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Coexpression cluster:C557

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Full id: C557_Lymphatic_Endothelial_mesothelioma_pleomorphic_Cardiac_lung_aorta



Phase1 CAGE Peaks

Hg19::chr11:108794408..108794422,+p@chr11:108794408..108794422
+
Hg19::chr11:108794429..108794441,+p@chr11:108794429..108794441
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Hg19::chr11:108794468..108794473,+p@chr11:108794468..108794473
+
Hg19::chr12:46807404..46807413,+p@chr12:46807404..46807413
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Hg19::chr1:66723029..66723041,+p54@PDE4B
Hg19::chr2:170930109..170930110,+p3@AL833423
Hg19::chr3:145968814..145968846,-p2@PLSCR4
Hg19::chr4:114238302..114238314,+p67@ANK2
Hg19::chr6:84849274..84849294,+p@chr6:84849274..84849294
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Hg19::chr7:79998842..79998855,+p25@CD36
Hg19::chr7:79998864..79998896,+p12@CD36
Hg19::chr7:79998905..79998917,+p26@CD36
Hg19::chr7:79998932..79998956,+p17@CD36
Hg19::chr7:79999026..79999038,+p31@CD36
Hg19::chr9:13446440..13446456,+p2@ENST00000428006
Hg19::chr9:13446472..13446510,+p1@ENST00000428006


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0007596blood coagulation0.00126852059183336
GO:0050817coagulation0.00126852059183336
GO:0007599hemostasis0.00126852059183336
GO:0050878regulation of body fluid levels0.00126852059183336
GO:0042060wound healing0.00126852059183336
GO:0017128phospholipid scramblase activity0.00484368389615771
GO:0017121phospholipid scrambling0.00484368389615771
GO:00041153',5'-cyclic-AMP phosphodiesterase activity0.00730233978810365
GO:0009611response to wounding0.00730233978810365
GO:0007009plasma membrane organization and biogenesis0.0110150024093571
GO:0009605response to external stimulus0.0132790655320293
GO:0005626insoluble fraction0.0141174333515346
GO:0005548phospholipid transporter activity0.0208393166100831
GO:0000267cell fraction0.0209698967234201
GO:0065008regulation of biological quality0.0218046051086361
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity0.0233904230898605
GO:0004112cyclic-nucleotide phosphodiesterase activity0.0233904230898605
GO:0006950response to stress0.0295632196082685
GO:0005200structural constituent of cytoskeleton0.0377855298244911
GO:0005319lipid transporter activity0.0405219551907834



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
anatomical cluster2.79e-36286
anatomical conduit3.07e-31241
adult organism3.84e-29115
tube4.55e-26194
splanchnic layer of lateral plate mesoderm6.92e-2384
multi-cellular organism8.46e-22659
cell layer1.35e-20312
epithelium1.39e-20309
vasculature3.83e-2079
vascular system3.83e-2079
vessel4.54e-2069
anatomical system9.01e-19625
anatomical group1.83e-18626
circulatory system3.78e-18113
cardiovascular system1.45e-17110
blood vessel3.72e-1760
epithelial tube open at both ends3.72e-1760
blood vasculature3.72e-1760
vascular cord3.72e-1760
epithelial tube1.36e-16118
multi-tissue structure1.91e-16347
organism subdivision1.40e-14365
regional part of brain1.10e-1259
neural tube1.36e-1257
neural rod1.36e-1257
future spinal cord1.36e-1257
neural keel1.36e-1257
embryo8.20e-12612
embryonic structure8.95e-12605
developing anatomical structure8.95e-12605
unilaminar epithelium1.25e-11138
artery1.99e-1142
arterial blood vessel1.99e-1142
arterial system1.99e-1142
germ layer2.04e-11604
embryonic tissue2.04e-11604
presumptive structure2.04e-11604
epiblast (generic)2.04e-11604
brain5.70e-1169
future brain5.70e-1169
central nervous system6.38e-1182
primary circulatory organ6.65e-1127
neurectoderm7.16e-1190
neural plate7.84e-1186
presumptive neural plate7.84e-1186
heart1.66e-1024
primitive heart tube1.66e-1024
primary heart field1.66e-1024
anterior lateral plate mesoderm1.66e-1024
heart tube1.66e-1024
heart primordium1.66e-1024
cardiac mesoderm1.66e-1024
cardiogenic plate1.66e-1024
heart rudiment1.66e-1024
organ2.38e-10511
systemic artery1.13e-0933
systemic arterial system1.13e-0933
anterior neural tube2.48e-0942
regional part of nervous system5.49e-0994
nervous system5.49e-0994
regional part of forebrain7.71e-0941
forebrain7.71e-0941
future forebrain7.71e-0941
endothelium8.34e-0918
blood vessel endothelium8.34e-0918
cardiovascular system endothelium8.34e-0918
muscle tissue3.49e-0863
musculature3.49e-0863
musculature of body3.49e-0863
anterior region of body4.59e-08129
craniocervical region4.59e-08129
gray matter5.98e-0834
brain grey matter5.98e-0834
head9.08e-08123
telencephalon1.37e-0734
regional part of telencephalon1.85e-0733
skeletal muscle tissue1.98e-0761
striated muscle tissue1.98e-0761
myotome1.98e-0761
squamous epithelium2.73e-0725
organ part4.17e-07219
cerebral hemisphere4.45e-0732
ectoderm6.63e-07173
presumptive ectoderm6.63e-07173
simple squamous epithelium7.61e-0722
ectoderm-derived structure9.20e-07169


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.