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Coexpression cluster:C2478

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Full id: C2478_testicular_chorionic_placenta_anaplastic_amniotic_choriocarcinoma_Placental



Phase1 CAGE Peaks

Hg19::chr19:1584937..1584949,-p1@M77818
Hg19::chr19:1584956..1584968,-p2@M77818
Hg19::chr3:49506374..49506387,+p15@DAG1
Hg19::chr7:97984753..97984783,-p9@BAIAP2L1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0002011morphogenesis of an epithelial sheet0.00423872249338194
GO:0005055laminin receptor activity0.00423872249338194
GO:0016011dystroglycan complex0.0112995998696127
GO:0042383sarcolemma0.0112995998696127
GO:0009653anatomical structure morphogenesis0.0112995998696127
GO:0005626insoluble fraction0.0112995998696127
GO:0016010dystrophin-associated glycoprotein complex0.0112995998696127
GO:0046847filopodium formation0.0112995998696127
GO:0030035microspike biogenesis0.0112995998696127
GO:0005605basal lamina0.0169454069541581
GO:0045121lipid raft0.0176488660653594
GO:0030031cell projection biogenesis0.0176488660653594
GO:0048856anatomical structure development0.0190571256358965
GO:0002009morphogenesis of an epithelium0.0190571256358965
GO:0005604basement membrane0.0208888706484029
GO:0044420extracellular matrix part0.0346386466874561
GO:0016043cellular component organization and biogenesis0.0349345137723753
GO:0003012muscle system process0.0349345137723753
GO:0006936muscle contraction0.0349345137723753
GO:0032502developmental process0.0349345137723753
GO:0032990cell part morphogenesis0.0374838474864422
GO:0030030cell projection organization and biogenesis0.0374838474864422
GO:0048858cell projection morphogenesis0.0374838474864422
GO:0032501multicellular organismal process0.0379629128886618
GO:0015629actin cytoskeleton0.0499693031959513



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
epithelial cell3.49e-16254
endodermal cell1.95e-1359
endo-epithelial cell9.34e-1243
germ line cell8.62e-117
germ cell8.62e-117
Disease
Ontology termp-valuen
cell type cancer5.88e-25143
carcinoma2.54e-22106
cancer5.74e-17235
disease of cellular proliferation4.31e-16239
adenocarcinoma3.02e-0825


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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