MCL coexpression mm9:133
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
GO ID | GO name | FDR corrected p-value |
---|---|---|
GO:0048731 | system development | 3.17060640578933e-07 |
GO:0007275 | multicellular organismal development | 4.02825301259622e-07 |
GO:0048856 | anatomical structure development | 7.97422795057435e-07 |
GO:0032502 | developmental process | 9.12510268051575e-06 |
GO:0032501 | multicellular organismal process | 1.08255785665892e-05 |
GO:0048513 | organ development | 1.17311696845874e-05 |
GO:0007399 | nervous system development | 3.11009248615317e-05 |
GO:0007423 | sensory organ development | 0.000159224236750079 |
GO:0007605 | sensory perception of sound | 0.000233166117341199 |
GO:0050954 | sensory perception of mechanical stimulus | 0.000259137051900052 |
GO:0043565 | sequence-specific DNA binding | 0.000442967931610447 |
GO:0003700 | transcription factor activity | 0.0014541529760685 |
GO:0060041 | retina development in camera-type eye | 0.00176540729959801 |
GO:0043010 | camera-type eye development | 0.00298502399539803 |
GO:0048869 | cellular developmental process | 0.00298502399539803 |
GO:0030154 | cell differentiation | 0.00298502399539803 |
GO:0022829 | wide pore channel activity | 0.00509830734741156 |
GO:0005243 | gap junction channel activity | 0.00509830734741156 |
GO:0005922 | connexon complex | 0.00509830734741156 |
GO:0001654 | eye development | 0.00617227078149919 |
GO:0048468 | cell development | 0.00617227078149919 |
GO:0030182 | neuron differentiation | 0.00702146208390581 |
GO:0005921 | gap junction | 0.00852112694554378 |
GO:0005212 | structural constituent of eye lens | 0.00852112694554378 |
GO:0048699 | generation of neurons | 0.0100366314732522 |
GO:0022008 | neurogenesis | 0.0125660305513375 |
GO:0003676 | nucleic acid binding | 0.014097615774352 |
GO:0016070 | RNA metabolic process | 0.014097615774352 |
GO:0065007 | biological regulation | 0.0143830397897842 |
GO:0006355 | regulation of transcription, DNA-dependent | 0.0154715056464117 |
GO:0006351 | transcription, DNA-dependent | 0.0156396531110116 |
GO:0032774 | RNA biosynthetic process | 0.0156396531110116 |
GO:0060040 | retinal bipolar neuron differentiation | 0.0156396531110116 |
GO:0014067 | negative regulation of phosphoinositide 3-kinase cascade | 0.0156396531110116 |
GO:0003677 | DNA binding | 0.0158314397610302 |
GO:0045449 | regulation of transcription | 0.0165934957700897 |
GO:0014704 | intercalated disc | 0.0165934957700897 |
GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0182292920822626 |
GO:0005667 | transcription factor complex | 0.0182292920822626 |
GO:0006350 | transcription | 0.0188991732135179 |
GO:0009653 | anatomical structure morphogenesis | 0.0210665078456802 |
GO:0010468 | regulation of gene expression | 0.0221428222969416 |
GO:0009649 | entrainment of circadian clock | 0.0221428222969416 |
GO:0043547 | positive regulation of GTPase activity | 0.0221428222969416 |
GO:0014066 | regulation of phosphoinositide 3-kinase cascade | 0.0221428222969416 |
GO:0006423 | cysteinyl-tRNA aminoacylation | 0.0221428222969416 |
GO:0004817 | cysteine-tRNA ligase activity | 0.0221428222969416 |
GO:0060042 | retina morphogenesis in camera-type eye | 0.0221428222969416 |
GO:0031323 | regulation of cellular metabolic process | 0.0244617526616222 |
GO:0050794 | regulation of cellular process | 0.0244617526616222 |
GO:0009887 | organ morphogenesis | 0.0265603447616523 |
GO:0010467 | gene expression | 0.027415445658086 |
GO:0019222 | regulation of metabolic process | 0.0274710781192674 |
GO:0044451 | nucleoplasm part | 0.0274710781192674 |
GO:0014065 | phosphoinositide 3-kinase cascade | 0.0274710781192674 |
GO:0048676 | axon extension involved in development | 0.0274710781192674 |
GO:0042473 | outer ear morphogenesis | 0.0274710781192674 |
GO:0004887 | thyroid hormone receptor activity | 0.0274710781192674 |
GO:0043583 | ear development | 0.0292549535875154 |
GO:0005654 | nucleoplasm | 0.0313707201051854 |
GO:0051898 | negative regulation of protein kinase B signaling cascade | 0.0342443568458092 |
GO:0005793 | ER-Golgi intermediate compartment | 0.0342443568458092 |
