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Coexpression cluster:C791

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Full id: C791_salivary_epididymis_submaxillary_ductus_seminal_parotid_colon



Phase1 CAGE Peaks

Hg19::chr11:111176214..111176228,-p5@C11orf92
Hg19::chr11:70021323..70021345,-p@chr11:70021323..70021345
-
Hg19::chr17:26800592..26800609,+p5@SLC13A2
Hg19::chr1:1266654..1266669,+p1@TAS1R3
Hg19::chr1:17846690..17846694,+p11@ARHGEF10L
Hg19::chr3:46491385..46491395,-p@chr3:46491385..46491395
-
Hg19::chr7:25702754..25702765,-p3@ENST00000446840
p3@uc003sxp.1
Hg19::chr8:107630226..107630237,+p18@OXR1
Hg19::chr8:107630282..107630302,+p13@OXR1
Hg19::chr8:107630313..107630329,+p10@OXR1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0015361low affinity sodium:dicarboxylate symporter activity0.00513341279036033
GO:0050916sensory perception of sweet taste0.00513341279036033
GO:0050917sensory perception of umami taste0.00513341279036033
GO:0033041sweet taste receptor activity0.00513341279036033
GO:0001582detection of chemical stimulus during sensory perception of sweet taste0.00513341279036033
GO:0050907detection of chemical stimulus during sensory perception0.012830698841576
GO:0050912detection of chemical stimulus during sensory perception of taste0.012830698841576
GO:0042221response to chemical stimulus0.0170977803924141
GO:0008527taste receptor activity0.0170977803924141
GO:0017153sodium:dicarboxylate symporter activity0.0170977803924141
GO:0005310dicarboxylic acid transmembrane transporter activity0.0170977803924141
GO:0009593detection of chemical stimulus0.0170977803924141
GO:0016998cell wall catabolic process0.0170977803924141
GO:0010382cell wall metabolic process0.0170977803924141
GO:0007047cell wall organization and biogenesis0.0170977803924141
GO:0045229external encapsulating structure organization and biogenesis0.0176305288148319
GO:0005343organic acid:sodium symporter activity0.0277605898821897
GO:0015296anion:cation symporter activity0.0277605898821897
GO:0050909sensory perception of taste0.0283187928199733
GO:0050906detection of stimulus during sensory perception0.0294598247841548
GO:0008067metabotropic glutamate, GABA-B-like receptor activity0.0347493661867851
GO:0051606detection of stimulus0.0465069031538146
GO:0015370solute:sodium symporter activity0.0468551172588897
GO:0008066glutamate receptor activity0.0468551172588897
GO:0031402sodium ion binding0.0468551172588897
GO:0046943carboxylic acid transmembrane transporter activity0.0468551172588897
GO:0005342organic acid transmembrane transporter activity0.0468551172588897
GO:0046982protein heterodimerization activity0.0479073059231907



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>

Disease
Ontology termp-valuen
carcinoma7.15e-16106
cell type cancer1.10e-09143
adenocarcinoma8.40e-0725


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
RAD21#588544.142013558182530.01132276475674040.0415289983645026



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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