MCL coexpression mm9:645

Phase1 CAGE Peaks

	Short description
Mm9::chr11:100750866..100750891,-	p@chr11:100750866..100750891 -
Mm9::chr12:60289431..60289446,+	p@chr12:60289431..60289446 +
Mm9::chr13:34274534..34274552,-	p@chr13:34274534..34274552 -
Mm9::chr15:12251371..12251380,+	p5@Golph3
Mm9::chr15:96518755..96518774,-	p@chr15:96518755..96518774 -
Mm9::chr19:46589812..46589830,+	p@chr19:46589812..46589830 +
Mm9::chr2:133378740..133378753,+	p2@Bmp2
Mm9::chr4:59489147..59489161,-	p@chr4:59489147..59489161 -
Mm9::chr5:65213356..65213412,+	p6@Klf3
Mm9::chr5:65213459..65213485,+	p12@Klf3
Mm9::chr5:65214223..65214249,+	p@chr5:65214223..65214249 +

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0048711	positive regulation of astrocyte differentiation	0.0274145700786072
GO:0048710	regulation of astrocyte differentiation	0.0274145700786072
GO:0014015	positive regulation of gliogenesis	0.0274145700786072
GO:0045687	positive regulation of glial cell differentiation	0.0274145700786072
GO:0045778	positive regulation of ossification	0.0274145700786072
GO:0046852	positive regulation of bone remodeling	0.0274145700786072
GO:0045669	positive regulation of osteoblast differentiation	0.0274145700786072
GO:0048708	astrocyte differentiation	0.0274145700786072
GO:0001837	epithelial to mesenchymal transition	0.0274145700786072
GO:0014013	regulation of gliogenesis	0.0274145700786072
GO:0045685	regulation of glial cell differentiation	0.0274145700786072
GO:0045667	regulation of osteoblast differentiation	0.0334984357436158
GO:0035051	cardiac cell differentiation	0.0386425113870819
GO:0001658	ureteric bud branching	0.0430481817489659
GO:0030282	bone mineralization	0.0495686167483751
GO:0030278	regulation of ossification	0.0495686167483751
GO:0001649	osteoblast differentiation	0.0495686167483751
GO:0030509	BMP signaling pathway	0.0495686167483751
GO:0046850	regulation of bone remodeling	0.0495686167483751
GO:0001657	ureteric bud development	0.0495686167483751
GO:0015171	amino acid transmembrane transporter activity	0.0495686167483751
GO:0042475	odontogenesis of dentine-containing teeth	0.0495686167483751
GO:0042476	odontogenesis	0.0495686167483751
GO:0010001	glial cell differentiation	0.0495686167483751
GO:0048762	mesenchymal cell differentiation	0.0495686167483751
GO:0014031	mesenchymal cell development	0.0495686167483751
GO:0042063	gliogenesis	0.0495686167483751
GO:0006865	amino acid transport	0.0495686167483751
GO:0001656	metanephros development	0.0495686167483751
GO:0045597	positive regulation of cell differentiation	0.0495686167483751
GO:0007179	transforming growth factor beta receptor signaling pathway	0.0495686167483751

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
endoderm-derived structure	1.29e-10	118
endoderm	1.29e-10	118
presumptive endoderm	1.29e-10	118
organism subdivision	6.60e-10	150
digestive system	6.94e-10	116
digestive tract	6.94e-10	116
primitive gut	6.94e-10	116
subdivision of digestive tract	1.02e-09	114
subdivision of trunk	3.42e-08	66
trunk region element	5.32e-08	79
abdomen element	6.05e-08	49
abdominal segment element	6.05e-08	49
abdominal segment of trunk	6.05e-08	49
abdomen	6.05e-08	49
foregut	7.38e-08	80
trunk	8.32e-08	90
primordium	4.25e-07	134
multi-cellular organism	4.43e-07	333

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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