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Coexpression cluster:C1414

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Full id: C1414_Wilms_cerebellum_parietal_hippocampus_medial_caudate_middle



Phase1 CAGE Peaks

Hg19::chr15:88740321..88740326,-p@chr15:88740321..88740326
-
Hg19::chr15:88799384..88799430,-p3@NTRK3
Hg19::chr15:88799702..88799755,-p5@NTRK3
Hg19::chr15:88799926..88799941,-p2@NTRK3
Hg19::chr15:88799948..88799977,-p1@NTRK3
Hg19::chr7:54609955..54609962,+p13@VSTM2A


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0043121neurotrophin binding0.00853644177557988



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism3.85e-57114
central nervous system1.08e-5581
nervous system1.12e-5489
neural tube2.52e-5256
neural rod2.52e-5256
future spinal cord2.52e-5256
neural keel2.52e-5256
regional part of nervous system1.43e-4953
regional part of brain1.43e-4953
brain3.36e-4768
future brain3.36e-4768
neural plate1.19e-4282
presumptive neural plate1.19e-4282
neurectoderm1.41e-4086
regional part of forebrain1.97e-3941
forebrain1.97e-3941
anterior neural tube1.97e-3941
future forebrain1.97e-3941
structure with developmental contribution from neural crest1.59e-35132
brain grey matter2.27e-3434
gray matter2.27e-3434
telencephalon2.70e-3434
ectoderm-derived structure7.23e-33171
ectoderm7.23e-33171
presumptive ectoderm7.23e-33171
cerebral hemisphere1.10e-3232
regional part of telencephalon1.61e-3232
ecto-epithelium5.36e-32104
pre-chordal neural plate4.46e-2961
cerebral cortex4.95e-2625
pallium4.95e-2625
organ system subdivision8.71e-26223
regional part of cerebral cortex6.33e-2422
neocortex7.13e-2220
anatomical cluster3.51e-20373
tube7.00e-16192
posterior neural tube1.35e-1315
chordal neural plate1.35e-1315
anatomical conduit9.20e-13240
segmental subdivision of nervous system7.68e-1213
multi-tissue structure1.05e-11342
segmental subdivision of hindbrain4.55e-1112
hindbrain4.55e-1112
presumptive hindbrain4.55e-1112
organ3.25e-10503
organ part4.28e-10218
basal ganglion5.62e-109
nuclear complex of neuraxis5.62e-109
aggregate regional part of brain5.62e-109
collection of basal ganglia5.62e-109
cerebral subcortex5.62e-109
neural nucleus1.06e-099
nucleus of brain1.06e-099
embryo1.33e-09592
multi-cellular organism7.63e-09656
regional part of metencephalon1.86e-089
metencephalon1.86e-089
future metencephalon1.86e-089
temporal lobe2.47e-086
cell layer3.10e-08309
developing anatomical structure4.48e-08581
telencephalic nucleus6.39e-087
embryonic structure7.97e-08564
germ layer8.03e-08560
germ layer / neural crest8.03e-08560
embryonic tissue8.03e-08560
presumptive structure8.03e-08560
germ layer / neural crest derived structure8.03e-08560
epiblast (generic)8.03e-08560
epithelium9.92e-08306
gyrus1.81e-076
brainstem6.72e-076
anatomical system8.33e-07624


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.