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Coexpression cluster:C2418: Difference between revisions

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|tf_chipseq_enrich=CTCF#10664;4:5.36025637307503:0.00121114538164362:0.00816965785141628!CTCFL#140690;4:19.7464743589744:6.5732084880439e-06:0.000192836888000791!EP300#2033;4:6.7739417262232:0.000474845982144264:0.0043399351998919!STAT3#6774;4:10.5194649971542:8.16377768286615e-05:0.00123086008000701!TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0321999397810792!TCF7L2#6934;4:10.7701765631373:7.42969445082454e-05:0.00115365723870006!YY1#7528;4:4.91117074985386:0.0017187183805544:0.0106788761346137!ZBTB7A#51341;4:7.3519093078759:0.00034222354001599:0.00346365774742998
|tf_chipseq_enrich=CTCF#10664;4:5.36025637307503:0.00121114538164362:0.00816965785141628!CTCFL#140690;4:19.7464743589744:6.5732084880439e-06:0.000192836888000791!EP300#2033;4:6.7739417262232:0.000474845982144264:0.0043399351998919!STAT3#6774;4:10.5194649971542:8.16377768286615e-05:0.00123086008000701!TAF1#6872;4:3.34304628574529:0.00800566489870165:0.0321999397810792!TCF7L2#6934;4:10.7701765631373:7.42969445082454e-05:0.00115365723870006!YY1#7528;4:4.91117074985386:0.0017187183805544:0.0106788761346137!ZBTB7A#51341;4:7.3519093078759:0.00034222354001599:0.00346365774742998
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}}
}}

Revision as of 15:29, 26 November 2012


Full id: C2418_Renal_Urothelial_salivary_Corneal_Bronchial_Mammary_Keratinocyte



Phase1 CAGE Peaks

Hg19::chr17:48133330..48133349,+p2@ITGA3
Hg19::chr17:48133352..48133363,+p4@ITGA3
Hg19::chr17:48133424..48133443,+p3@ITGA3
Hg19::chr17:48133459..48133486,+p1@ITGA3


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell4.76e-39253
embryonic cell4.47e-33250
mesodermal cell3.69e-16121
squamous epithelial cell1.71e-1363
endo-epithelial cell2.10e-1242
kidney cell2.83e-1017
kidney epithelial cell2.83e-1017
animal cell8.57e-10679
eukaryotic cell8.57e-10679
epithelial cell of nephron1.38e-0915
endodermal cell2.49e-0958
mesothelial cell4.98e-0919
ecto-epithelial cell5.78e-0834
respiratory epithelial cell5.91e-0813
kidney tubule cell8.21e-0810
nephron tubule epithelial cell8.21e-0810
kidney cortical cell9.49e-0812
renal cortical epithelial cell9.49e-0812
lining cell1.03e-0758
barrier cell1.03e-0758
contractile cell1.22e-0759
non-terminally differentiated cell1.41e-07106
columnar/cuboidal epithelial cell2.34e-0727
muscle precursor cell4.30e-0758
myoblast4.30e-0758
multi-potent skeletal muscle stem cell4.30e-0758
ectodermal cell5.70e-0772
Uber Anatomy
Ontology termp-valuen
organism subdivision2.29e-19264
multi-tissue structure1.19e-15342
cell layer1.91e-15309
epithelium3.32e-15306
trunk2.24e-14199
anatomical system2.98e-12624
anatomical cluster3.51e-12373
anatomical group4.19e-12625
mesenchyme8.63e-12160
entire embryonic mesenchyme8.63e-12160
multi-cellular organism1.37e-11656
epithelial tube4.11e-11117
unilaminar epithelium6.57e-10148
nephron epithelium1.38e-0915
renal tubule1.38e-0915
nephron tubule1.38e-0915
nephron1.38e-0915
uriniferous tubule1.38e-0915
nephrogenic mesenchyme1.38e-0915
trunk mesenchyme1.92e-09122
epithelial vesicle2.06e-0978
multilaminar epithelium2.21e-0983
vasculature3.94e-0978
vascular system3.94e-0978
excretory tube4.11e-0916
kidney epithelium4.11e-0916
primordium6.92e-09160
trunk region element1.00e-08101
parenchyma1.22e-0815
surface structure3.31e-0899
endoderm-derived structure5.36e-08160
endoderm5.36e-08160
presumptive endoderm5.36e-08160
anatomical conduit6.00e-08240
cortex6.07e-0815
anatomical space7.08e-0895
nephron tubule epithelium8.21e-0810
cortex of kidney9.49e-0812
renal parenchyma9.49e-0812
ectodermal placode9.71e-0831
organ part1.18e-07218
embryo1.30e-07592
urinary system structure1.81e-0747
vessel2.88e-0768
renal system3.27e-0748
female organism3.84e-0741
somite4.21e-0771
presomitic mesoderm4.21e-0771
presumptive segmental plate4.21e-0771
dermomyotome4.21e-0771
trunk paraxial mesoderm4.21e-0771
developing anatomical structure5.37e-07581
paraxial mesoderm5.64e-0772
presumptive paraxial mesoderm5.64e-0772
immaterial anatomical entity5.68e-07117
dense mesenchyme tissue5.71e-0773
Disease
Ontology termp-valuen
reproductive organ cancer8.92e-0829
female reproductive organ cancer9.15e-0827


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00816965785141628
CTCFL#140690419.74647435897446.5732084880439e-060.000192836888000791
EP300#203346.77394172622320.0004748459821442640.0043399351998919
STAT3#6774410.51946499715428.16377768286615e-050.00123086008000701
TAF1#687243.343046285745290.008005664898701650.0321999397810792
TCF7L2#6934410.77017656313737.42969445082454e-050.00115365723870006
YY1#752844.911170749853860.00171871838055440.0106788761346137
ZBTB7A#5134147.35190930787590.000342223540015990.00346365774742998



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.