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{{Coexpression_clusters
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159.1;2.15752,MA0160.1;1.34201,MA0161.1;0,MA0162.1;0.0249953,MA0163.1;0.0167306,MA0164.1;0.678332,MA0080.2;0.344472,MA0018.2;0.650405,MA0099.2;0.572,MA0079.2;0.07638,MA0102.2;1.51913,MA0258.1;0.245543,MA0259.1;0.289405,MA0442.1;0}}
|full_id=C1249_Melanocyte_anaplastic_Wilms_retina_heart_optic_teratocarcinoma
|id=C1249
|ontology_enrichment_celltype=CL:0000147!3.28e-13!14;CL:0000148!2.94e-12!10;CL:0000541!2.94e-12!10;CL:0000047!5.49e-08!8;CL:0000133!9.80e-08!59;CL:0000710!4.52e-07!20;CL:0002322!4.59e-07!5
|ontology_enrichment_disease=
|ontology_enrichment_uberon=UBERON:0005743!1.92e-48!86;UBERON:0000073!1.09e-47!94;UBERON:0001016!1.09e-47!94;UBERON:0007023!2.81e-46!115;UBERON:0001017!9.97e-45!82;UBERON:0001049!8.28e-42!57;UBERON:0005068!8.28e-42!57;UBERON:0006241!8.28e-42!57;UBERON:0007135!8.28e-42!57;UBERON:0003075!1.12e-39!86;UBERON:0007284!1.12e-39!86;UBERON:0002346!2.68e-39!90;UBERON:0002616!2.56e-35!59;UBERON:0000955!9.40e-34!69;UBERON:0006238!9.40e-34!69;UBERON:0002780!1.26e-31!41;UBERON:0001890!1.26e-31!41;UBERON:0006240!1.26e-31!41;UBERON:0003080!1.60e-30!42;UBERON:0000924!1.38e-29!173;UBERON:0006601!1.38e-29!173;UBERON:0004121!2.44e-29!169;UBERON:0003056!5.84e-29!61;UBERON:0001893!2.60e-28!34;UBERON:0002020!3.66e-28!34;UBERON:0003528!3.66e-28!34;UBERON:0002791!2.26e-27!33;UBERON:0001869!3.35e-26!32;UBERON:0000033!6.18e-24!123;UBERON:0000153!1.39e-23!129;UBERON:0007811!1.39e-23!129;UBERON:0000956!2.34e-20!25;UBERON:0000203!2.34e-20!25;UBERON:0002619!5.86e-19!22;UBERON:0001950!1.36e-17!20;UBERON:0003076!3.77e-12!15;UBERON:0003057!3.77e-12!15;UBERON:0004732!2.35e-10!13;UBERON:0004733!2.58e-09!12;UBERON:0002028!2.58e-09!12;UBERON:0007277!2.58e-09!12;UBERON:0002308!2.98e-09!9;UBERON:0000125!2.98e-09!9;UBERON:0002420!1.10e-08!9;UBERON:0007245!1.10e-08!9;UBERON:0010009!1.10e-08!9;UBERON:0010011!1.10e-08!9;UBERON:0000454!1.10e-08!9;UBERON:0000025!2.24e-08!194;UBERON:0000064!7.15e-08!219;UBERON:0000922!2.03e-07!612;UBERON:0009663!2.04e-07!7;UBERON:0000119!2.47e-07!312;UBERON:0000062!3.07e-07!511;UBERON:0002298!3.40e-07!8;UBERON:0001871!3.61e-07!7;UBERON:0004111!3.87e-07!241;UBERON:0000483!4.74e-07!309;UBERON:0000481!4.81e-07!347
}}

Latest revision as of 11:40, 17 September 2013


Full id: C1249_Melanocyte_anaplastic_Wilms_retina_heart_optic_teratocarcinoma



Phase1 CAGE Peaks

Hg19::chr1:150230160..150230176,+p4@CA14
Hg19::chr1:150230182..150230198,+p7@CA14
Hg19::chr1:150230212..150230227,+p5@CA14
Hg19::chr1:150230231..150230242,+p6@CA14
Hg19::chr1:150230247..150230279,+p2@CA14
Hg19::chr1:150230291..150230323,+p3@CA14
Hg19::chr1:150230431..150230501,+p1@CA14


