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Coexpression cluster:C3742

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Full id: C3742_Dendritic_granulocyte_Smooth_Mesenchymal_Fibroblast_merkel_Prostate



Phase1 CAGE Peaks

Hg19::chr18:77557932..77557943,+p@chr18:77557932..77557943
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Hg19::chr18:77557948..77557968,+p@chr18:77557948..77557968
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Hg19::chr18:77557973..77557984,+p@chr18:77557973..77557984
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism1.49e-13114
telencephalon1.08e-1234
cerebral hemisphere3.21e-1232
brain1.97e-1168
future brain1.97e-1168
central nervous system2.08e-1181
brain grey matter3.29e-1134
gray matter3.29e-1134
neural tube3.91e-1156
neural rod3.91e-1156
future spinal cord3.91e-1156
neural keel3.91e-1156
organ system subdivision4.07e-11223
regional part of cerebral cortex6.70e-1122
regional part of telencephalon1.18e-1032
regional part of forebrain8.18e-1041
forebrain8.18e-1041
anterior neural tube8.18e-1041
future forebrain8.18e-1041
regional part of nervous system1.19e-0953
regional part of brain1.19e-0953
nervous system1.45e-0989
cerebral cortex2.75e-0925
pallium2.75e-0925
neural plate3.11e-0982
presumptive neural plate3.11e-0982
pre-chordal neural plate6.12e-0961
neurectoderm1.66e-0886
neocortex1.67e-0820
brain vasculature1.54e-075
ecto-epithelium1.97e-07104
multi-tissue structure6.15e-07342


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL3#602223.03140186915890.002464674760842910.013851809037705
CTCF#1066435.360256373075030.0064925092527670.0279340518188075
RAD21#5885310.35503389545630.0009004912073565420.00663888191480374
ZNF263#1012738.221841637010680.001799043925565870.0109372110450069



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.