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Revision as of 17:15, 15 June 2012

Name:liver
Definition:"An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]." [BTO:0000759, Wikipedia:Liver]
Xrefs:
links:

AAO:0010111
BTO:0000759
EFO:0000887
EHDAA:2197
EHDAA2:0000997
EMAPA:16846
EV:0100089
FMA:7197
GAID:288
galen:Liver
[1]
MA:0000358
MAT:0000097
MESH:A.03.620
MIAA:0000097
ncithesaurus:Liver
OpenCyc:Mx4rvVimppwpEbGdrcN5Y29ycA
SCTID:181268008
TAO:0000123
VHOG:0000257
XAO:0000133

ZFA:0000123
Comments:Only ZFA considers this part_of immune system. WP: The liver is found in all vertebrates, and is typically the largest visceral organ. Its form varies considerably in different species, and is largely determined by the shape and arrangement of the surrounding organs. Nonetheless, in most species it is divided into right and left lobes; exceptions to this general rule include snakes, where the shape of the body necessitates a simple cigar-like form. The internal structure of the liver is broadly similar in all vertebrates.[7] An organ sometimes referred to as a liver is found associated with the digestive tract of the primitive chordate Amphioxus. However, this is an enzyme secreting gland, not a metabolic organ, and it is unclear how truly homologous it is to the vertebrate liver.
Alt_id: UBERON:FMA_7197-MA_0000358-MIAA_0000097-XAO_0000133-ZFA_0000123
Subset: major_organ
organ_slim
uberon_slim
vertebrate_core

Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data

Parents

is_a:UBERON:0000077(mixed endoderm/mesoderm-derived structure),UBERON:0002365(exocrine gland),UBERON:0005057(immune organ),UBERON:0005172(abdomen element),UBERON:0006925(digestive gland)
develops_from:UBERON:0003894(liver primordium),UBERON:0004161(septum transversum),UBERON:0008836(liver bud)
part_of:UBERON:0000916(abdomen),UBERON:0000949(endocrine system),UBERON:0001007(digestive system),UBERON:0002405(immune system),UBERON:0002423(hepatobiliary system)



Children

derives from:FF:0010018 (human liver - adult sample),FF:0010086 (human liver - fetal sample),FF:0011320 (mouse liver- embryo E12 sample),FF:0011328 (mouse liver- embryo E13 sample),FF:0011340 (mouse liver- embryo E14 sample),FF:0011349 (mouse liver- embryo E15 sample),FF:0011361 (mouse liver- embryo E16 sample),FF:0011369 (mouse liver- embryo E17 sample),FF:0011376 (mouse liver- embryo E18 sample),FF:0011379 (mouse liver- adult pregnant day01 sample),FF:0011395 (mouse liver- neonate N00 sample),FF:0011403 (mouse liver- neonate N06 sample),FF:0011409 (mouse liver- neonate N07 sample),FF:0011416 (mouse liver- neonate N10 sample),FF:0011429 (mouse liver- neonate N20 sample),FF:0011484 (mouse liver- neonate N03 sample),FF:0011485 (mouse liver- neonate N25 sample),FF:0011486 (mouse liver- neonate N30 sample),FF:0100224 (liver cell line sample)
part of:CL:0000182 (hepatocyte),CL:0000632 (hepatic stellate cell),UBERON:0001280 (liver parenchyma),UBERON:0001281 (hepatic sinusoid),CL:0002195 (hepatic stem cell),CL:0002571 (hepatic mesenchymal stem cell),UBERON:0003704 (intrahepatic bile duct),UBERON:0006877 (vasculature of liver),UBERON:0015796 (liver blood vessel)

Ontology Tree: Loaded from BioPortal

Ontorolgy tree(Small window open)

FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology

Human (Homo sapiens)

... further results Mouse (Mus musculus)

... further results


Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0002107 (liver), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data

