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Coexpression cluster:C1572

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Full id: C1572_small_pineal_smallcell_carcinoid_amygdala_peripheral_thalamus



Phase1 CAGE Peaks

Hg19::chr10:1700804..1700825,-p@chr10:1700804..1700825
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Hg19::chr10:1779648..1779662,-p6@ADARB2
Hg19::chr10:1779663..1779676,-p9@ADARB2
Hg19::chr10:1779683..1779697,-p11@ADARB2
Hg19::chr10:1779710..1779726,-p2@ADARB2


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
central nervous system3.30e-4882
neural tube1.25e-4657
neural rod1.25e-4657
future spinal cord1.25e-4657
neural keel1.25e-4657
adult organism2.97e-46115
regional part of nervous system9.43e-4694
nervous system9.43e-4694
brain8.11e-4069
future brain8.11e-4069
regional part of brain8.17e-4059
anterior neural tube5.91e-3742
regional part of forebrain1.77e-3641
forebrain1.77e-3641
future forebrain1.77e-3641
neurectoderm3.26e-3690
neural plate5.01e-3486
presumptive neural plate5.01e-3486
gray matter5.28e-3034
brain grey matter5.28e-3034
telencephalon5.33e-3034
regional part of telencephalon5.88e-2933
pre-chordal neural plate8.53e-2961
cerebral hemisphere2.36e-2832
anterior region of body2.50e-28129
craniocervical region2.50e-28129
head6.85e-27123
ectoderm5.73e-26173
presumptive ectoderm5.73e-26173
regional part of cerebral cortex1.52e-2422
ectoderm-derived structure3.77e-24169
neocortex1.18e-2220
cerebral cortex5.23e-2225
pallium5.23e-2225
posterior neural tube1.18e-1015
chordal neural plate1.18e-1015
organ part6.17e-10219
anatomical cluster7.47e-10286
basal ganglion1.10e-099
nuclear complex of neuraxis1.10e-099
aggregate regional part of brain1.10e-099
collection of basal ganglia1.10e-099
cerebral subcortex1.10e-099
temporal lobe1.37e-097
nucleus of brain2.09e-099
neural nucleus2.09e-099
larynx2.37e-099
segmental subdivision of nervous system4.17e-0913
segmental subdivision of hindbrain3.04e-0812
hindbrain3.04e-0812
presumptive hindbrain3.04e-0812
upper respiratory tract7.30e-0819
diencephalon7.92e-087
future diencephalon7.92e-087
gyrus8.42e-086
telencephalic nucleus1.53e-077
brainstem1.69e-078
tube8.01e-07194


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.