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{{Coexpression_clusters
{{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1.63287057795392,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.155405081403798,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0819873506648525,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0300822291072195,0,0,0,0,0,0,0,0,0,0,0|full_id=C70_parotid_submaxillary_salivary_throat_trachea_aorta_tongue|gostat_on_coexpression_clusters=GO:0016160!amylase activity!0.00022124418135433!279;280$GO:0004556!alpha-amylase activity!0.00022124418135433!279;280$GO:0030855!epithelial cell differentiation!0.0304966580906272!26298;1755$GO:0030670!phagocytic vesicle membrane!0.0334073818158868!1755$GO:0043152!induction of bacterial agglutination!0.0334073818158868!1755$GO:0031404!chloride ion binding!0.0334073818158868!279;280$GO:0043168!anion binding!0.0334073818158868!279;280$GO:0002009!morphogenesis of an epithelium!0.0334073818158868!26298;1755$GO:0019731!antibacterial humoral response!0.0334073818158868!1755$GO:0016889!endodeoxyribonuclease activity, producing 3'-phosphomonoesters!0.0334073818158868!58511$GO:0046676!negative regulation of insulin secretion!0.0334073818158868!131177$GO:0004531!deoxyribonuclease II activity!0.0334073818158868!58511$GO:0045335!phagocytic vesicle!0.0394176904241146!1755$GO:0019730!antimicrobial humoral response!0.0394176904241146!1755$GO:0042742!defense response to bacterium!0.0394176904241146!3347;1755$GO:0007586!digestion!0.0394176904241146!279;280$GO:0009617!response to bacterium!0.0460006060396343!3347;1755|id=C70|ontology_enrichment_celltype=|ontology_enrichment_disease=|ontology_enrichment_uberon=UBERON:0001829!9.38e-99!2;UBERON:0001044!2.58e-74!6;UBERON:0003293!2.58e-74!6;UBERON:0003294!2.58e-74!6;UBERON:0010047!2.58e-74!6;UBERON:0000167!2.58e-74!6;UBERON:0001831!1.46e-50!1;UBERON:0001567!1.46e-50!1;UBERON:0008801!1.46e-50!1;UBERON:0001736!3.99e-50!1;UBERON:0006298!3.99e-50!1;UBERON:0003408!4.18e-45!10;UBERON:0004089!4.32e-26!2;UBERON:0003127!9.18e-26!2;UBERON:0000166!3.99e-21!22;UBERON:0000165!2.82e-16!29;UBERON:0000930!2.82e-16!29;UBERON:0002365!2.73e-15!31;UBERON:0002330!2.73e-15!31;UBERON:0000161!2.66e-13!36;UBERON:0001004!1.50e-11!74;UBERON:0001444!5.14e-10!49;UBERON:0001041!5.98e-10!87;UBERON:0000464!3.52e-09!95;UBERON:0000033!7.15e-09!56;UBERON:0002530!1.83e-08!59;UBERON:0003126!2.35e-08!7;UBERON:0001005!2.35e-08!7;UBERON:0002553!3.25e-08!61;UBERON:0000153!4.28e-08!62;UBERON:0007811!4.28e-08!62;UBERON:0007023!8.86e-08!114;UBERON:0000466!1.34e-07!117;UBERON:0004921!1.75e-07!118|pathway_enrichment=7.11110300328319e-12;4.50132820107826e-09;7;89;Salivary secretion 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;0.319232,MA0052.1;0.887673,MA0055.1;8.62588e-07,MA0056.1;0,MA0057.1;4.75907e-05,MA0058.1;3.06252e-05,MA0059.1;0.0213941,MA0060.1;3.3911e-06,MA0061.1;2.94423,MA0063.1;0,MA0066.1;0.0100955,MA0067.1;0.0696676,MA0068.1;5.33499,MA0069.1;0.0333979,MA0070.1;0.55684,MA0071.1;2.1091,MA0072.1;0.0868257,MA0073.1;0,MA0074.1;0.00911637,MA0076.1;2.09143e-06,MA0077.1;2.16303,MA0078.1;1.17454,MA0081.1;0.002595,MA0083.1;0.0404563,MA0084.1;0.150801,MA0087.1;0.537119,MA0088.1;0.19554,MA0089.1;0,MA0090.1;0.504087,MA0091.1;0.0324931,MA0092.1;7.88231,MA0093.1;2.51424e-05,MA0095.1;0,MA0098.1;0,MA0100.1;1.97087e-05,MA0101.1;43.1954,MA0103.1;0.165286,MA0105.1;0.0536605,MA0106.1;0.00214334,MA0107.1;50.3,MA0108.2;0.544969,MA0109.1;0,MA0111.1;0.0350246,MA0113.1;1.69708,MA0114.1;0.00392976,MA0115.1;0.175851,MA0116.1;0.0399724,MA0117.1;0.0515061,MA0119.1;0.338725,MA0122.1;0.555929,MA0124.1;0.603823,MA0125.1;0.222739,MA0130.1;0,MA0131.1;0.609519,MA0132.1;0,MA0133.1;0,MA0135.1;0.728673,MA0136.1;0.16258,MA0139.1;57.2338,MA0140.1;0.0251802,MA0141.1;0.775407,MA0142.1;0.0457507,MA0143.1;4.69218,MA0144.1;85.8186,MA0145.1;9.05114e-08,MA0146.1;0,MA0147.1;1.91234e-08,MA0148.1;0.507931,MA0149.1;0.00345668,MA0062.2;1.17194e-05,MA0035.2;0.415928,MA0039.2;0,MA0138.2;0.00583914,MA0002.2;51.9867,MA0137.2;60.8286,MA0104.2;1.06077e-11,MA0047.2;0.129872,MA0112.2;0.0708573,MA0065.2;1.48176e-07,MA0150.1;0.205497,MA0151.1;0,MA0152.1;0.230049,MA0153.1;0.017542,MA0154.1;1.75474,MA0155.1;1.78405e-11,MA0156.1;3.15561,MA0157.1;0.0330905,MA0158.1;0,MA0159.1;0.00375723,MA0160.1;0.588348,MA0161.1;0,MA0162.1;4.27184,MA0163.1;0,MA0164.1;0.79391,MA0080.2;0.157554,MA0018.2;0.00220354,MA0099.2;0.0549739,MA0079.2;0,MA0102.2;0.509126,MA0258.1;3.0727,MA0259.1;3.65983e-08,MA0442.1;0}}
|full_id=C70_parotid_submaxillary_salivary_throat_trachea_aorta_tongue
|gostat_on_coexpression_clusters=GO:0016160!amylase activity!0.00022124418135433!279;280$GO:0004556!alpha-amylase activity!0.00022124418135433!279;280$GO:0030855!epithelial cell differentiation!0.0304966580906272!26298;1755$GO:0030670!phagocytic vesicle membrane!0.0334073818158868!1755$GO:0043152!induction of bacterial agglutination!0.0334073818158868!1755$GO:0031404!chloride ion binding!0.0334073818158868!279;280$GO:0043168!anion binding!0.0334073818158868!279;280$GO:0002009!morphogenesis of an epithelium!0.0334073818158868!26298;1755$GO:0019731!antibacterial humoral response!0.0334073818158868!1755$GO:0016889!endodeoxyribonuclease activity, producing 3'-phosphomonoesters!0.0334073818158868!58511$GO:0046676!negative regulation of insulin secretion!0.0334073818158868!131177$GO:0004531!deoxyribonuclease II activity!0.0334073818158868!58511$GO:0045335!phagocytic vesicle!0.0394176904241146!1755$GO:0019730!antimicrobial humoral response!0.0394176904241146!1755$GO:0042742!defense response to bacterium!0.0394176904241146!3347;1755$GO:0007586!digestion!0.0394176904241146!279;280$GO:0009617!response to bacterium!0.0460006060396343!3347;1755
|id=C70
}}

