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Coexpression cluster:C457

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Full id: C457_salivary_Prostate_oral_Small_Keratinocyte_Urothelial_Mammary



Phase1 CAGE Peaks

Hg19::chr6:56480719..56480734,-p@chr6:56480719..56480734
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Hg19::chr6:56483141..56483154,-p@chr6:56483141..56483154
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Hg19::chr6:56483724..56483742,-p57@DST
Hg19::chr6:56483961..56483984,-p33@DST
Hg19::chr6:56484092..56484104,-p63@DST
Hg19::chr6:56484207..56484218,-p79@DST
Hg19::chr6:56484346..56484362,-p29@DST
Hg19::chr6:56484382..56484393,-p76@DST
Hg19::chr6:56484469..56484489,-p38@DST
Hg19::chr6:56484495..56484517,-p31@DST
Hg19::chr6:56484521..56484552,-p23@DST
Hg19::chr6:56484616..56484636,-p@chr6:56484616..56484636
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Hg19::chr6:56484716..56484736,-p@chr6:56484716..56484736
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Hg19::chr6:56484743..56484754,-p@chr6:56484743..56484754
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Hg19::chr6:56484773..56484794,-p@chr6:56484773..56484794
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Hg19::chr6:56484963..56484989,+p@chr6:56484963..56484989
+
Hg19::chr6:56485093..56485108,-p@chr6:56485093..56485108
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Hg19::chr6:56485129..56485140,-p@chr6:56485129..56485140
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Hg19::chr6:56485148..56485166,-p@chr6:56485148..56485166
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Hg19::chr6:56485169..56485189,-p@chr6:56485169..56485189
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Hg19::chr6:56485258..56485269,-p@chr6:56485258..56485269
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Hg19::chr6:56485473..56485485,-p@chr6:56485473..56485485
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.56e-15254
endo-epithelial cell4.47e-1143
endodermal cell9.72e-1159
epithelial cell of alimentary canal1.88e-0721
Uber Anatomy
Ontology termp-valuen
organ4.91e-11511
ectoderm-derived structure1.03e-10169
ectoderm5.94e-10173
presumptive ectoderm5.94e-10173
endoderm-derived structure1.41e-09169
endoderm1.41e-09169
presumptive endoderm1.41e-09169
respiratory system3.87e-0972
head5.48e-09123
organism subdivision6.57e-09365
anterior region of body8.46e-09129
craniocervical region8.46e-09129
surface structure2.36e-0895
digestive system8.90e-08155
digestive tract8.90e-08155
primitive gut8.90e-08155
orifice9.91e-0835
organ part1.80e-07219
epithelial bud2.64e-0737
anatomical group6.17e-07626
anatomical system7.31e-07625
Disease
Ontology termp-valuen
cell type cancer1.60e-14143
carcinoma2.21e-13106
disease of cellular proliferation2.37e-11239
cancer9.42e-11235
squamous cell carcinoma2.47e-0814


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.