UBERON:0001043
From FANTOM5_SSTAR
| Name: | esophagus | |
|---|---|---|
| Namespace: | FANTOM | |
| Definition: | "Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993)." Wikipedia:Esophagus | |
| Xrefs: |
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| Synonyms: |
"gullet" EXACT [] "oesophagus" EXACT [] "��ｿｽ驛ｽophagus" RELATED LATIN [Wikipedia:Esophagus] | |
| Comments: | esophagus NOT part of gut in MA. part of gut in ZFA. part_of gut (via UGIT) in FMA. Consider splitting. Interspecies: The human oesophagus is 25 cm long and has a diameter of ca. 2 cm. Only little information was found on the oesophagus in rat, rabbit and pig. The oesophagus of rat (75 x 2 mm) and rabbit has no mucous glands and the cardia of the stomach has a well-developed sphincter, which prevents them from vomiting (Hebel and Stromberg, 1988; Manning et al., 1994). Morphologically the oesophagus is similar in man and pig; both are omnivores and have a non-keratinised epithelium, submucous glands and similar membrane enzymes. Like in humans, pigs can suffer from reflux oesophagitis and stress ulceration of the oesophagus. The pig oesophagus may therefore be a good model for investigation compared to the human oesophagus (Christie et al., 1995) | |
| Alt_id: | UBERON:FBbt_00005381-FMA_7131-MA_0000352-MIAA_0000048-XAO_0000127-ZFA_0000204 | |
| Subset: |
major_organ organ_slim uberon_slim vertebrate_core |
Ontology association<br>Each term has an is_a parent in the Uberon Ontology, which has a linkage to an another entity and FANTOM5 samples.Libraries were grouped into mutually exclusive facets according to the FANTOM5 sample ontology mapping to UBERON ontologies.<br><br>link to ontology dataset<br>data
Parents
| is_a: | UBERON:0004921(subdivision of digestive tract),UBERON:0005178(thoracic cavity element),UBERON:0013765(digestive system element) |
|---|---|
| develops_from: | UBERON:0001041(foregut) |
| part_of: | UBERON:0004908(upper digestive tract) |
Children
| is a: | FF:0102817 (esophageal cancer cell line) |
|---|---|
| derives from: | FF:0010015 (human esophagus - adult sample) |
| part of: | CL:0002252 (epithelial cell of esophagus),CL:0002599 (smooth muscle cell of the esophagus) |
Ontology Tree: Loaded from BioPortal
Ontorolgy tree(Small window open)
FF samples<br>It includes FANTOM5 samples that overlay the Uberon ontology
Human (Homo sapiens)
- 10015-101C6 (esophagus, adult, pool1)
- 10658-109C1
- 10660-109C3
- 10661-109C4
- 10665-109C8
- 11507-119G4 (Esophageal Epithelial Cells, donor1)
- 11508-119G5 (Smooth Muscle Cells - Esophageal, donor1)
- 11587-120G3 (Esophageal Epithelial Cells, donor2)
- 11588-120G4 (Smooth Muscle Cells - Esophageal, donor2)
- 11668-122G3 (Esophageal Epithelial Cells, donor3)
Enrichment analysis: top 100 FFCP enriched with this ontology term TOP 100 FANTOM5 Cage Peaks enriched with UBERON:0001043 (esophagus), sorted by p-values <br>Analyst: Hideya Kawaji<br><br>link to source dataset <br>human : data <br>mouse : data
Property "Property value" (as page type) with input value "UBPROP:0000001 "Anterior end of the alimentary canal lined with smooth muscle. Bounded anteriorly by a constriction in the pharynx. Bounded posteriorly by and increase in circular and/or longitudinal smooth muscle associated with the stomach.[AAO]" xsd:string" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.
