CL:0000632
From FANTOM5_SSTAR
| Name: | hepatic stellate cell | ||
|---|---|---|---|
| Namespace: | FANTOM | ||
| Definition: | "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:dsd, MESH:D055166, PMID:12808230, PMID:17239632, PMID:18222966, PMID:9302568] | ||
| Xrefs: |
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| Synonyms: |
"fat-storing cell" RELATED [] "hepatic perisinusoidal cell" EXACT [] "ito cell" EXACT [] "lipocyte" RELATED [] "perisinusoidal cell" EXACT [] "vitamin A-storing cells" RELATED [PMID:12808230] | ||
| Comments: | Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen. |
Ontology association <br>Each term has an is_a parent in the Cell ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to Cell ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | CL:0000057(fibroblast),CL:0000327(extracellular matrix secreting cell) |
|---|---|
| part_of: | UBERON:0002107(liver) |
Children
| is a: | FF:13610-146G1 (hepatic stellate cells, sham operation, biol_rep1),FF:13611-146G2 (hepatic stellate cells, sham operation, biol_rep2),FF:13612-146G3 (hepatic stellate cells, sham operation, biol_rep3),FF:13613-146G4 (hepatic stellate cells, partial hepatectomy, 02hr, biol_rep1),FF:13616-146G7 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep1),FF:13617-146G8 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep2),FF:13618-146G9 (hepatic stellate cells, partial hepatectomy, 30hr, biol_rep3),FF:13619-146H1 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep1),FF:13620-146H2 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep2),FF:13621-146H3 (hepatic stellate cells, partial hepatectomy, 48hr, biol_rep3),FF:13622-146H4 (hepatic stellate cells, partial hepatectomy, week01, biol_rep1) |
|---|---|
| derives from: | FF:0000077 (hepatic stellate cell sample),FF:0103513 (hepatic stellate cell line sample) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Cell ontology.
Human (Homo sapiens)
- 10778-110G4 (hepatic mesenchymal tumor cell line:LI90)
- 11524-119I3 (Hepatic Stellate Cells (lipocyte), donor1)
- 11604-120I2 (Hepatic Stellate Cells (lipocyte), donor2)
- 11685-122I2 (Hepatic Stellate Cells (lipocyte), donor3)
- 11825-124F7 (Mouse hepatic Stellate Cells (lipocyte), donor1)
- 11826-124F8
- 11827-124F9
- 11828-124G1
- 11829-124G2
- 13610-146G1 (hepatic stellate cells, sham operation, biol_rep1)
... further results Mouse (Mus musculus)
- 10778-110G4 (hepatic mesenchymal tumor cell line:LI90)
- 11524-119I3 (Hepatic Stellate Cells (lipocyte), donor1)
- 11604-120I2 (Hepatic Stellate Cells (lipocyte), donor2)
- 11685-122I2 (Hepatic Stellate Cells (lipocyte), donor3)
- 11825-124F7 (Mouse hepatic Stellate Cells (lipocyte), donor1)
- 11826-124F8
- 11827-124F9
- 11828-124G1
- 11829-124G2
- 13610-146G1 (hepatic stellate cells, sham operation, biol_rep1)
Enrichment analysis: top 100 FFCP enriched with this ontology termTOP 100 FANTOM5 Cage Peaks enriched with CL:0000632 (hepatic stellate cell), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
| P-value | FFCP | Short description |
|---|---|---|
| 3.07e-86 | FFCP PHASE1:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7b | p@chr10:94173889..94173890, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7b | p1@Mup20 |
| 3.07e-86 | FFCP PHASE2:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr4:50498164..50498166, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr4:61715146..61715151,-#_a63e837d7ad731b842007587a1e8ae7b | p1@Mup20 |
| 3.07e-86 | FFCP PHASE2:Mm9::chr10:94173889..94173890,-#_a63e837d7ad731b842007587a1e8ae7b | p@chr10:94173889..94173890, - |
| 3.07e-86 | FFCP PHASE1:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7b | p@chrX:45409736..45409738, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr17:15914532..15914535, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr2:156282978..156282979, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chrX:45409736..45409738,+#_a63e837d7ad731b842007587a1e8ae7b | p@chrX:45409736..45409738, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr17:15914532..15914535,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr17:15914532..15914535, + |
| 3.07e-86 | FFCP PHASE1:Mm9::chr4:50498164..50498166,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr4:50498164..50498166, + |
| 3.07e-86 | FFCP PHASE2:Mm9::chr2:156282978..156282979,+#_a63e837d7ad731b842007587a1e8ae7b | p@chr2:156282978..156282979, + |
| 2.19e-53 | FFCP PHASE1:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160d | p75@IGFBP5 |
| 2.19e-53 | FFCP PHASE2:Hg19::chr2:217538399..217538408,-#_9a0afcf9d50bdd0443f926c38d5f160d | p75@IGFBP5 |
| 7.47e-44 | FFCP PHASE2:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302f | p@chr5:114824802..114824807, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:111614187..111614200, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302f | p@chr8:42092122..42092137, - |