P-valueFFCPShort description
3.93e-83FFCP PHASE2:Hg19::chr12:100867777..100867788,+#_d23f8b9a7a7fa496066ab77ee2f7eaa2p5@NR1H4
3.93e-83FFCP PHASE1:Hg19::chr12:100867777..100867788,+#_d23f8b9a7a7fa496066ab77ee2f7eaa2p5@NR1H4
1.46e-82FFCP PHASE1:Hg19::chr8:144417558..144417572,-#_820e70d67b222ca2e5c6c419e4e0f4ccp7@TOP1MT
1.46e-82FFCP PHASE1:Hg19::chr2:21233797..21233804,-#_820e70d67b222ca2e5c6c419e4e0f4ccp58@APOB
1.46e-82FFCP PHASE2:Hg19::chr2:21233797..21233804,-#_820e70d67b222ca2e5c6c419e4e0f4ccp58@APOB
1.46e-82FFCP PHASE2:Hg19::chr8:144417558..144417572,-#_820e70d67b222ca2e5c6c419e4e0f4ccp7@TOP1MT
5.75e-76FFCP PHASE2:Hg19::chrX:153769426..153769436,+#_8b260d0a09e3f2a5a56a640a1c773a67p18@IKBKG
5.75e-76FFCP PHASE1:Hg19::chrX:153769426..153769436,+#_8b260d0a09e3f2a5a56a640a1c773a67p18@IKBKG
9.69e-76FFCP PHASE1:Hg19::chr10:7745167..7745178,+#_fbadd152fd9675cef01f72d0c072597ap3@ITIH2
9.69e-76FFCP PHASE2:Hg19::chr10:7745167..7745178,+#_fbadd152fd9675cef01f72d0c072597ap3@ITIH2
1.94e-75FFCP PHASE2:Hg19::chr2:97216132..97216143,+#_500b02183908449299436f1b80831ed4p@chr2:97216132..97216143, +
1.94e-75FFCP PHASE1:Hg19::chr2:97216132..97216143,+#_500b02183908449299436f1b80831ed4p@chr2:97216132..97216143, +
1.74e-73FFCP PHASE1:Hg19::chr20:10349456..10349475,-#_f9f0d93bb84ba861f1b3d3787127c201p1@ENST00000421143
1.74e-73FFCP PHASE2:Hg19::chr2:21239379..21239390,-#_f9f0d93bb84ba861f1b3d3787127c201p@chr2:21239379..21239390, -
1.74e-73FFCP PHASE1:Hg19::chr10:82049381..82049384,-#_f9f0d93bb84ba861f1b3d3787127c201p9@MAT1A
1.74e-73FFCP PHASE2:Hg19::chr2:21258509..21258518,-#_f9f0d93bb84ba861f1b3d3787127c201p@chr2:21258509..21258518, -
1.74e-73FFCP PHASE2:Hg19::chr2:21228233..21228242,-#_f9f0d93bb84ba861f1b3d3787127c201p56@APOB
1.74e-73FFCP PHASE1:Hg19::chr2:21258509..21258518,-#_f9f0d93bb84ba861f1b3d3787127c201p@chr2:21258509..21258518, -
1.74e-73FFCP PHASE1:Hg19::chr2:21228233..21228242,-#_f9f0d93bb84ba861f1b3d3787127c201p56@APOB
1.74e-73FFCP PHASE2:Hg19::chr20:10349456..10349475,-#_f9f0d93bb84ba861f1b3d3787127c201p1@ENST00000421143
1.74e-73FFCP PHASE2:Hg19::chr20:22566089..22566097,-#_f9f0d93bb84ba861f1b3d3787127c201p6@FOXA2
1.74e-73FFCP PHASE1:Hg19::chr2:21239379..21239390,-#_f9f0d93bb84ba861f1b3d3787127c201p@chr2:21239379..21239390, -
1.74e-73FFCP PHASE2:Hg19::chr10:82049381..82049384,-#_f9f0d93bb84ba861f1b3d3787127c201p9@MAT1A
1.74e-73FFCP PHASE1:Hg19::chr20:22566089..22566097,-#_f9f0d93bb84ba861f1b3d3787127c201p6@FOXA2
2.11e-73FFCP PHASE2:Hg19::chr1:230846000..230846009,-#_5cdf544678ddc8e12f47e026ad59a679p@chr1:230846000..230846009, -
2.11e-73FFCP PHASE1:Hg19::chr14:94844853..94844862,-#_5cdf544678ddc8e12f47e026ad59a679p35@SERPINA1
