MCL coexpression mm9:2998

Phase1 CAGE Peaks

	Short description
Mm9::chr15:76028577..76028634,-	p4@Plec
Mm9::chr15:77672518..77672553,-	p1@Myh9
Mm9::chr15:77672563..77672584,-	p2@Myh9

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0032796	uropod organization and biogenesis	0.00205445680162165
GO:0051295	establishment of meiotic spindle localization	0.00205445680162165
GO:0051293	establishment of spindle localization	0.00205445680162165
GO:0051653	spindle localization	0.00205445680162165
GO:0007132	meiotic metaphase I	0.00205445680162165
GO:0043531	ADP binding	0.00205445680162165
GO:0001768	establishment of T cell polarity	0.00205445680162165
GO:0001767	establishment of lymphocyte polarity	0.00205445680162165
GO:0000212	meiotic spindle organization and biogenesis	0.00273927573549553
GO:0030898	actin-dependent ATPase activity	0.00316070277172562
GO:0031254	trailing edge	0.00316070277172562
GO:0000146	microfilament motor activity	0.00316070277172562
GO:0001931	uropod	0.00316070277172562
GO:0051323	metaphase	0.00338381120267096
GO:0014902	myotube differentiation	0.00338381120267096
GO:0000768	syncytium formation by plasma membrane fusion	0.00338381120267096
GO:0007520	myoblast fusion	0.00338381120267096
GO:0006949	syncytium formation	0.00365236764732738
GO:0031594	neuromuscular junction	0.00522952640412784
GO:0030010	establishment of cell polarity	0.00522952640412784
GO:0007051	spindle organization and biogenesis	0.00522952640412784
GO:0045026	plasma membrane fusion	0.00522952640412784
GO:0030048	actin filament-based movement	0.00535945252596953
GO:0030863	cortical cytoskeleton	0.00582096093792801
GO:0001725	stress fiber	0.0058320064046034
GO:0032432	actin filament bundle	0.0058320064046034
GO:0001772	immunological synapse	0.0058320064046034
GO:0048628	myoblast maturation	0.0058320064046034
GO:0051656	establishment of organelle localization	0.0058320064046034
GO:0006944	membrane fusion	0.0058320064046034
GO:0048627	myoblast development	0.0058320064046034
GO:0007163	establishment and/or maintenance of cell polarity	0.00597660160471753
GO:0051015	actin filament binding	0.00597660160471753
GO:0005913	cell-cell adherens junction	0.00621889626436825
GO:0051640	organelle localization	0.00621889626436825
GO:0007127	meiosis I	0.00621889626436825
GO:0044448	cell cortex part	0.00621889626436825
GO:0045445	myoblast differentiation	0.00778530998509257
GO:0005819	spindle	0.00800711368837157
GO:0022603	regulation of anatomical structure morphogenesis	0.00898227624895048
GO:0022604	regulation of cell morphogenesis	0.00898227624895048
GO:0005938	cell cortex	0.00898227624895048
GO:0008360	regulation of cell shape	0.00898227624895048
GO:0016459	myosin complex	0.0106458216084031
GO:0005912	adherens junction	0.0107334885962274
GO:0042692	muscle cell differentiation	0.0107334885962274
GO:0048741	skeletal muscle fiber development	0.0107334885962274
GO:0000226	microtubule cytoskeleton organization and biogenesis	0.0107334885962274
GO:0048747	muscle fiber development	0.0107334885962274
GO:0051327	M phase of meiotic cell cycle	0.0114739474203775
GO:0007126	meiosis	0.0114739474203775
GO:0048469	cell maturation	0.0114739474203775
GO:0051321	meiotic cell cycle	0.0114739474203775
GO:0021700	developmental maturation	0.013848560662783
GO:0007519	skeletal muscle development	0.0141944288112041
GO:0030705	cytoskeleton-dependent intracellular transport	0.0143811976113516
GO:0005516	calmodulin binding	0.0154264475630538
GO:0042110	T cell activation	0.0165749396198628
