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Coexpression cluster:C1392

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Full id: C1392_lung_thyroid_chorionic_epididymis_throat_seminal_tonsil



Phase1 CAGE Peaks

Hg19::chr14:36983036..36983064,-p2@SFTA3
Hg19::chr14:36986924..36986931,-p@chr14:36986924..36986931
-
Hg19::chr1:8311992..8312003,+p@chr1:8311992..8312003
+
Hg19::chr21:46982878..46982901,-p@chr21:46982878..46982901
-
Hg19::chr3:193272639..193272672,-p3@ATP13A4
Hg19::chr3:193272673..193272701,-p1@ATP13A4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0015662ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism0.0458697078266135
GO:0042625ATPase activity, coupled to transmembrane movement of ions0.0458697078266135
GO:0042626ATPase activity, coupled to transmembrane movement of substances0.0458697078266135
GO:0043492ATPase activity, coupled to movement of substances0.0458697078266135
GO:0016820hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances0.0458697078266135
GO:0015405P-P-bond-hydrolysis-driven transmembrane transporter activity0.0458697078266135
GO:0015399primary active transmembrane transporter activity0.0458697078266135



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism3.24e-57115
neural tube1.62e-4757
neural rod1.62e-4757
future spinal cord1.62e-4757
neural keel1.62e-4757
anterior neural tube3.32e-3942
regional part of brain4.89e-3959
regional part of forebrain2.07e-3841
forebrain2.07e-3841
future forebrain2.07e-3841
central nervous system3.80e-3782
brain1.11e-3469
future brain1.11e-3469
regional part of nervous system7.56e-3394
nervous system7.56e-3394
telencephalon1.53e-3234
gray matter2.16e-3234
brain grey matter2.16e-3234
regional part of telencephalon2.01e-3133
cerebral hemisphere1.50e-3032
neural plate3.09e-3086
presumptive neural plate3.09e-3086
neurectoderm5.84e-2890
anterior region of body1.04e-26129
craniocervical region1.04e-26129
head7.91e-25123
pre-chordal neural plate1.42e-2461
cerebral cortex1.28e-2325
pallium1.28e-2325
regional part of cerebral cortex2.39e-2222
neocortex2.46e-2020
ectoderm-derived structure9.87e-20169
ectoderm1.04e-18173
presumptive ectoderm1.04e-18173
organ5.44e-16511
organ part4.47e-15219
anatomical conduit6.68e-15241
multi-tissue structure1.48e-14347
tube6.86e-14194
anatomical cluster2.13e-12286
organism subdivision2.72e-12365
multi-cellular organism4.37e-11659
embryo5.34e-11612
anatomical system1.74e-10625
anatomical group2.15e-10626
endoderm-derived structure3.01e-10169
endoderm3.01e-10169
presumptive endoderm3.01e-10169
nucleus of brain3.62e-109
neural nucleus3.62e-109
basal ganglion5.88e-109
nuclear complex of neuraxis5.88e-109
aggregate regional part of brain5.88e-109
collection of basal ganglia5.88e-109
cerebral subcortex5.88e-109
brainstem1.36e-098
posterior neural tube1.43e-0915
chordal neural plate1.43e-0915
subdivision of digestive tract1.85e-09129
endodermal part of digestive tract1.85e-09129
embryonic structure1.97e-09605
developing anatomical structure1.97e-09605
germ layer3.79e-09604
embryonic tissue3.79e-09604
presumptive structure3.79e-09604
epiblast (generic)3.79e-09604
digestive system5.67e-09155
digestive tract5.67e-09155
primitive gut5.67e-09155
temporal lobe1.26e-087
epithelium2.86e-08309
telencephalic nucleus3.79e-087
cell layer5.80e-08312
segmental subdivision of nervous system1.62e-0713
gyrus3.10e-076
diencephalon3.32e-077
future diencephalon3.32e-077
respiratory system6.38e-0772
segmental subdivision of hindbrain6.56e-0712
hindbrain6.56e-0712
presumptive hindbrain6.56e-0712


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.