MCL coexpression mm9:1742

Phase1 CAGE Peaks

	Short description
Mm9::chr1:138850177..138850182,-	p11@Nr5a2
Mm9::chr2:120926896..120926901,-	p@chr2:120926896..120926901 -
Mm9::chr5:102088225..102088234,+	p@chr5:102088225..102088234 +
Mm9::chr5:102094214..102094230,-	p1@Nkx6-1
Mm9::chr7:31238807..31238830,-	p@chr7:31238807..31238830 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0014015	positive regulation of gliogenesis	0.0122007989608258
GO:0045687	positive regulation of glial cell differentiation	0.0122007989608258
GO:0043565	sequence-specific DNA binding	0.0122007989608258
GO:0014014	negative regulation of gliogenesis	0.0122007989608258
GO:0045686	negative regulation of glial cell differentiation	0.0122007989608258
GO:0031018	endocrine pancreas development	0.0122007989608258
GO:0045685	regulation of glial cell differentiation	0.0122007989608258
GO:0014013	regulation of gliogenesis	0.0122007989608258
GO:0008206	bile acid metabolic process	0.0132544626031471
GO:0031016	pancreas development	0.0137035799856242
GO:0042632	cholesterol homeostasis	0.0137035799856242
GO:0055088	lipid homeostasis	0.0137035799856242
GO:0055092	sterol homeostasis	0.0137035799856242
GO:0003700	transcription factor activity	0.0137035799856242
GO:0010001	glial cell differentiation	0.0260005569320371
GO:0042063	gliogenesis	0.0260005569320371
GO:0045597	positive regulation of cell differentiation	0.0260005569320371
GO:0003707	steroid hormone receptor activity	0.0260005569320371
GO:0004879	ligand-dependent nuclear receptor activity	0.0260005569320371
GO:0035270	endocrine system development	0.0260005569320371
GO:0051094	positive regulation of developmental process	0.0355754965155316
GO:0045596	negative regulation of cell differentiation	0.0374986713342052
GO:0006355	regulation of transcription, DNA-dependent	0.0374986713342052
GO:0006351	transcription, DNA-dependent	0.0374986713342052
GO:0032774	RNA biosynthetic process	0.0374986713342052
GO:0003677	DNA binding	0.0374986713342052
GO:0045449	regulation of transcription	0.0374986713342052
GO:0019219	regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	0.0374986713342052
GO:0006350	transcription	0.0374986713342052
GO:0051093	negative regulation of developmental process	0.0374986713342052
GO:0010468	regulation of gene expression	0.0383624089928053
GO:0031323	regulation of cellular metabolic process	0.0402726768672539
GO:0019222	regulation of metabolic process	0.0419935832871114
GO:0016070	RNA metabolic process	0.0429385142340032
GO:0008202	steroid metabolic process	0.0432249066404042
GO:0045595	regulation of cell differentiation	0.0459100452104763

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
pancreas	1.23e-24	12
viscus	2.31e-18	19
body cavity	1.42e-08	37
body cavity or lining	1.42e-08	37
body cavity precursor	2.66e-08	38
anatomical cavity	4.82e-08	39

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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