GO:0051896 | regulation of protein kinase B signaling cascade | 0.0408052151797968 |
GO:0046626 | regulation of insulin receptor signaling pathway | 0.0408052151797968 |
GO:0043209 | myelin sheath | 0.0408052151797968 |
GO:0050789 | regulation of biological process | 0.0416096075125384 |
GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.0417836073135098 |
GO:0045165 | cell fate commitment | 0.0432855424115458 |
GO:0042474 | middle ear morphogenesis | 0.0460998529379166 |
GO:0031981 | nuclear lumen | 0.0493290610772881 |
GO:0007601 | visual perception | 0.0498269178099654 |
GO:0050953 | sensory perception of light stimulus | 0.0499982868278047 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Ontology term | p-value | n |
---|---|---|
eye | 5.61e-38 | 9 |
camera-type eye | 5.61e-38 | 9 |
simple eye | 5.61e-38 | 9 |
immature eye | 5.61e-38 | 9 |
ocular region | 5.61e-38 | 9 |
visual system | 5.61e-38 | 9 |
face | 5.61e-38 | 9 |
optic cup | 5.61e-38 | 9 |
optic vesicle | 5.61e-38 | 9 |
eye primordium | 5.61e-38 | 9 |
subdivision of head | 6.25e-31 | 11 |
sense organ | 2.76e-28 | 12 |
sensory system | 2.76e-28 | 12 |
entire sense organ system | 2.76e-28 | 12 |
head | 4.78e-26 | 13 |
ectodermal placode | 4.78e-26 | 13 |
craniocervical region | 8.15e-09 | 36 |
pre-chordal neural plate | 7.42e-08 | 49 |
anterior region of body | 3.22e-07 | 43 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
Motifs | -log10(p-value) |
---|---|
MA0003.1 | 2.52929 |
MA0004.1 | 0.246821 |
MA0006.1 | 0.0734747 |
MA0007.1 | 0.0478182 |
MA0009.1 | 0.32515 |
MA0014.1 | 0.0519294 |
MA0017.1 | 0.0226026 |
MA0019.1 | 0.144022 |
MA0024.1 | 0.0804853 |
MA0025.1 | 0.225742 |
MA0027.1 | 1.48273 |
MA0028.1 | 0.00115733 |
MA0029.1 | 0.0722024 |
MA0030.1 | 0.0746529 |
MA0031.1 | 0.0619169 |
MA0038.1 | 0.0701547 |
MA0040.1 | 0.104202 |
MA0041.1 | 0.221769 |
MA0042.1 | 0.0499362 |
MA0043.1 | 0.145499 |
MA0046.1 | 0.115002 |
MA0048.1 | 0.135775 |
MA0050.1 | 0.0818966 |
MA0051.1 | 0.624557 |
MA0052.1 | 0.349675 |
MA0055.1 | 0.389529 |
MA0056.1 | 0 |
MA0057.1 | 0.829526 |
MA0058.1 | 0.299059 |
MA0059.1 | 0.11381 |
MA0060.1 | 0.00631716 |
MA0061.1 | 0.876373 |
MA0063.1 | 0 |
MA0066.1 | 1.19506 |
MA0067.1 | 0.301247 |
MA0068.1 | 0.0276468 |
MA0069.1 | 0.350086 |
MA0070.1 | 0.33843 |
MA0071.1 | 0.763745 |
MA0072.1 | 0.328374 |
MA0073.1 | 3.73596 |
MA0074.1 | 0.272587 |
MA0076.1 | 0.00248208 |
MA0077.1 | 2.7697 |
MA0078.1 | 1.90623 |
MA0081.1 | 0.255167 |
MA0083.1 | 0.874477 |
MA0084.1 | 0.562229 |
MA0087.1 | 0.779274 |
MA0088.1 | 0.289428 |
MA0089.1 | 0 |
MA0090.1 | 0.0939368 |
MA0091.1 | 0.44548 |
MA0092.1 | 0.317657 |
MA0093.1 | 0.270032 |
MA0095.1 | 0 |
MA0098.1 | 0 |
MA0100.1 | 0.252958 |
MA0101.1 | 0.359812 |
MA0103.1 | 0.0624834 |
MA0105.1 | 0.52003 |
MA0106.1 | 4.19819 |
MA0107.1 | 0.0572829 |
MA0108.2 | 0.663057 |
MA0109.1 | 0 |
MA0111.1 | 0.0451719 |
MA0113.1 | 0.661959 |
MA0114.1 | 0.0293833 |
MA0115.1 | 0.146985 |
MA0116.1 | 1.31366 |
MA0117.1 | 0.407968 |
MA0119.1 | 0.00608287 |
MA0122.1 | 0.140445 |
MA0124.1 | 0.264049 |
MA0125.1 | 0.215442 |
MA0130.1 | 0 |
MA0131.1 | 0.0351382 |
MA0132.1 | 0 |
MA0133.1 | 0 |
MA0135.1 | 0.165378 |
MA0136.1 | 0.0566883 |
MA0139.1 | 0.729131 |
MA0140.1 | 0.121451 |
MA0141.1 | 0.561159 |
MA0142.1 | 0.457557 |
MA0143.1 | 0.437405 |
MA0144.1 | 0.00472046 |
MA0145.1 | 0.214749 |
MA0146.1 | 0.757519 |
MA0147.1 | 0.213222 |
MA0148.1 | 0.150209 |
MA0149.1 | 0.000913137 |
MA0062.2 | 0.000157215 |
MA0035.2 | 0.125878 |
MA0039.2 | 0.0103803 |
MA0138.2 | 0.0332509 |
MA0002.2 | 0.0644266 |
MA0137.2 | 0.0121743 |
MA0104.2 | 0.416234 |
MA0047.2 | 0.0149432 |
MA0112.2 | 1.63383 |
MA0065.2 | 0.0532747 |
MA0150.1 | 1.37239 |
MA0151.1 | 0 |
MA0152.1 | 0.596614 |
MA0153.1 | 0.174838 |
MA0154.1 | 0.249408 |
MA0155.1 | 2.22476 |
MA0156.1 | 0.0691745 |
MA0157.1 | 0.0472741 |
MA0158.1 | 0 |
MA0159.1 | 1.31188 |
MA0160.1 | 0.68783 |
MA0161.1 | 0 |
MA0162.1 | 0.159609 |
MA0163.1 | 1.54248 |
MA0164.1 | 0.308679 |
MA0080.2 | 0.0247642 |
MA0018.2 | 0.0615045 |
MA0099.2 | 0.306082 |
MA0079.2 | 1.36607 |
MA0102.2 | 0.607761 |
MA0258.1 | 0.75214 |
MA0259.1 | 0.184363 |
MA0442.1 | 0 |