MCL coexpression mm9:3465

Phase1 CAGE Peaks

	Short description
Mm9::chr4:147278894..147278908,-	p9@Mfn2
Mm9::chr4:147278917..147278973,-	p3@Mfn2
Mm9::chr9:57400529..57400564,-	p1@Mpi

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004476	mannose-6-phosphate isomerase activity	0.0142970607841504
GO:0008053	mitochondrial fusion	0.0142970607841504
GO:0001825	blastocyst formation	0.0142970607841504
GO:0048284	organelle fusion	0.0142970607841504
GO:0006013	mannose metabolic process	0.0158838821556014
GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses	0.0158838821556014
GO:0048593	camera-type eye morphogenesis	0.0226289501895935
GO:0005741	mitochondrial outer membrane	0.0226289501895935
GO:0031968	organelle outer membrane	0.0232887003681267
GO:0001824	blastocyst development	0.0295270205508354
GO:0016860	intramolecular oxidoreductase activity	0.0336894383477307
GO:0048592	eye morphogenesis	0.0336894383477307
GO:0019867	outer membrane	0.0336894383477307
GO:0007005	mitochondrion organization and biogenesis	0.0455381975985543
GO:0043010	camera-type eye development	0.0475667757442302

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
structure with developmental contribution from neural crest	1.73e-10	92
intestine	4.00e-08	31
primary circulatory organ	4.60e-08	18
heart	4.60e-08	18
primitive heart tube	4.60e-08	18
primary heart field	4.60e-08	18
anterior lateral plate mesoderm	4.60e-08	18
heart tube	4.60e-08	18
heart primordium	4.60e-08	18
cardiac mesoderm	4.60e-08	18
cardiogenic plate	4.60e-08	18
heart rudiment	4.60e-08	18

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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