2.11e-73FFCP PHASE2:Hg19::chr14:94844853..94844862,-#_5cdf544678ddc8e12f47e026ad59a679p35@SERPINA1
2.11e-73FFCP PHASE1:Hg19::chr1:230846000..230846009,-#_5cdf544678ddc8e12f47e026ad59a679p@chr1:230846000..230846009, -
1.22e-72FFCP PHASE2:Mm9::chr5:90897694..90897705,+#_565549a1af54e13e94a0e201aea4352bp@chr5:90897694..90897705, +
1.22e-72FFCP PHASE1:Mm9::chr5:90897694..90897705,+#_565549a1af54e13e94a0e201aea4352bp@chr5:90897694..90897705, +
1.97e-72FFCP PHASE2:Hg19::chr2:21256369..21256378,-#_4333af4ef5bec69e8628066b0a707a19p@chr2:21256369..21256378, -
1.97e-72FFCP PHASE1:Hg19::chr2:21232865..21232870,-#_4333af4ef5bec69e8628066b0a707a19p10@BC172787
1.97e-72FFCP PHASE1:Hg19::chr2:21256369..21256378,-#_4333af4ef5bec69e8628066b0a707a19p@chr2:21256369..21256378, -
1.97e-72FFCP PHASE1:Hg19::chr10:7763609..7763619,+#_4333af4ef5bec69e8628066b0a707a19p@chr10:7763609..7763619, +
1.97e-72FFCP PHASE1:Hg19::chr2:44066386..44066398,-#_4333af4ef5bec69e8628066b0a707a19p6@ABCG5
1.97e-72FFCP PHASE2:Hg19::chr10:7763609..7763619,+#_4333af4ef5bec69e8628066b0a707a19p@chr10:7763609..7763619, +
1.97e-72FFCP PHASE1:Hg19::chr12:57828432..57828442,+#_4333af4ef5bec69e8628066b0a707a19p7@INHBC
1.97e-72FFCP PHASE2:Hg19::chr2:21230675..21230682,-#_4333af4ef5bec69e8628066b0a707a19p51@APOB
1.97e-72FFCP PHASE1:Hg19::chr2:21234502..21234510,-#_4333af4ef5bec69e8628066b0a707a19p43@APOB
1.97e-72FFCP PHASE2:Hg19::chr2:21232865..21232870,-#_4333af4ef5bec69e8628066b0a707a19p10@BC172787
1.97e-72FFCP PHASE2:Hg19::chr2:21234502..21234510,-#_4333af4ef5bec69e8628066b0a707a19p43@APOB
1.97e-72FFCP PHASE2:Hg19::chr2:20793103..20793113,-#_4333af4ef5bec69e8628066b0a707a19p@chr2:20793103..20793113, -
1.97e-72FFCP PHASE2:Hg19::chr17:7082861..7082882,-#_4333af4ef5bec69e8628066b0a707a19p9@ASGR1
1.97e-72FFCP PHASE2:Hg19::chr12:57828432..57828442,+#_4333af4ef5bec69e8628066b0a707a19p7@INHBC
1.97e-72FFCP PHASE1:Hg19::chr2:20793103..20793113,-#_4333af4ef5bec69e8628066b0a707a19p@chr2:20793103..20793113, -
1.97e-72FFCP PHASE1:Hg19::chr17:7082861..7082882,-#_4333af4ef5bec69e8628066b0a707a19p9@ASGR1
1.97e-72FFCP PHASE1:Hg19::chr2:21231676..21231681,-#_4333af4ef5bec69e8628066b0a707a19p75@APOB
1.97e-72FFCP PHASE1:Hg19::chr2:21230675..21230682,-#_4333af4ef5bec69e8628066b0a707a19p51@APOB
1.97e-72FFCP PHASE2:Hg19::chr2:44066386..44066398,-#_4333af4ef5bec69e8628066b0a707a19p6@ABCG5
1.97e-72FFCP PHASE2:Hg19::chr2:21231676..21231681,-#_4333af4ef5bec69e8628066b0a707a19p75@APOB
2.2e-72FFCP PHASE1:Mm9::chr19:25169885..25169900,+#_c2d617a45ba2d7071a2463b464b49e57p@chr19:25169885..25169900, +
