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Coexpression cluster:C2122

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Full id: C2122_placenta_epididymis_thyroid_skin_amniotic_tongue_parotid



Phase1 CAGE Peaks

Hg19::chr11:26593649..26593670,-p5@MUC15
Hg19::chr11:26593677..26593708,-p2@MUC15
Hg19::chr11:26593711..26593737,-p4@MUC15
Hg19::chr1:20113550..20113568,-p5@TMCO4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
endo-epithelial cell4.01e-1743
endodermal cell7.25e-1259
epithelial cell of alimentary canal7.63e-1021
Uber Anatomy
Ontology termp-valuen
endoderm-derived structure2.03e-13169
endoderm2.03e-13169
presumptive endoderm2.03e-13169
respiratory system2.80e-1172
digestive system3.21e-11155
digestive tract3.21e-11155
primitive gut3.21e-11155
mixed endoderm/mesoderm-derived structure5.03e-10130
subdivision of digestive tract7.26e-10129
endodermal part of digestive tract7.26e-10129
anatomical space1.23e-09104
oral opening2.81e-0921
orifice4.00e-0935
foregut4.01e-0898
saliva-secreting gland9.62e-086
gland of oral region9.62e-086
gland of foregut9.62e-086
oral gland9.62e-086
oral cavity9.62e-086
extraembryonic membrane2.57e-0714
membranous layer2.57e-0714
gland of gut2.69e-0710
immaterial anatomical entity3.00e-07126
mouth8.27e-0728
stomodeum8.27e-0728


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.