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Coexpression cluster:C2704

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Full id: C2704_amniotic_neuroectodermal_Cardiac_leiomyoblastoma_skin_neuroepithelioma_breast



Phase1 CAGE Peaks

Hg19::chr2:72375244..72375254,-p12@CYP26B1
Hg19::chr2:72375269..72375282,-p7@CYP26B1
Hg19::chr2:72375547..72375559,-p8@CYP26B1
Hg19::chr2:72376038..72376056,-p@chr2:72376038..72376056
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
fibroblast1.58e-0775
Uber Anatomy
Ontology termp-valuen
adult organism2.39e-18115
organism subdivision4.74e-12365
multi-cellular organism4.65e-11659
organ part1.34e-10219
cell layer2.42e-10312
organ component layer3.17e-1057
ectoderm5.99e-10173
presumptive ectoderm5.99e-10173
anatomical cluster7.75e-10286
epithelium8.59e-10309
anatomical conduit3.27e-09241
ectoderm-derived structure6.74e-09169
anterior region of body2.20e-08129
craniocervical region2.20e-08129
tube2.36e-08194
neurectoderm2.48e-0890
multi-tissue structure3.15e-08347
splanchnic layer of lateral plate mesoderm6.96e-0884
brain9.76e-0869
future brain9.76e-0869
head1.05e-07123
regional part of brain1.13e-0759
central nervous system1.17e-0782
anatomical system1.21e-07625
primary circulatory organ1.28e-0727
anatomical group1.75e-07626
neural tube2.39e-0757
neural rod2.39e-0757
future spinal cord2.39e-0757
neural keel2.39e-0757
neural plate3.53e-0786
presumptive neural plate3.53e-0786
extraembryonic membrane6.65e-0714
membranous layer6.65e-0714
regional part of nervous system8.95e-0794
nervous system8.95e-0794


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.