2.2e-72FFCP PHASE2:Mm9::chr19:25169885..25169900,+#_c2d617a45ba2d7071a2463b464b49e57p@chr19:25169885..25169900, +
5.51e-71FFCP PHASE1:Mm9::chr7:121912281..121912295,+#_de7762314134dc18c1a4b343c879bc20p6@Insc
5.51e-71FFCP PHASE2:Mm9::chr7:121912281..121912295,+#_de7762314134dc18c1a4b343c879bc20p6@Insc
1.05e-70FFCP PHASE2:Hg19::chr12:100867695..100867706,+#_94921d8a33827bc3b39a7dc4bc6132dap6@NR1H4
1.05e-70FFCP PHASE1:Hg19::chr12:100867695..100867706,+#_94921d8a33827bc3b39a7dc4bc6132dap6@NR1H4
1.7e-70FFCP PHASE1:Mm9::chr8:131012371..131012382,-#_6f8686f7a6eab1e2b12e797c6370ac00p2@uc009nzu.1
1.7e-70FFCP PHASE2:Mm9::chr8:131012371..131012382,-#_6f8686f7a6eab1e2b12e797c6370ac00p2@uc009nzu.1
8.65e-70FFCP PHASE1:Hg19::chr17:7082560..7082572,-#_b58309d53618b2c18e19c2f7d1e28eedp4@ASGR1
8.65e-70FFCP PHASE2:Hg19::chr17:7082560..7082572,-#_b58309d53618b2c18e19c2f7d1e28eedp4@ASGR1
1.02e-69FFCP PHASE2:Hg19::chr10:72083665..72083701,-#_3d720e4866b53bded86b24a6851bdfefp2@LRRC20
1.02e-69FFCP PHASE1:Hg19::chr10:72083665..72083701,-#_3d720e4866b53bded86b24a6851bdfefp2@LRRC20
1.64e-69FFCP PHASE2:Hg19::chr1:11107289..11107304,-#_b8329beff6e9adf606f6fe8855e32d53p1@MASP2
1.64e-69FFCP PHASE2:Hg19::chr9:116838918..116838930,-#_b8329beff6e9adf606f6fe8855e32d53p@chr9:116838918..116838930, -
1.64e-69FFCP PHASE1:Hg19::chr9:116838918..116838930,-#_b8329beff6e9adf606f6fe8855e32d53p@chr9:116838918..116838930, -
1.64e-69FFCP PHASE1:Hg19::chr1:11107289..11107304,-#_b8329beff6e9adf606f6fe8855e32d53p1@MASP2
2.08e-69FFCP PHASE1:Hg19::chr3:197300199..197300219,-#_82bc304d773def4212e36234058ef628p2@BDH1
2.08e-69FFCP PHASE2:Hg19::chr3:197300199..197300219,-#_82bc304d773def4212e36234058ef628p2@BDH1
2.25e-69FFCP PHASE2:Hg19::chr4:155528001..155528060,-#_9d96dfd9e226208cbb11bb2ff74842edp@chr4:155528001..155528060, -
2.25e-69FFCP PHASE2:Hg19::chr19:45430057..45430062,+#_9d96dfd9e226208cbb11bb2ff74842edp1@APOC1P1
2.25e-69FFCP PHASE1:Hg19::chr9:116838988..116838999,-#_9d96dfd9e226208cbb11bb2ff74842edp@chr9:116838988..116838999, -
2.25e-69FFCP PHASE2:Hg19::chr9:116838988..116838999,-#_9d96dfd9e226208cbb11bb2ff74842edp@chr9:116838988..116838999, -
2.25e-69FFCP PHASE1:Hg19::chr4:155528001..155528060,-#_9d96dfd9e226208cbb11bb2ff74842edp@chr4:155528001..155528060, -
2.25e-69FFCP PHASE1:Hg19::chr19:45430057..45430062,+#_9d96dfd9e226208cbb11bb2ff74842edp1@APOC1P1
2.64e-69FFCP PHASE2:Hg19::chr17:7017634..7017649,-#_8c2be9342882878c94e62c405896e73fp7@ASGR2
2.64e-69FFCP PHASE1:Hg19::chr17:7017634..7017649,-#_8c2be9342882878c94e62c405896e73fp7@ASGR2
2.64e-69FFCP PHASE1:Hg19::chr11:116662593..116662620,-#_8c2be9342882878c94e62c405896e73fp1@APOA5
