:0022604regulation of cell morphogenesis0.0316304946493676
GO:0044459plasma membrane part0.0482371433811814



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell7.49e-19253
endodermal cell3.21e-0958
endo-epithelial cell2.91e-0742
kidney tubule cell8.35e-0710
nephron tubule epithelial cell8.35e-0710
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.19e-19160
endoderm1.19e-19160
presumptive endoderm1.19e-19160
subdivision of digestive tract2.07e-18118
digestive system4.53e-18145
digestive tract4.53e-18145
primitive gut4.53e-18145
gastrointestinal system1.54e-1425
trunk region element6.19e-14101
immaterial anatomical entity2.93e-12117
anatomical space1.43e-1095
intestine6.91e-1017
foregut9.76e-1087
endo-epithelium7.26e-0982
viscus7.76e-0818
abdomen element1.03e-0754
abdominal segment element1.03e-0754
renal system1.11e-0748
organ2.58e-07503
subdivision of trunk3.70e-07112
urinary system structure4.97e-0747
nephron tubule epithelium8.35e-0710
Disease
Ontology termp-valuen
carcinoma1.94e-14106
adenocarcinoma1.77e-1025
cell type cancer1.95e-09143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.756372
MA0004.10.558729
MA0006.10.391183
MA0007.10.539222
MA0009.11.03681
MA0014.10.788761
MA0017.11.10421
MA0019.10.7124
MA0024.10.929647
MA0025.11.17262
MA0027.12.65688
MA0028.10.408079
MA0029.10.949428
MA0030.10.937696
MA0031.10.871496
MA0038.10.665566
MA0040.10.955415
MA0041.10.578072
MA0042.10.544748
MA0043.11.03713
MA0046.11.02569
MA0048.10.464411
MA0050.10.545671
MA0051.10.661179
MA0052.10.959373
MA0055.10.465994
MA0056.10
MA0057.10.450439
MA0058.10.458909
MA0059.10.457555
MA0060.10.267412
MA0061.10.671725
MA0063.10
MA0066.10.66601
MA0067.11.35893
MA0068.10.199491
MA0069.11.02175
MA0070.11.01032
MA0071.10.625297
MA0072.11.00572
MA0073.10.51617
MA0074.10.660398
MA0076.10.475586
MA0077.10.997832
MA0078.10.763954
MA0081.10.457725
MA0083.11.04447
MA0084.11.5477
MA0087.11.00322
MA0088.10.32124
MA0089.10
MA0090.11.22966
MA0091.10.561458
MA0092.10.522012
MA0093.10.394379
MA0095.10
MA0098.10
MA0100.10.679972
MA0101.11.02896
MA0103.11.76074
MA0105.10.419295
MA0106.10.70837
MA0107.11.54633
MA0108.20.868347
MA0109.10
MA0111.11.25994
MA0113.10.725375
MA0114.13.21192
MA0115.11.28169
MA0116.10.323925
MA0117.11.07516
MA0119.10.440684
MA0122.11.10154
MA0124.11.23968
MA0125.11.15445
MA0130.10
MA0131.10.782708
MA0132.10
MA0133.10
MA0135.11.06778
MA0136.11.61362
MA0139.11.19942
MA0140.10.622527
MA0141.10.455728
MA0142.10.838805
MA0143.10.725558
MA0144.11.47313
MA0145.11.16614
MA0146.10.718193
MA0147.10.327615
MA0148.10.584698
MA0149.10.612449
MA0062.22.67639
MA0035.20.621793
MA0039.21.86512
MA0138.20.765223
MA0002.20.255126
MA0137.20.414885
MA0104.20.735746
MA0047.20.695777
MA0112.20.680553
MA0065.23.77022
MA0150.10.484557
MA0151.10
MA0152.10.629368
MA0153.11.13732
MA0154.10.819655
MA0155.13.55553
MA0156.12.81343
MA0157.10.810597
MA0158.10
MA0159.10.328286
MA0160.10.600559
MA0161.10
MA0162.10.62636
MA0163.13.1714
MA0164.10.738243
MA0080.23.70077
MA0018.20.709805
MA0099.20.629739
MA0079.23.58629
MA0102.21.58513
MA0258.10.289793
MA0259.10.893594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SMARCC1#6599214.55445310654380.007398079383140510.0305636080971445



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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