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

Cell Type
Ontology termp-valuen
pigment cell3.90e-1614
melanocyte4.74e-1410
melanoblast4.74e-1410
embryonic stem cell8.98e-105
visual pigment cell6.70e-074
Uber Anatomy
Ontology termp-valuen
adult organism1.39e-44114
neural tube6.45e-4156
neural rod6.45e-4156
future spinal cord6.45e-4156
neural keel6.45e-4156
regional part of nervous system4.07e-3753
regional part of brain4.07e-3753
central nervous system7.45e-3781
nervous system8.96e-3789
neural plate1.09e-3682
presumptive neural plate1.09e-3682
neurectoderm1.03e-3586
regional part of forebrain4.63e-2941
forebrain4.63e-2941
anterior neural tube4.63e-2941
future forebrain4.63e-2941
telencephalon5.56e-2934
brain7.45e-2968
future brain7.45e-2968
brain grey matter9.11e-2934
gray matter9.11e-2934
ecto-epithelium3.71e-28104
regional part of telencephalon3.23e-2632
cerebral hemisphere4.09e-2632
pre-chordal neural plate6.83e-2661
structure with developmental contribution from neural crest1.76e-24132
ectoderm-derived structure7.62e-22171
ectoderm7.62e-22171
presumptive ectoderm7.62e-22171
organ system subdivision4.45e-19223
cerebral cortex4.94e-1825
pallium4.94e-1825
regional part of cerebral cortex4.03e-1722
neocortex4.99e-1720
anatomical cluster3.83e-13373
neural nucleus8.10e-139
nucleus of brain8.10e-139
posterior neural tube9.03e-1315
chordal neural plate9.03e-1315
segmental subdivision of nervous system1.35e-1013
brainstem3.07e-106
telencephalic nucleus3.44e-107
basal ganglion1.00e-099
nuclear complex of neuraxis1.00e-099
aggregate regional part of brain1.00e-099
collection of basal ganglia1.00e-099
cerebral subcortex1.00e-099
tube1.79e-09192
multi-tissue structure3.44e-09342
segmental subdivision of hindbrain3.80e-0912
hindbrain3.80e-0912
presumptive hindbrain3.80e-0912
anatomical conduit3.24e-08240
occipital lobe6.99e-085
organ part2.82e-07218
retina4.66e-076
photoreceptor array4.66e-076
posterior segment of eyeball4.66e-076
layer of retina6.92e-074
epithelium8.12e-07306


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.00215847
MA0004.10.502801
MA0006.10.341337
MA0007.10.483857
MA0009.10.973289
MA0014.10.187674
MA0017.10.991615
MA0019.10.652951
MA0024.10.867125
MA0025.11.10816
MA0027.12.59001
MA0028.10.35747
MA0029.10.886702
MA0030.10.875089
MA0031.10.809638
MA0038.10.60704
MA0040.10.892629
MA0041.10.521615
MA0042.11.22641
MA0043.10.973609
MA0046.10.962263
MA0048.12.46653
MA0050.10.490116
MA0051.10.602745
MA0052.10.896548
MA0055.10.649431
MA0056.10
MA0057.10.115382
MA0058.10.406232
MA0059.10.404929
MA0060.10.224688
MA0061.10.198335
MA0063.10
MA0066.10.607474
MA0067.11.29359
MA0068.10.162298
MA0069.10.958358
MA0070.10.947018
MA0071.10.567661
MA0072.10.942461
MA0073.10.000265001
MA0074.11.46532
MA0076.10.422297
MA0077.10.934645
MA0078.10.703614
MA0081.11.04478
MA0083.10.980893
MA0084.11.48179
MA0087.10.939982
MA0088.10.0723293
MA0089.10
MA0090.10.436918
MA0091.10.505453
MA0092.10.467172
MA0093.10.344385
MA0095.10
MA0098.10
MA0100.14.99343
MA0101.10.347695
MA0103.10.332048
MA0105.10.104569
MA0106.10.648997
MA0107.10.274127
MA0108.20.806528
MA0109.10
MA0111.11.14351
MA0113.10.665691
MA0114.10.269076
MA0115.11.21667
MA0116.10.277571
MA0117.11.01134
MA0119.10.388712
MA0122.11.03753
MA0124.11.17486
MA0125.14.02117
MA0130.10
MA0131.10.722072
MA0132.10
MA0133.10
MA0135.11.00402
MA0136.10.614215
MA0139.10.186511
MA0140.10.564957
MA0141.10.403171
MA0142.10.777365
MA0143.10.66587
MA0144.10.254954
MA0145.11.46178
MA0146.10.0127148
MA0147.10.281049
MA0148.10.528066
MA0149.10.555119
MA0062.20.193221
MA0035.22.37179
MA0039.20.00276064
MA0138.21.6801
MA0002.20.611548
MA0137.20.36398
MA0104.20.223944
MA0047.20.636643
MA0112.20.0758925
MA0065.20.0828768
MA0150.10.430951
MA0151.10
MA0152.10.571637
MA0153.11.07307
MA0154.10.685508
MA0155.10.071478
MA0156.10.36627
MA0157.10.749547
MA0158.10
MA0159.12.15752
MA0160.11.34201
MA0161.10
MA0162.10.0249953
MA0163.10.0167306
MA0164.10.678332
MA0080.20.344472
MA0018.20.650405
MA0099.20.572
MA0079.20.07638
MA0102.21.51913
MA0258.10.245543
MA0259.10.289405
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
JUND#372776.994663941871031.21993360047445e-064.92686176720615e-05
POLR2A#543072.147453176558070.004747636447610280.0223491572591711
SIN3A#2594275.408884726815147.3795239773719e-060.000211675392659364
TAF1#687273.343046285745290.0002142336319622450.00246712386023872
TBP#690873.706770687096390.0001039672097505110.00145163521646172



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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