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Coexpression cluster:C3004: Difference between revisions

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|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0278160222279088
|tf_chipseq_enrich=CTCF#10664;3:5.36025637307503:0.006492509252767:0.0278160222279088
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}}
}}

Revision as of 15:52, 26 November 2012


Full id: C3004_smooth_putamen_bladder_vagina_neuroectodermal_caudate_salivary



Phase1 CAGE Peaks

Hg19::chr10:18429301..18429338,+p1@CACNB2
Hg19::chr10:18429342..18429359,+p3@CACNB2
Hg19::chr10:18429658..18429670,+p14@CACNB2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism2.50e-62114
neural tube2.20e-4256
neural rod2.20e-4256
future spinal cord2.20e-4256
neural keel2.20e-4256
regional part of nervous system1.67e-4053
regional part of brain1.67e-4053
central nervous system1.63e-3781
neurectoderm3.69e-3786
nervous system9.88e-3789
regional part of forebrain2.48e-3541
forebrain2.48e-3541
anterior neural tube2.48e-3541
future forebrain2.48e-3541
neural plate6.42e-3582
presumptive neural plate6.42e-3582
brain3.11e-3368
future brain3.11e-3368
telencephalon3.70e-3034
brain grey matter4.08e-3034
gray matter4.08e-3034
cerebral hemisphere3.21e-2932
regional part of telencephalon1.48e-2832
organ system subdivision1.39e-27223
ectoderm-derived structure4.54e-27171
ectoderm4.54e-27171
presumptive ectoderm4.54e-27171
pre-chordal neural plate8.78e-2761
structure with developmental contribution from neural crest4.56e-26132
ecto-epithelium2.83e-24104
cerebral cortex1.65e-2225
pallium1.65e-2225
regional part of cerebral cortex8.15e-2122
neocortex5.16e-1920
anatomical cluster2.09e-18373
multi-tissue structure1.76e-17342
multi-cellular organism1.18e-13656
embryo1.44e-11592
organ part4.45e-11218
organ1.95e-10503
anatomical conduit3.73e-10240
embryonic structure4.19e-10564
germ layer4.99e-10560
germ layer / neural crest4.99e-10560
embryonic tissue4.99e-10560
presumptive structure4.99e-10560
germ layer / neural crest derived structure4.99e-10560
epiblast (generic)4.99e-10560
developing anatomical structure7.72e-10581
basal ganglion3.68e-099
nuclear complex of neuraxis3.68e-099
aggregate regional part of brain3.68e-099
collection of basal ganglia3.68e-099
cerebral subcortex3.68e-099
neural nucleus5.31e-099
nucleus of brain5.31e-099
tube5.42e-09192
large intestine1.02e-0811
anatomical system1.59e-08624
posterior neural tube1.78e-0815
chordal neural plate1.78e-0815
epithelium1.83e-08306
anatomical group1.97e-08625
cell layer3.95e-08309
intestine1.02e-0717
temporal lobe1.16e-076
telencephalic nucleus1.68e-077
colon2.79e-079
segmental subdivision of hindbrain9.27e-0712
hindbrain9.27e-0712
presumptive hindbrain9.27e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066435.360256373075030.0064925092527670.0278160222279088



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.