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Coexpression cluster:C2521

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Full id: C2521_Endothelial_heart_Fibroblast_large_acute_adipose_kidney



Phase1 CAGE Peaks

Hg19::chr1:147245407..147245417,-p5@GJA5
Hg19::chr1:147245422..147245431,-p7@GJA5
Hg19::chr1:147245435..147245444,-p8@GJA5
Hg19::chr1:147245445..147245461,-p2@GJA5


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism8.66e-53115
neural tube2.15e-1757
neural rod2.15e-1757
future spinal cord2.15e-1757
neural keel2.15e-1757
tube1.78e-16194
anatomical conduit2.63e-15241
neural plate1.17e-1386
presumptive neural plate1.17e-1386
regional part of brain4.35e-1359
neurectoderm5.01e-1390
anterior neural tube1.04e-1242
anatomical cluster1.38e-12286
telencephalon2.68e-1234
gray matter3.23e-1234
brain grey matter3.23e-1234
regional part of forebrain5.78e-1241
forebrain5.78e-1241
future forebrain5.78e-1241
regional part of telencephalon9.70e-1233
primary circulatory organ3.24e-1127
cerebral hemisphere6.24e-1132
compound organ9.07e-1169
central nervous system1.27e-1082
brain3.83e-1069
future brain3.83e-1069
splanchnic layer of lateral plate mesoderm5.62e-0984
regional part of nervous system6.61e-0994
nervous system6.61e-0994
heart1.09e-0824
primitive heart tube1.09e-0824
primary heart field1.09e-0824
anterior lateral plate mesoderm1.09e-0824
heart tube1.09e-0824
heart primordium1.09e-0824
cardiac mesoderm1.09e-0824
cardiogenic plate1.09e-0824
heart rudiment1.09e-0824
multi-cellular organism2.21e-08659
epithelium5.35e-08309
cell layer1.08e-07312
regional part of cerebral cortex1.19e-0722
neocortex1.66e-0720
basal ganglion1.72e-079
nuclear complex of neuraxis1.72e-079
aggregate regional part of brain1.72e-079
collection of basal ganglia1.72e-079
cerebral subcortex1.72e-079
brainstem1.79e-078
nucleus of brain1.96e-079
neural nucleus1.96e-079
cerebral cortex4.47e-0725
pallium4.47e-0725
pre-chordal neural plate5.49e-0761


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.