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Coexpression cluster:C412

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Full id: C412_serous_breast_papillotubular_ductus_seminal_kidney_clear



Phase1 CAGE Peaks

Hg19::chr11:13974012..13974015,-p@chr11:13974012..13974015
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Hg19::chr11:61897513..61897534,+p4@INCENP
Hg19::chr11:61897578..61897585,+p10@INCENP
Hg19::chr16:34981388..34981402,+p1@ENST00000516373
Hg19::chr17:37809300..37809309,+p13@STARD3
Hg19::chr17:37856184..37856193,+p6@ERBB2
Hg19::chr17:37856299..37856329,+p1@ERBB2
Hg19::chr19:23732661..23732689,+p@chr19:23732661..23732689
+
Hg19::chr1:159836049..159836056,+p@chr1:159836049..159836056
+
Hg19::chr1:180240503..180240504,-p@chr1:180240503..180240504
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Hg19::chr20:30943898..30943899,-p@chr20:30943898..30943899
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Hg19::chr20:39536980..39536981,+p@chr20:39536980..39536981
+
Hg19::chr2:22353663..22353666,+p@chr2:22353663..22353666
+
Hg19::chr2:235157093..235157098,+p@chr2:235157093..235157098
+
Hg19::chr3:168726935..168726936,-p@chr3:168726935..168726936
-
Hg19::chr5:173377093..173377094,-p@chr5:173377093..173377094
-
Hg19::chr6:11768690..11768702,-p@chr6:11768690..11768702
-
Hg19::chr6:11768713..11768725,-p@chr6:11768713..11768725
-
Hg19::chr6:42724431..42724435,+p@chr6:42724431..42724435
+
Hg19::chr7:119683648..119683658,+p@chr7:119683648..119683658
+
Hg19::chr7:150006580..150006590,+p6@LRRC61
Hg19::chr7:150037547..150037552,-p10@RARRES2
Hg19::chr7:154497207..154497243,-p@chr7:154497207..154497243
-
Hg19::chr8:101588316..101588317,-p1@AK127517
Hg19::chr9:88496176..88496181,+p@chr9:88496176..88496181
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0033087negative regulation of immature T cell proliferation0.00747674555516307
GO:0033080immature T cell proliferation in the thymus0.00747674555516307
GO:0033079immature T cell proliferation0.00747674555516307
GO:0033083regulation of immature T cell proliferation0.00747674555516307
GO:0033088negative regulation of immature T cell proliferation in the thymus0.00747674555516307
GO:0033084regulation of immature T cell proliferation in the thymus0.00747674555516307
GO:0005006epidermal growth factor receptor activity0.0168202015612282
GO:0005721centric heterochromatin0.0168202015612282
GO:0043125ErbB-3 class receptor binding0.0199335866525098
GO:0008045motor axon guidance0.0224236346827391
GO:0033077T cell differentiation in the thymus0.0313723029195121
GO:0007528neuromuscular junction development0.0313723029195121
GO:0016101diterpenoid metabolic process0.0313723029195121
GO:0017127cholesterol transporter activity0.0313723029195121
GO:0001523retinoid metabolic process0.0313723029195121
GO:0006700C21-steroid hormone biosynthetic process0.0313723029195121
GO:0004716receptor signaling protein tyrosine kinase activity0.0313723029195121
GO:0015248sterol transporter activity0.0313723029195121
GO:0030879mammary gland development0.0313723029195121
GO:0006721terpenoid metabolic process0.0313723029195121
GO:0008207C21-steroid hormone metabolic process0.0346241181710792
GO:0015485cholesterol binding0.0346241181710792
GO:0050679positive regulation of epithelial cell proliferation0.035064301385311
GO:0000792heterochromatin0.0373314928407595
GO:0008289lipid binding0.0413396373469942
GO:0007422peripheral nervous system development0.0413396373469942
GO:0042552myelination0.0417436404705552
GO:0032934sterol binding0.0417436404705552
GO:0031902late endosome membrane0.0417436404705552
GO:0050678regulation of epithelial cell proliferation0.0417436404705552
GO:0007272ensheathment of neurons0.0417436404705552
GO:0008366axon ensheathment0.0417436404705552
GO:0050673epithelial cell proliferation0.0417436404705552
GO:0042129regulation of T cell proliferation0.0417436404705552
GO:0000910cytokinesis0.0417436404705552
GO:0045765regulation of angiogenesis0.0417436404705552
GO:0042098T cell proliferation0.0417436404705552
GO:0050808synapse organization and biogenesis0.0417436404705552
GO:0001508regulation of action potential0.0417436404705552
GO:0044255cellular lipid metabolic process0.0417436404705552
GO:0030217T cell differentiation0.0417436404705552
GO:0048741skeletal muscle fiber development0.0417436404705552
GO:0050670regulation of lymphocyte proliferation0.0417436404705552
GO:0032944regulation of mononuclear cell proliferation0.0417436404705552
GO:0048747muscle fiber development0.0417436404705552
GO:0042446hormone biosynthetic process0.0418053836348106
GO:0006720isoprenoid metabolic process0.0428126721177308
GO:0048732gland development0.0428491605705884
GO:0006839mitochondrial transport0.043793229394858
GO:0005770late endosome0.0446891448334533
GO:0032943mononuclear cell proliferation0.0446891448334533
GO:0019748secondary metabolic process0.0446891448334533
GO:0046651lymphocyte proliferation0.0446891448334533
GO:0007411axon guidance0.0463340700446233
GO:0007059chromosome segregation0.0470624258525105
GO:0050863regulation of T cell activation0.0470624258525105
GO:0006629lipid metabolic process0.0480588986131011
GO:0030098lymphocyte differentiation0.0492722668622572
GO:0043406positive regulation of MAP kinase activity0.0497624591336918
GO:0007519skeletal muscle development0.0497624591336918
GO:0016324apical plasma membrane0.0497624591336918