2.64e-69FFCP PHASE2:Hg19::chr11:116662593..116662620,-#_8c2be9342882878c94e62c405896e73fp1@APOA5
1.28e-68FFCP PHASE2:Mm9::chr13:94407586..94407604,-#_b978123e099b6fbd3786a886d768a653p5@Bhmt
1.28e-68FFCP PHASE1:Mm9::chr13:94407586..94407604,-#_b978123e099b6fbd3786a886d768a653p5@Bhmt
2.72e-68FFCP PHASE2:Mm9::chr1:162917234..162917248,+#_91bb96e93653bb7a10680f38a36f2fb3p@chr1:162917234..162917248, +
2.72e-68FFCP PHASE1:Mm9::chr1:162917234..162917248,+#_91bb96e93653bb7a10680f38a36f2fb3p@chr1:162917234..162917248, +
3.5e-68FFCP PHASE2:Mm9::chr9:110892216..110892232,-#_62d7fd9a88d2e0adb17ae4e355b468b0p1@Rtp3
3.5e-68FFCP PHASE1:Mm9::chr9:110892216..110892232,-#_62d7fd9a88d2e0adb17ae4e355b468b0p1@Rtp3
2.47e-67FFCP PHASE2:Mm9::chr9:110892239..110892252,-#_6ac68a5ff2955cba481f45fd8664c6dbp2@Rtp3
2.47e-67FFCP PHASE2:Mm9::chr7:112744083..112744109,-#_6ac68a5ff2955cba481f45fd8664c6dbp@chr7:112744083..112744109, -
2.47e-67FFCP PHASE1:Mm9::chr7:112744083..112744109,-#_6ac68a5ff2955cba481f45fd8664c6dbp@chr7:112744083..112744109, -
2.47e-67FFCP PHASE1:Mm9::chr9:110892239..110892252,-#_6ac68a5ff2955cba481f45fd8664c6dbp2@Rtp3
6.55e-67FFCP PHASE2:Mm9::chr13:23928766..23928779,+#_4b3a9f9dbad3c4262694112a89ffce45p@chr13:23928766..23928779, +
6.55e-67FFCP PHASE1:Mm9::chr13:23928766..23928779,+#_4b3a9f9dbad3c4262694112a89ffce45p@chr13:23928766..23928779, +
7.85e-67FFCP PHASE2:Mm9::chr7:28237436..28237488,+#_81dc07a7d10185efce398654f09850e4p3@Blvrb
7.85e-67FFCP PHASE1:Mm9::chr7:28237436..28237488,+#_81dc07a7d10185efce398654f09850e4p3@Blvrb
1.58e-66FFCP PHASE2:Mm9::chr12:105004018..105004046,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr12:105004018..105004046, -
1.58e-66FFCP PHASE1:Mm9::chr12:105004018..105004046,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr12:105004018..105004046, -
1.58e-66FFCP PHASE1:Mm9::chr2:10041210..10041222,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr2:10041210..10041222, -
1.58e-66FFCP PHASE1:Mm9::chr16:22894900..22894910,+#_89ca54c41602cbe2f12290a07b4cbb2fp@chr16:22894900..22894910, +
1.58e-66FFCP PHASE2:Mm9::chr2:10041210..10041222,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr2:10041210..10041222, -
1.58e-66FFCP PHASE2:Mm9::chr6:128436166..128436185,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr6:128436166..128436185, -
1.58e-66FFCP PHASE1:Mm9::chr16:22898981..22898988,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr16:22898981..22898988, -
1.58e-66FFCP PHASE2:Mm9::chr16:22898981..22898988,-#_89ca54c41602cbe2f12290a07b4cbb2fp@chr16:22898981..22898988, -

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