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Coexpression cluster:C2182

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Full id: C2182_Mesenchymal_Adipocyte_Hair_Preadipocyte_osteosarcoma_Saos2_normal



Phase1 CAGE Peaks

Hg19::chr12:108984003..108984016,-p@chr12:108984003..108984016
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Hg19::chr12:108985346..108985363,-p@chr12:108985346..108985363
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Hg19::chr12:108991778..108991800,-p2@TMEM119
Hg19::chr12:108991812..108991869,-p1@TMEM119


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
non-terminally differentiated cell6.08e-32180
fibroblast2.19e-2575
skin fibroblast6.63e-1323
contractile cell5.95e-1059
muscle precursor cell6.46e-1057
myoblast6.46e-1057
multi-potent skeletal muscle stem cell6.46e-1057
muscle cell1.40e-0954
preadipocyte8.49e-0912
fat cell1.65e-0815
electrically responsive cell1.85e-0760
electrically active cell1.85e-0760
Uber Anatomy
Ontology termp-valuen
organism subdivision6.99e-20365
somite6.48e-1983
paraxial mesoderm6.48e-1983
presomitic mesoderm6.48e-1983
presumptive segmental plate6.48e-1983
trunk paraxial mesoderm6.48e-1983
presumptive paraxial mesoderm6.48e-1983
dermomyotome6.49e-1570
surface structure5.16e-1495
integument2.89e-1245
integumental system2.89e-1245
multi-cellular organism2.74e-11659
multilaminar epithelium2.93e-1182
muscle tissue4.95e-1163
musculature4.95e-1163
musculature of body4.95e-1163
multi-tissue structure9.08e-11347
tissue1.15e-10787
skeletal muscle tissue1.45e-1061
striated muscle tissue1.45e-1061
myotome1.45e-1061
adult organism3.28e-10115
adipose tissue5.77e-1014
skin of body1.24e-0940
trunk mesenchyme2.12e-08143
head2.97e-08123
anterior region of body3.11e-08129
craniocervical region3.11e-08129
anatomical system3.88e-07625
anatomical group5.37e-07626
trunk6.70e-07216
ectoderm-derived structure6.82e-07169
dermis7.47e-079
dermatome7.47e-079
future dermis7.47e-079
regional part of brain9.51e-0759


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.