Latest revision as of 10:23, 17 September 2013


Full id: C70_parotid_submaxillary_salivary_throat_trachea_aorta_tongue



Phase1 CAGE Peaks

Hg19::chr10:124320156..124320170,+p2@DMBT1
Hg19::chr10:124320195..124320216,+p3@DMBT1
Hg19::chr10:5541512..5541523,-p2@CALML5
Hg19::chr10:5541525..5541539,-p1@CALML5
Hg19::chr10:55624430..55624435,-p@chr10:55624430..55624435
-
Hg19::chr10:99569253..99569259,+p@chr10:99569253..99569259
+
Hg19::chr11:111114722..111114730,+p@chr11:111114722..111114730
+
Hg19::chr11:114549168..114549178,+p2@FAM55B
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Hg19::chr12:11548496..11548505,-p10@PRB2
p1@PRB1
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Hg19::chr5:34043310..34043325,-p1@C1QTNF3
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Hg19::chr8:50037424..50037430,+p@chr8:50037424..50037430
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Hg19::chr8:63858336..63858340,+p@chr8:63858336..63858340
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Hg19::chr9:112970436..112970458,-p2@C9orf152
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Hg19::chr9:3971860..3971870,+p@chr9:3971860..3971870
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Hg19::chrX:129565220..129565223,+p@chrX:129565220..129565223
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Hg19::chrX:32229061..32229062,-p@chrX:32229061..32229062
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Hg19::chrX:53171146..53171174,-p@chrX:53171146..53171174
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Hg19::chrX:53171462..53171470,-p@chrX:53171462..53171470
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Hg19::chrX:98177758..98177763,+p@chrX:98177758..98177763
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

p.valueFDRnGenesnPathwayName
7.11110300328319e-124.50132820107826e-09789Salivary secretion (KEGG):04970



Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016160amylase activity0.00022124418135433
GO:0004556alpha-amylase activity0.00022124418135433
GO:0030855epithelial cell differentiation0.0304966580906272
GO:0030670phagocytic vesicle membrane0.0334073818158868
GO:0043152induction of bacterial agglutination0.0334073818158868
GO:0031404chloride ion binding0.0334073818158868
GO:0043168anion binding0.0334073818158868
GO:0002009morphogenesis of an epithelium0.0334073818158868
GO:0019731antibacterial humoral response0.0334073818158868
GO:0016889endodeoxyribonuclease activity, producing 3'-phosphomonoesters0.0334073818158868
GO:0046676negative regulation of insulin secretion0.0334073818158868
GO:0004531deoxyribonuclease II activity0.0334073818158868
GO:0045335phagocytic vesicle0.0394176904241146
GO:0019730antimicrobial humoral response0.0394176904241146
GO:0042742defense response to bacterium0.0394176904241146
GO:0007586digestion0.0394176904241146
GO:0009617response to bacterium0.0460006060396343



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
major salivary gland9.38e-992
saliva-secreting gland2.58e-746
gland of oral region2.58e-746
gland of foregut2.58e-746
oral gland2.58e-746
oral cavity2.58e-746
parotid gland1.46e-501
cheek1.46e-501
parotid gland primordium1.46e-501
submandibular gland3.99e-501
submandibular gland primordium3.99e-501
gland of gut4.18e-4510
midface4.32e-262
open tracheal system trachea9.18e-262
oral opening3.99e-2122
mouth2.82e-1629
stomodeum2.82e-1629
exocrine gland2.73e-1531
exocrine system2.73e-1531
orifice2.66e-1336
respiratory system1.50e-1174
subdivision of head5.14e-1049
foregut5.98e-1087
anatomical space3.52e-0995
head7.15e-0956
gland1.83e-0859
trachea2.35e-087
respiratory airway2.35e-087
anatomical cavity3.25e-0861
anterior region of body4.28e-0862
craniocervical region4.28e-0862
adult organism8.86e-08114
immaterial anatomical entity1.34e-07117
subdivision of digestive tract1.75e-07118


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10
MA0004.10.000913673
MA0006.11.16842e-06
MA0007.10.0389979
MA0009.10.230568
MA0014.10
MA0017.14.42295
MA0019.11.58293
MA0024.10.00209346
MA0025.10.0990638
MA0027.11.04659
MA0028.15.19365e-07
MA0029.10.399099
MA0030.10.115672
MA0031.10.0246636
MA0038.10.459144
MA0040.10.0573602
MA0041.14.3687
MA0042.13.04865
MA0043.10.00719461
MA0046.10.00640544
MA0048.17.4748e-09
MA0050.10.0439386
MA0051.10.319232
MA0052.10.887673
MA0055.18.62588e-07
MA0056.10
MA0057.14.75907e-05
MA0058.13.06252e-05
MA0059.10.0213941
MA0060.13.3911e-06
MA0061.12.94423
MA0063.10
MA0066.10.0100955
MA0067.10.0696676
MA0068.15.33499
MA0069.10.0333979
MA0070.10.55684
MA0071.12.1091
MA0072.10.0868257
MA0073.10
MA0074.10.00911637
MA0076.12.09143e-06
MA0077.12.16303
MA0078.11.17454
MA0081.10.002595
MA0083.10.0404563
MA0084.10.150801
MA0087.10.537119
MA0088.10.19554
MA0089.10
MA0090.10.504087
MA0091.10.0324931
MA0092.17.88231
MA0093.12.51424e-05
MA0095.10
MA0098.10
MA0100.11.97087e-05
MA0101.143.1954
MA0103.10.165286
MA0105.10.0536605
MA0106.10.00214334
MA0107.150.3
MA0108.20.544969
MA0109.10
MA0111.10.0350246
MA0113.11.69708
MA0114.10.00392976
MA0115.10.175851
MA0116.10.0399724
MA0117.10.0515061
MA0119.10.338725
MA0122.10.555929
MA0124.10.603823
MA0125.10.222739
MA0130.10
MA0131.10.609519
MA0132.10
MA0133.10
MA0135.10.728673
MA0136.10.16258
MA0139.157.2338
MA0140.10.0251802
MA0141.10.775407
MA0142.10.0457507
MA0143.14.69218
MA0144.185.8186
MA0145.19.05114e-08
MA0146.10
MA0147.11.91234e-08
MA0148.10.507931
MA0149.10.00345668
MA0062.21.17194e-05
MA0035.20.415928
MA0039.20
MA0138.20.00583914
MA0002.251.9867
MA0137.260.8286
MA0104.21.06077e-11
MA0047.20.129872
MA0112.20.0708573
MA0065.21.48176e-07
MA0150.10.205497
MA0151.10
MA0152.10.230049
MA0153.10.017542
MA0154.11.75474
MA0155.11.78405e-11
MA0156.13.15561
MA0157.10.0330905
MA0158.10
MA0159.10.00375723
MA0160.10.588348
MA0161.10
MA0162.14.27184
MA0163.10
MA0164.10.79391
MA0080.20.157554
MA0018.20.00220354
MA0099.20.0549739
MA0079.20
MA0102.20.509126
MA0258.13.0727
MA0259.13.65983e-08
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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