| 7.47e-44 | FFCP PHASE1:Mm9::chr5:114824802..114824807,+#_99984e512eb12ee2db273a1e122f302f | p@chr5:114824802..114824807, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302f | p@chr18:38702532..38702560, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302f | p@chr11:48686060..48686062, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302f | p@chr3:127483562..127483571, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr7:111614187..111614200,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:111614187..111614200, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr11:48686060..48686062,+#_99984e512eb12ee2db273a1e122f302f | p@chr11:48686060..48686062, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr18:38702532..38702560,+#_99984e512eb12ee2db273a1e122f302f | p@chr18:38702532..38702560, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302f | p@chrX:166354085..166354088, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302f | p@chr6:31268117..31268151, - |
| 7.47e-44 | FFCP PHASE1:Mm9::chr3:127483562..127483571,+#_99984e512eb12ee2db273a1e122f302f | p@chr3:127483562..127483571, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:129965112..129965151, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr7:129965112..129965151,+#_99984e512eb12ee2db273a1e122f302f | p@chr7:129965112..129965151, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302f | p7@Rbm18 |
| 7.47e-44 | FFCP PHASE2:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302f | p@chr19:39390004..39390011, + |
| 7.47e-44 | FFCP PHASE1:Mm9::chr2:35991779..35991800,-#_99984e512eb12ee2db273a1e122f302f | p7@Rbm18 |
| 7.47e-44 | FFCP PHASE2:Mm9::chrX:166354085..166354088,+#_99984e512eb12ee2db273a1e122f302f | p@chrX:166354085..166354088, + |
| 7.47e-44 | FFCP PHASE2:Mm9::chr6:31268117..31268151,-#_99984e512eb12ee2db273a1e122f302f | p@chr6:31268117..31268151, - |
| 7.47e-44 | FFCP PHASE2:Mm9::chr8:42092122..42092137,-#_99984e512eb12ee2db273a1e122f302f | p@chr8:42092122..42092137, - |
| 7.47e-44 | FFCP PHASE1:Mm9::chr19:39390004..39390011,+#_99984e512eb12ee2db273a1e122f302f | p@chr19:39390004..39390011, + |
| 3.19e-38 | FFCP PHASE1:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709 | p@chr1:153091885..153091892, - |
| 3.19e-38 | FFCP PHASE2:Hg19::chr1:153091885..153091892,-#_43cb5a698f1e5cf9b1724411e050f709 | p@chr1:153091885..153091892, - |
| 4.27e-34 | FFCP PHASE2:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3eb | p10@WT1-AS |
| 4.27e-34 | FFCP PHASE1:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3eb | p15@DAK |
| 4.27e-34 | FFCP PHASE1:Hg19::chr11:32457367..32457372,+#_e3687bef5f55adb27e5177e93ccfe3eb | p10@WT1-AS |
| 4.27e-34 | FFCP PHASE2:Hg19::chr11:61112998..61113003,+#_e3687bef5f55adb27e5177e93ccfe3eb | p15@DAK |
| 4.66e-34 | FFCP PHASE2:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125 | p10@LRRN4 |
| 4.66e-34 | FFCP PHASE1:Hg19::chr20:6034557..6034560,-#_c020e97ed8ca72528d8bf56dd471b125 | p10@LRRN4 |
| 5.96e-34 | FFCP PHASE1:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853 | p2@AK123249 |
| 5.96e-34 | FFCP PHASE2:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853 | p@chr9:21499446..21499456, - |
| 5.96e-34 | FFCP PHASE2:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853 | p@chr4:37636545..37636557, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853 | p1@AB527600 |
| 5.96e-34 | FFCP PHASE1:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853 | p@chr16:46766272..46766280, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853 | p@chr13:38275506..38275512, - |
| 5.96e-34 | FFCP PHASE2:Hg19::chr12:123356789..123356800,-#_48522f89037c59d8e980cd0dea55f853 | p2@AK123249 |
| 5.96e-34 | FFCP PHASE2:Hg19::chr13:38275506..38275512,-#_48522f89037c59d8e980cd0dea55f853 | p@chr13:38275506..38275512, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853 | p@chr17:10560452..10560487, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853 | p@chr6:3759217..3759221, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr20:2820409..2820435,-#_48522f89037c59d8e980cd0dea55f853 | p1@AB527600 |
| 5.96e-34 | FFCP PHASE1:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853 | p@chr4:10057464..10057469, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr16:46766272..46766280,-#_48522f89037c59d8e980cd0dea55f853 | p@chr16:46766272..46766280, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853 | p@chr2:112009644..112009652, + |