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell2.33e-19254
embryonic cell2.53e-13248
endodermal cell6.32e-0959
endo-epithelial cell1.79e-0843
Uber Anatomy
Ontology termp-valuen
multi-tissue structure1.33e-17347
multi-cellular organism4.52e-17659
organism subdivision3.01e-15365
mesenchyme9.19e-14238
entire embryonic mesenchyme9.19e-14238
endoderm-derived structure2.34e-13169
endoderm2.34e-13169
presumptive endoderm2.34e-13169
organ3.77e-13511
anatomical system2.15e-12625
anatomical group4.24e-12626
embryo4.14e-11612
trunk8.05e-11216
digestive system1.12e-10155
digestive tract1.12e-10155
primitive gut1.12e-10155
organ part4.14e-10219
primordium6.35e-10168
cell layer7.77e-10312
epithelium1.20e-09309
subdivision of digestive tract2.29e-09129
endodermal part of digestive tract2.29e-09129
mixed endoderm/mesoderm-derived structure2.45e-09130
subdivision of trunk2.53e-09113
embryonic structure3.75e-09605
developing anatomical structure3.75e-09605
anatomical cluster4.62e-09286
reproductive structure5.87e-0959
reproductive system5.87e-0959
germ layer7.90e-09604
embryonic tissue7.90e-09604
presumptive structure7.90e-09604
epiblast (generic)7.90e-09604
immaterial anatomical entity2.41e-08126
compound organ4.17e-0869
extraembryonic membrane7.75e-0814
membranous layer7.75e-0814
female organism1.06e-0741
female reproductive organ1.95e-0737
female reproductive system1.95e-0737
reproductive organ1.98e-0748
anatomical conduit2.83e-07241
trunk region element3.11e-07107
epithelial tube3.33e-07118
renal system4.15e-0745
anatomical space4.82e-07104
trunk mesenchyme5.07e-07143
urinary system structure5.80e-0744
organ component layer9.46e-0757
Disease
Ontology termp-valuen
carcinoma2.77e-08106
adenocarcinoma3.89e-0825


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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