Personal tools

Coexpression cluster:C2267

From FANTOM5_SSTAR

Revision as of 13:48, 19 October 2012 by Autoedit (talk | contribs)
Jump to: navigation, search


Full id: C2267_neuroblastoma_spleen_amygdala_neuroectodermal_lung_occipital_parietal



Phase1 CAGE Peaks

Hg19::chr13:58204232..58204248,+p@chr13:58204232..58204248
+
Hg19::chr13:58205869..58205900,+p2@PCDH17
Hg19::chr13:58205930..58205965,+p1@PCDH17
Hg19::chr13:58206234..58206253,+p5@PCDH17


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism4.18e-69114
neural tube1.40e-5456
neural rod1.40e-5456
future spinal cord1.40e-5456
neural keel1.40e-5456
regional part of nervous system3.68e-5153
regional part of brain3.68e-5153
nervous system1.13e-4889
central nervous system1.68e-4681
neurectoderm2.98e-4686
regional part of forebrain2.59e-4241
forebrain2.59e-4241
anterior neural tube2.59e-4241
future forebrain2.59e-4241
brain3.56e-4268
future brain3.56e-4268
neural plate3.86e-4282
presumptive neural plate3.86e-4282
telencephalon2.34e-3834
brain grey matter3.08e-3834
gray matter3.08e-3834
regional part of telencephalon4.23e-3632
cerebral hemisphere5.06e-3632
pre-chordal neural plate1.13e-3161
ecto-epithelium1.09e-30104
structure with developmental contribution from neural crest1.48e-29132
ectoderm-derived structure1.56e-29171
ectoderm1.56e-29171
presumptive ectoderm1.56e-29171
cerebral cortex5.81e-2825
pallium5.81e-2825
organ system subdivision9.95e-27223
regional part of cerebral cortex1.90e-2622
neocortex4.65e-2420
anatomical cluster5.92e-21373
tube2.01e-20192
multi-tissue structure9.44e-17342
anatomical conduit9.22e-16240
epithelium1.03e-14306
cell layer2.79e-14309
embryo4.14e-14592
organ part5.64e-14218
posterior neural tube4.88e-1315
chordal neural plate4.88e-1315
multi-cellular organism1.70e-12656
embryonic structure3.67e-12564
germ layer4.82e-12560
germ layer / neural crest4.82e-12560
embryonic tissue4.82e-12560
presumptive structure4.82e-12560
germ layer / neural crest derived structure4.82e-12560
epiblast (generic)4.82e-12560
basal ganglion5.66e-129
nuclear complex of neuraxis5.66e-129
aggregate regional part of brain5.66e-129
collection of basal ganglia5.66e-129
cerebral subcortex5.66e-129
developing anatomical structure6.33e-12581
neural nucleus1.30e-119
nucleus of brain1.30e-119
segmental subdivision of nervous system1.05e-1013
segmental subdivision of hindbrain6.10e-1012
hindbrain6.10e-1012
presumptive hindbrain6.10e-1012
telencephalic nucleus1.45e-097
temporal lobe3.17e-096
organ1.79e-08503
anatomical system3.37e-08624
anatomical group4.05e-08625
gyrus4.22e-086
limbic system1.39e-075
brainstem1.57e-076
regional part of metencephalon4.23e-079
metencephalon4.23e-079
future metencephalon4.23e-079
occipital lobe5.39e-075
Disease
Ontology termp-valuen
neuroectodermal tumor5.66e-0810


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
GATA2#2624412.7449317335543.78864877853583e-050.000720339868526313
GATA3#2625320.42738726790450.0001924415576258320.00231922499848652



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.