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Coexpression cluster:C4563

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Full id: C4563_non_Mast_chronic_acute_granulocyte_myelodysplastic_CD34



Phase1 CAGE Peaks

Hg19::chr6:135502408..135502459,+p2@MYB
Hg19::chr6:135502472..135502489,+p3@MYB
Hg19::chr6:135502501..135502546,+p1@MYB


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br><br>disease_data<br>


Disease
Ontology termp-valuen
hematologic cancer3.04e-2851
immune system cancer3.04e-2851
leukemia7.39e-2639
myeloid leukemia2.81e-2131
organ system cancer1.85e-16137
cancer1.53e-14235
disease of cellular proliferation1.04e-13239


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90536.336201576962630.003930750035764890.0190958974316331
E2F1#186934.907389214879320.008460985347239390.0327340933017349
E2F4#1874312.66806031528440.0004917987006298980.00438699730911223
E2F6#187635.017155731697390.00791769806886330.0324014132915643
EGR1#195834.988179094810140.008056488137383440.032218240334668
FOXA1#3169311.08141974938550.000734755275698670.00583596518660684
HDAC2#3066313.41562023662630.0004140761399857210.00393178452440846
HMGN3#932438.178547723350590.001827766942164210.0109098789319705
IRF1#365937.63716375356390.002244692747297240.0128647020707335
MAX#414936.452555509007120.003721913834265510.0187295441330276
NRF1#4899312.21027944771090.0005492172401020010.004731867624073
SRF#6722313.79717826216780.0003806615025800190.00376191395419707
ZBTB7A#5134137.35190930787590.002516255860282270.0140788195538423
ZNF263#1012738.221841637010680.001799043925565870.0110006058865442



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.