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Coexpression cluster:C2763

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Full id: C2763_mucinous_glioblastoma_Myoblast_myxofibrosarcoma_fibrous_Smooth_squamous



Phase1 CAGE Peaks

Hg19::chr3:98515252..98515283,-p30@DCBLD2
Hg19::chr3:98516175..98516240,-p@chr3:98516175..98516240
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Hg19::chr3:98516242..98516317,-p@chr3:98516242..98516317
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Hg19::chr3:98516353..98516419,-p@chr3:98516353..98516419
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
multi-tissue structure2.15e-15347
trunk2.68e-15216
trunk mesenchyme5.77e-15143
organism subdivision7.88e-15365
mesenchyme1.60e-14238
entire embryonic mesenchyme1.60e-14238
epithelium4.39e-14309
cell layer5.04e-14312
epithelial tube1.32e-12118
unilaminar epithelium1.42e-11138
multilaminar epithelium2.22e-1182
skeletal muscle tissue8.77e-1161
striated muscle tissue8.77e-1161
myotome8.77e-1161
multi-cellular organism1.34e-10659
anatomical system3.15e-10625
muscle tissue3.73e-1063
musculature3.73e-1063
musculature of body3.73e-1063
anatomical group3.78e-10626
dermomyotome6.42e-1070
artery9.22e-1042
arterial blood vessel9.22e-1042
arterial system9.22e-1042
embryo1.01e-09612
somite1.12e-0983
paraxial mesoderm1.12e-0983
presomitic mesoderm1.12e-0983
presumptive segmental plate1.12e-0983
trunk paraxial mesoderm1.12e-0983
presumptive paraxial mesoderm1.12e-0983
primordium2.05e-09168
embryonic structure4.33e-09605
developing anatomical structure4.33e-09605
germ layer6.52e-09604
embryonic tissue6.52e-09604
presumptive structure6.52e-09604
epiblast (generic)6.52e-09604
vasculature8.97e-0979
vascular system8.97e-0979
anatomical cluster1.34e-08286
anatomical conduit1.88e-08241
blood vessel2.80e-0860
epithelial tube open at both ends2.80e-0860
blood vasculature2.80e-0860
vascular cord2.80e-0860
systemic artery1.01e-0733
systemic arterial system1.01e-0733
splanchnic layer of lateral plate mesoderm2.34e-0784
tube2.88e-07194
vessel6.69e-0769
immaterial anatomical entity6.71e-07126
anatomical space9.97e-07104
Disease
Ontology termp-valuen
cell type cancer2.30e-12143
disease of cellular proliferation8.52e-09239
carcinoma1.34e-07106
cancer1.50e-07235
reproductive organ cancer1.79e-0729
female reproductive organ cancer5.44e-0727


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.