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Coexpression cluster:C735

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Full id: C735_hippocampus_medial_olfactory_amygdala_occipital_insula_middle



Phase1 CAGE Peaks

Hg19::chr11:133197324..133197336,-p@chr11:133197324..133197336
-
Hg19::chr11:94134180..94134196,-p1@AB384231
Hg19::chr11:94134299..94134309,-p2@AB384231
Hg19::chr12:118406198..118406208,-p17@KSR2
Hg19::chr12:41221619..41221633,+p7@CNTN1
Hg19::chr19:18309621..18309636,-p@chr19:18309621..18309636
-
Hg19::chr19:47763015..47763035,+p@chr19:47763015..47763035
+
Hg19::chr19:54462405..54462474,+p@chr19:54462405..54462474
+
Hg19::chr22:18592469..18592498,+p@chr22:18592469..18592498
+
Hg19::chr8:144241413..144241426,-p3@LY6H
Hg19::chr9:13165441..13165450,-p20@MPDZ


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0008289lipid binding0.00157559168692717
GO:0048503GPI anchor binding0.00330020851256108
GO:0035091phosphoinositide binding0.00872259388036306
GO:0005543phospholipid binding0.0115574480250189
GO:0005624membrane fraction0.0381913489365482
GO:0000267cell fraction0.048973045288048
GO:0019717synaptosome0.048973045288048



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
central nervous system3.28e-5082
neural tube1.87e-4957
neural rod1.87e-4957
future spinal cord1.87e-4957
neural keel1.87e-4957
regional part of nervous system3.81e-4894
nervous system3.81e-4894
regional part of brain1.13e-4059
regional part of forebrain7.65e-4041
forebrain7.65e-4041
future forebrain7.65e-4041
adult organism1.02e-39115
brain1.54e-3969
future brain1.54e-3969
anterior neural tube1.59e-3842
neurectoderm5.74e-3790
telencephalon3.08e-3534
gray matter3.69e-3534
brain grey matter3.69e-3534
neural plate4.54e-3586
presumptive neural plate4.54e-3586
regional part of telencephalon4.83e-3433
cerebral hemisphere2.50e-3332
regional part of cerebral cortex4.05e-2822
neocortex1.06e-2520
cerebral cortex1.12e-2525
pallium1.12e-2525
pre-chordal neural plate2.69e-2461
ectoderm1.27e-21173
presumptive ectoderm1.27e-21173
ectoderm-derived structure4.15e-20169
anterior region of body2.38e-17129
craniocervical region2.38e-17129
head8.24e-17123
tube1.88e-15194
posterior neural tube8.92e-1215
chordal neural plate8.92e-1215
basal ganglion4.26e-119
nuclear complex of neuraxis4.26e-119
aggregate regional part of brain4.26e-119
collection of basal ganglia4.26e-119
cerebral subcortex4.26e-119
nucleus of brain7.53e-119
neural nucleus7.53e-119
temporal lobe1.03e-107
anatomical conduit4.12e-10241
segmental subdivision of hindbrain6.92e-0912
hindbrain6.92e-0912
presumptive hindbrain6.92e-0912
anatomical cluster7.47e-09286
gyrus7.87e-096
telencephalic nucleus9.33e-097
segmental subdivision of nervous system5.67e-0813
epithelium9.75e-08309
embryo1.17e-07612
limbic system1.70e-075
cell layer1.91e-07312
parietal lobe1.95e-075
brainstem3.36e-078
occipital lobe3.43e-075


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.