MCL coexpression mm9:767

Phase1 CAGE Peaks

	Short description
Mm9::chr10:68614144..68614154,+	p18@Rhobtb1
Mm9::chr13:54169098..54169109,+	p@chr13:54169098..54169109 +
Mm9::chr1:129625982..129625995,+	p1@Acmsd
Mm9::chr1:129626007..129626012,+	p2@Acmsd
Mm9::chr5:45835830..45835845,-	p4@Qdpr
Mm9::chr6:129483226..129483267,+	p1@Gabarapl1
Mm9::chr6:129483269..129483286,+	p5@Gabarapl1
Mm9::chr7:59143316..59143330,+	p@chr7:59143316..59143330 +
Mm9::chr9:21796534..21796550,-	p@chr9:21796534..21796550 -

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0004155	6,7-dihydropteridine reductase activity	0.00803520882412023
GO:0046874	quinolinate metabolic process	0.00803520882412023
GO:0001760	aminocarboxymuconate-semialdehyde decarboxylase activity	0.00803520882412023
GO:0046146	tetrahydrobiopterin metabolic process	0.0284510300394729
GO:0006729	tetrahydrobiopterin biosynthetic process	0.0284510300394729
GO:0005776	autophagic vacuole	0.0284510300394729
GO:0043648	dicarboxylic acid metabolic process	0.0284510300394729
GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor	0.0284510300394729
GO:0042559	pteridine and derivative biosynthetic process	0.0284510300394729
GO:0019438	aromatic compound biosynthetic process	0.0284510300394729
GO:0042558	pteridine and derivative metabolic process	0.0284510300394729
GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors	0.0400924815146338
GO:0016831	carboxy-lyase activity	0.0480793553574479

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
metabolising cell	5.18e-10	5
endopolyploid cell	5.18e-10	5
parenchymal cell	5.18e-10	5
polyploid cell	5.18e-10	5
hepatocyte	5.18e-10	5

Uber Anatomy

Ontology term	p-value	n
abdomen element	2.32e-22	49
abdominal segment element	2.32e-22	49
abdominal segment of trunk	2.32e-22	49
abdomen	2.32e-22	49
liver	2.53e-20	22
epithelial sac	2.53e-20	22
digestive gland	2.53e-20	22
epithelium of foregut-midgut junction	2.53e-20	22
anatomical boundary	2.53e-20	22
hepatobiliary system	2.53e-20	22
foregut-midgut junction	2.53e-20	22
hepatic diverticulum	2.53e-20	22
liver primordium	2.53e-20	22
septum transversum	2.53e-20	22
liver bud	2.53e-20	22
digestive tract diverticulum	2.56e-19	23
sac	2.56e-19	23
exocrine gland	1.51e-17	25
exocrine system	1.51e-17	25
mesenchyme	4.73e-17	61
entire embryonic mesenchyme	4.73e-17	61
subdivision of trunk	2.08e-15	66
trunk region element	4.10e-12	79
trunk	4.52e-10	90
trunk mesenchyme	6.39e-10	45
kidney	1.24e-09	14
kidney mesenchyme	1.24e-09	14
upper urinary tract	1.24e-09	14
kidney rudiment	1.24e-09	14
kidney field	1.24e-09	14
epithelial tube	4.84e-08	47
urinary system structure	2.89e-07	18
renal system	7.89e-07	19

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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