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Coexpression cluster:C1584

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Full id: C1584_Endothelial_prostate_Gingival_Prostate_lens_Urothelial_Mallassezderived



Phase1 CAGE Peaks

Hg19::chr10:4720273..4720297,-p1@LOC100216001
Hg19::chr10:4720301..4720325,-p1@ENST00000449712
Hg19::chr10:4720333..4720350,-p3@ENST00000430998
Hg19::chr10:4720356..4720386,-p2@ENST00000430998
Hg19::chr10:4720389..4720416,-p1@ENST00000430998


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
vessel1.19e-2069
vasculature1.99e-1979
vascular system1.99e-1979
blood vessel5.84e-1960
epithelial tube open at both ends5.84e-1960
blood vasculature5.84e-1960
vascular cord5.84e-1960
splanchnic layer of lateral plate mesoderm4.28e-1884
epithelial tube2.51e-17118
unilaminar epithelium7.57e-16138
endothelium2.44e-1518
blood vessel endothelium2.44e-1518
cardiovascular system endothelium2.44e-1518
circulatory system2.24e-14113
simple squamous epithelium3.56e-1422
cardiovascular system3.71e-14110
artery9.48e-1442
arterial blood vessel9.48e-1442
arterial system9.48e-1442
systemic artery3.50e-1233
systemic arterial system3.50e-1233
aorta5.91e-1221
aortic system5.91e-1221
trunk9.21e-12216
squamous epithelium3.29e-1125
mesenchyme3.27e-10238
entire embryonic mesenchyme3.27e-10238
anatomical system1.93e-09625
anatomical group2.68e-09626
surface structure4.17e-0995
endoderm-derived structure6.75e-09169
endoderm6.75e-09169
presumptive endoderm6.75e-09169
multilaminar epithelium7.53e-0982
endothelial tube1.37e-089
arterial system endothelium1.37e-089
endothelium of artery1.37e-089
trunk mesenchyme1.69e-08143
multi-cellular organism1.74e-08659
mesoderm2.64e-08448
mesoderm-derived structure2.64e-08448
presumptive mesoderm2.64e-08448
anatomical conduit6.00e-08241
organism subdivision1.57e-07365
somite2.21e-0783
paraxial mesoderm2.21e-0783
presomitic mesoderm2.21e-0783
presumptive segmental plate2.21e-0783
trunk paraxial mesoderm2.21e-0783
presumptive paraxial mesoderm2.21e-0783
digestive system2.69e-07155
digestive tract2.69e-07155
primitive gut2.69e-07155
anatomical cluster3.61e-07286
cell layer8.20e-07312
epithelium9.71e-07309


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203356.77394172622327.00901578206049e-050.00110643077276695
FOS#235358.99795530889441.69470025615156e-050.000388397630134327
FOSL2#2355516.93020060456177.18315284751475e-073.20461896728575e-05
FOXA1#3169511.08141974938555.98116883436141e-060.000178680575483945
GATA2#2624512.7449317335542.9719152914525e-060.000100970677008461
GATA3#2625316.34190981432360.0004678865195089230.00430117069016745
JUN#3725512.51282919233633.25800591331781e-060.00010898875066656
JUND#372756.994663941871035.97069468343598e-050.000982934082666094
MAFF#23764556.31535648994521.76021388477016e-091.53965643141968e-07
MAFK#7975527.10073313782996.83095404221442e-084.14777912334205e-06
NR3C1#2908514.9730233311731.32777388277837e-065.23485755166062e-05
STAT3#6774510.51946499715427.759040745861e-060.000220083230976908
TCF7L2#6934510.77017656313736.89693748574565e-060.00019936597123548



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.