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Coexpression cluster:C1486

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Full id: C1486_Fibroblast_Mesenchymal_Hair_mesenchymal_Preadipocyte_Smooth_mesothelioma



Phase1 CAGE Peaks

Hg19::chr21:28336890..28336913,-p@chr21:28336890..28336913
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Hg19::chr3:170458920..170458937,-p@chr3:170458920..170458937
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Hg19::chr3:58045307..58045310,-p@chr3:58045307..58045310
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Hg19::chr3:71222202..71222216,-p@chr3:71222202..71222216
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Hg19::chr8:49342856..49342863,-p1@LOC286068
Hg19::chr9:118919556..118919561,+p@chr9:118919556..118919561
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
integument7.61e-1546
integumental system7.61e-1546
skin of body2.43e-1341
artery wall1.17e-114
tunica adventitia of artery1.17e-114
adventitia1.17e-114
tunica adventitia of blood vessel1.17e-114
aorta tunica adventitia1.17e-114
aorta wall1.17e-114
skeletal muscle tissue3.68e-0862
striated muscle tissue3.68e-0862
myotome3.68e-0862
muscle tissue8.76e-0864
musculature8.76e-0864
musculature of body8.76e-0864
hair root sheath7.06e-072
hair outer root sheath7.06e-072
bulb of hair follicle7.06e-072
surface structure9.25e-0799
Disease
Ontology termp-valuen
musculoskeletal system disease2.26e-145
myotonic disease2.26e-145
muscle tissue disease2.26e-145
myopathy2.26e-145
muscular disease2.26e-145
myotonic dystrophy2.26e-145


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105145.314098417216540.003008047293917460.0159819632359692



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.