| 5.96e-34 | FFCP PHASE1:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853 | p@chr20:54998100..54998106, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr2:112009644..112009652,+#_48522f89037c59d8e980cd0dea55f853 | p@chr2:112009644..112009652, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr4:10057464..10057469,+#_48522f89037c59d8e980cd0dea55f853 | p@chr4:10057464..10057469, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr17:10560452..10560487,-#_48522f89037c59d8e980cd0dea55f853 | p@chr17:10560452..10560487, - |
| 5.96e-34 | FFCP PHASE1:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853 | p@chr13:46542969..46542977, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr6:3759217..3759221,+#_48522f89037c59d8e980cd0dea55f853 | p@chr6:3759217..3759221, + |
| 5.96e-34 | FFCP PHASE2:Hg19::chr13:46542969..46542977,+#_48522f89037c59d8e980cd0dea55f853 | p@chr13:46542969..46542977, + |
| 5.96e-34 | FFCP PHASE1:Hg19::chr9:21499446..21499456,-#_48522f89037c59d8e980cd0dea55f853 | p@chr9:21499446..21499456, - |
| 5.96e-34 | FFCP PHASE2:Hg19::chr20:54998100..54998106,+#_48522f89037c59d8e980cd0dea55f853 | p@chr20:54998100..54998106, + |
| 5.96e-34 | FFCP PHASE1:Hg19::chr4:37636545..37636557,-#_48522f89037c59d8e980cd0dea55f853 | p@chr4:37636545..37636557, - |
| 1.08e-33 | FFCP PHASE2:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9 | p9@RNF214 |
| 1.08e-33 | FFCP PHASE1:Hg19::chr11:117152916..117152936,+#_202a7f406c31b0f145e46215291a2cd9 | p9@RNF214 |
| 2.87e-30 | FFCP PHASE2:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p7@Cd200r3 |
| 2.87e-30 | FFCP PHASE1:Mm9::chr16:44965362..44965370,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p7@Cd200r3 |
| 2.87e-30 | FFCP PHASE1:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p@chr10:124988598..124988600, + |
| 2.87e-30 | FFCP PHASE2:Mm9::chr10:124988598..124988600,+#_4fb6bd04e1177ece6b2c4d3160d4e220 | p@chr10:124988598..124988600, + |
| 5.62e-30 | FFCP PHASE2:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr17:29604869..29604892, - |
| 5.62e-30 | FFCP PHASE1:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p1@ENSMUST00000164855 |
| 5.62e-30 | FFCP PHASE1:Mm9::chr17:29604869..29604892,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr17:29604869..29604892, - |
| 5.62e-30 | FFCP PHASE2:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113254075..113254086, - |
| 5.62e-30 | FFCP PHASE2:Mm9::chr4:108520961..108521010,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p1@ENSMUST00000164855 |
| 5.62e-30 | FFCP PHASE1:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr1:87792029..87792037, - |
| 5.62e-30 | FFCP PHASE1:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr8:89139298..89139300, + |
| 5.62e-30 | FFCP PHASE2:Mm9::chr8:89139298..89139300,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr8:89139298..89139300, + |
| 5.62e-30 | FFCP PHASE1:Mm9::chr13:113254075..113254086,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113254075..113254086, - |
| 5.62e-30 | FFCP PHASE2:Mm9::chr1:87792029..87792037,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr1:87792029..87792037, - |
| 5.62e-30 | FFCP PHASE2:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p30@Dab2ip |
| 5.62e-30 | FFCP PHASE1:Mm9::chr2:35477718..35477720,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p30@Dab2ip |
| 5.62e-30 | FFCP PHASE2:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr16:18733244..18733286, - |
| 5.62e-30 | FFCP PHASE2:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113257676..113257683, + |
| 5.62e-30 | FFCP PHASE1:Mm9::chr16:18733244..18733286,-#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr16:18733244..18733286, - |
| 5.62e-30 | FFCP PHASE1:Mm9::chr13:113257676..113257683,+#_9d625e4f3b6ef9352dd9f7549dfa5042 | p@chr13:113257676..113257683, + |
| 1.1e-29 | FFCP PHASE1:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627 | p@chr2:122090551..122090560, + |
| 1.1e-29 | FFCP PHASE2:Mm9::chr2:122090551..122090560,+#_499e08c365a56e7aa6474a3881254627 | p@chr2:122090551..122090560, + |
| 3.11e-27 | FFCP PHASE1:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6b | p@chr2:27296691..27296699, - |
| 3.11e-27 | FFCP PHASE2:Hg19::chr2:27296691..27296699,-#_11e3283096304e432b95b25e254edb6b | p@chr2:27296691..27296699, - |
| 2.62e-23 | FFCP PHASE1:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130 | p@chr21:22496435..22496437, - |
| 2.62e-23 | FFCP PHASE1:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130 | p7@ATF7 |
| 2.62e-23 | FFCP PHASE2:Hg19::chr21:22496435..22496437,-#_e1df3863869ad537aeb8e17c71e41130 | p@chr21:22496435..22496437, - |
| 2.62e-23 | FFCP PHASE2:Hg19::chr12:53994805..53994817,-#_e1df3863869ad537aeb8e17c71e41130 | p7@ATF7 |
| 3.06e-23 | FFCP PHASE2:Mm9::chr4:61443256..61443260,-#_11f0a9b190f7fb77ea7ffa6ae4c2ef92 | p2@Mup12, p2@Mup16, p2@Mup17, p2@Mup19, p2@Mup9 |
| 3.06e-23 | FFCP PHASE1:Mm9::chr3:89539611..89539638,+#_11f0a9b190f7fb77ea7ffa6ae4c2ef92 | p@chr3:89539611..89539638, + |