GO:0001701	in utero embryonic development	0.0165749396198628
GO:0014706	striated muscle development	0.0167095819865228
GO:0005911	intercellular junction	0.0202077718192294
GO:0030029	actin filament-based process	0.0216533224805838
GO:0007517	muscle development	0.0216533224805838
GO:0007017	microtubule-based process	0.0225990248178382
GO:0000904	cellular morphogenesis during differentiation	0.0233042861079471
GO:0046649	lymphocyte activation	0.0233042861079471
GO:0015629	actin cytoskeleton	0.0233042861079471
GO:0045321	leukocyte activation	0.0247725805644814
GO:0016337	cell-cell adhesion	0.0247725805644814
GO:0001775	cell activation	0.0253289194720478
GO:0043009	chordate embryonic development	0.0253289194720478
GO:0009792	embryonic development ending in birth or egg hatching	0.0253289194720478
GO:0042623	ATPase activity, coupled	0.0253289194720478
GO:0000279	M phase	0.0255300498548184
GO:0016044	membrane organization and biogenesis	0.0255300498548184
GO:0003779	actin binding	0.0261672918943389
GO:0050793	regulation of developmental process	0.0270586993384315
GO:0016887	ATPase activity	0.0270586993384315
GO:0032990	cell part morphogenesis	0.0270586993384315
GO:0048858	cell projection morphogenesis	0.0270586993384315
GO:0030030	cell projection organization and biogenesis	0.0270586993384315
GO:0022403	cell cycle phase	0.0270586993384315
GO:0015630	microtubule cytoskeleton	0.0283168503741587
GO:0006928	cell motility	0.0313244237047254
GO:0051674	localization of cell	0.0313244237047254
GO:0008092	cytoskeletal protein binding	0.0319157475228666
GO:0042995	cell projection	0.0343826333696681
GO:0030054	cell junction	0.0357662252282315
GO:0017111	nucleoside-triphosphatase activity	0.04036668968461
GO:0009790	embryonic development	0.04036668968461
GO:0007010	cytoskeleton organization and biogenesis	0.04036668968461
GO:0000902	cell morphogenesis	0.0404899194652934
GO:0032989	cellular structure morphogenesis	0.0404899194652934
GO:0016462	pyrophosphatase activity	0.0404899194652934
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0404899194652934
GO:0016817	hydrolase activity, acting on acid anhydrides	0.0404899194652934
GO:0044430	cytoskeletal part	0.0440543314162169
GO:0022402	cell cycle process	0.0462881695712307
GO:0046907	intracellular transport	0.0471487459927717
GO:0022610	biological adhesion	0.0478423999743973
GO:0007155	cell adhesion	0.0478423999743973

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
multi-potent skeletal muscle stem cell	5.26e-07	9

Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	1.10e-10	118
endoderm	1.10e-10	118
presumptive endoderm	1.10e-10	118
digestive system	6.34e-10	116
digestive tract	6.34e-10	116
primitive gut	6.34e-10	116
subdivision of digestive tract	6.53e-10	114
mixed endoderm/mesoderm-derived structure	4.91e-09	35
respiratory tract	8.66e-09	41
respiratory system	1.18e-08	42
foregut	8.14e-08	80
hemolymphoid system	1.53e-07	48
immune system	1.53e-07	48
hematopoietic system	2.33e-07	45
blood island	2.33e-07	45
hemopoietic organ	4.95e-07	29
immune organ	4.95e-07	29
skeletal muscle tissue	5.26e-07	9
striated muscle tissue	5.26e-07	9
muscle tissue	5.26e-07	9
multilaminar epithelium	5.26e-07	9
epithelial vesicle	5.26e-07	9
musculature	5.26e-07	9
somite	5.26e-07	9
myotome	5.26e-07	9
presomitic mesoderm	5.26e-07	9
presumptive segmental plate	5.26e-07	9
dermomyotome	5.26e-07	9
trunk paraxial mesoderm	5.26e-07	9

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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