MCL coexpression mm9:1071

Phase1 CAGE Peaks

	Short description
Mm9::chr11:3931609..3931617,+	p3@Sec14l4
Mm9::chr12:71332401..71332444,-	p2@Pygl
Mm9::chr16:34807311..34807395,+	p@chr16:34807311..34807395 +
Mm9::chr18:39026661..39026670,-	p10@Fgf1
Mm9::chr18:39026712..39026728,-	p2@Fgf1
Mm9::chr18:39026735..39026746,-	p8@Fgf1
Mm9::chr2:34916923..34916939,-	p1@Hc

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0008184	glycogen phosphorylase activity	0.0488854428731276
GO:0004645	phosphorylase activity	0.0488854428731276
GO:0005579	membrane attack complex	0.0488854428731276
GO:0006957	complement activation, alternative pathway	0.0488854428731276
GO:0010092	specification of organ identity	0.0488854428731276
GO:0001759	induction of an organ	0.0488854428731276
GO:0031128	induction	0.0488854428731276
GO:0045168	cell-cell signaling during cell fate commitment	0.0488854428731276
GO:0050679	positive regulation of epithelial cell proliferation	0.0488854428731276

Relative expression of the co-expression cluster over median <br>Analyst:

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Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
lung	1.51e-14	14
respiratory tube	1.51e-14	14
respiration organ	1.51e-14	14
pair of lungs	1.51e-14	14
lung primordium	1.51e-14	14
lung bud	1.51e-14	14
subdivision of trunk	3.01e-14	66
trunk region element	3.80e-13	79
epithelial bud	8.34e-13	17
liver	5.85e-12	22
epithelial sac	5.85e-12	22
digestive gland	5.85e-12	22
epithelium of foregut-midgut junction	5.85e-12	22
anatomical boundary	5.85e-12	22
hepatobiliary system	5.85e-12	22
foregut-midgut junction	5.85e-12	22
hepatic diverticulum	5.85e-12	22
liver primordium	5.85e-12	22
septum transversum	5.85e-12	22
liver bud	5.85e-12	22
immaterial anatomical entity	1.07e-11	79
thoracic cavity element	3.21e-11	17
thoracic segment organ	3.21e-11	17
thoracic cavity	3.21e-11	17
thoracic segment of trunk	3.21e-11	17
respiratory primordium	3.21e-11	17
endoderm of foregut	3.21e-11	17
digestive tract diverticulum	3.26e-11	23
sac	3.26e-11	23
exocrine gland	3.46e-11	25
exocrine system	3.46e-11	25
trunk	7.68e-11	90
epithelial fold	3.31e-10	20
endo-epithelium	3.32e-09	69
foregut	1.49e-08	80

TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
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