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Coexpression cluster:C2866

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Full id: C2866_Fibroblast_Preadipocyte_rhabdomyosarcoma_Myoblast_mesenchymal_Smooth_liposarcoma



Phase1 CAGE Peaks

Hg19::chr6:56819398..56819427,-p13@DST
Hg19::chr6:56819429..56819490,-p10@DST
Hg19::chr6:56819494..56819509,-p28@DST
Hg19::chr6:56819522..56819652,-p3@DST


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
fibroblast2.27e-1776
skin fibroblast2.86e-1123
non-terminally differentiated cell2.60e-08106
Uber Anatomy
Ontology termp-valuen
central nervous system4.09e-2481
brain4.94e-2368
future brain4.94e-2368
nervous system5.94e-2389
neural tube1.13e-2256
neural rod1.13e-2256
future spinal cord1.13e-2256
neural keel1.13e-2256
regional part of nervous system2.88e-2153
regional part of brain2.88e-2153
structure with developmental contribution from neural crest4.16e-20132
neural plate2.85e-1782
presumptive neural plate2.85e-1782
regional part of forebrain6.47e-1641
forebrain6.47e-1641
anterior neural tube6.47e-1641
future forebrain6.47e-1641
ectoderm-derived structure9.46e-16171
ectoderm9.46e-16171
presumptive ectoderm9.46e-16171
neurectoderm2.41e-1586
brain grey matter8.73e-1434
gray matter8.73e-1434
ecto-epithelium9.15e-14104
telencephalon3.06e-1334
regional part of telencephalon1.21e-1232
cerebral hemisphere1.35e-1232
pre-chordal neural plate5.05e-1161
cerebral cortex7.49e-1025
pallium7.49e-1025
organ system subdivision1.94e-09223
regional part of cerebral cortex2.10e-0922
multi-tissue structure5.04e-09342
neocortex1.23e-0820
skin of body4.79e-0841
posterior neural tube4.82e-0815
chordal neural plate4.82e-0815
integument1.38e-0746
integumental system1.38e-0746
segmental subdivision of nervous system4.46e-0713


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90546.336201576962630.0006203100587215640.00513511114638724
E2F1#186944.907389214879320.001724022357361790.0106781621978714
E2F6#187645.017155731697390.00157802193473060.0099907270151145
EBF1#187948.9064668465690.00015887907472010.00199990016689075
EGR1#195844.988179094810140.001615011500076050.0101633035705256
HEY1#2346244.040111043105710.00375304636917980.018657864135128
MAFK#7975427.10073313782991.85228494563408e-066.85752525477058e-05
NFE2#4778477.2042606516292.80776035215453e-081.91910787577661e-06
PAX5#507946.669565531177830.0005052774169483260.00444834090438053
SIN3A#2594245.408884726815140.001168172384885160.0079802953757863
TAF1#687243.343046285745290.008005664898701650.0323269268618737
YY1#752844.911170749853860.00171871838055440.0107062644009735
ZBTB7A#5134135.513931980906920.009038352821081090.0342584209291169



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.