MCL coexpression mm9:97
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0003676 | nucleic acid binding | 4.44957308349173e-05 |
| GO:0005634 | nucleus | 0.000585733164689278 |
| GO:0010468 | regulation of gene expression | 0.000585733164689278 |
| GO:0003677 | DNA binding | 0.000713198998836666 |
| GO:0045449 | regulation of transcription | 0.000713198998836666 |
| GO:0019222 | regulation of metabolic process | 0.000713198998836666 |
| GO:0019219 | regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.000713198998836666 |
| GO:0006350 | transcription | 0.000730661736320124 |
| GO:0006355 | regulation of transcription, DNA-dependent | 0.00113756538188378 |
| GO:0006351 | transcription, DNA-dependent | 0.00113756538188378 |
| GO:0032774 | RNA biosynthetic process | 0.00113756538188378 |
| GO:0031323 | regulation of cellular metabolic process | 0.00113756538188378 |
| GO:0010467 | gene expression | 0.00113756538188378 |
| GO:0006139 | nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00113756538188378 |
| GO:0050789 | regulation of biological process | 0.00113756538188378 |
| GO:0016070 | RNA metabolic process | 0.00186772743267879 |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 0.00210976937193339 |
| GO:0050794 | regulation of cellular process | 0.00341671059840876 |
| GO:0009893 | positive regulation of metabolic process | 0.00403940051718169 |
| GO:0045893 | positive regulation of transcription, DNA-dependent | 0.00417790604203939 |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | 0.00426766819051188 |
| GO:0005654 | nucleoplasm | 0.00426766819051188 |
| GO:0065007 | biological regulation | 0.00483145449891655 |
| GO:0005667 | transcription factor complex | 0.00625950687609102 |
| GO:0006366 | transcription from RNA polymerase II promoter | 0.00632245872577615 |
| GO:0045941 | positive regulation of transcription | 0.00717723439691669 |
| GO:0045935 | positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.00760975223519582 |
| GO:0048518 | positive regulation of biological process | 0.00788267700341057 |
| GO:0031981 | nuclear lumen | 0.00915414178379858 |
| GO:0043283 | biopolymer metabolic process | 0.00915414178379858 |
| GO:0045892 | negative regulation of transcription, DNA-dependent | 0.0119058234293405 |
| GO:0044451 | nucleoplasm part | 0.0145622357527369 |
| GO:0048522 | positive regulation of cellular process | 0.0145622357527369 |
| GO:0031325 | positive regulation of cellular metabolic process | 0.0145622357527369 |
| GO:0043233 | organelle lumen | 0.0149466328266534 |
| GO:0031974 | membrane-enclosed lumen | 0.0149466328266534 |
| GO:0044428 | nuclear part | 0.0167806400002146 |
| GO:0016481 | negative regulation of transcription | 0.0225479783639174 |
| GO:0003700 | transcription factor activity | 0.0225479783639174 |
| GO:0032444 | activin responsive factor complex | 0.0225479783639174 |
| GO:0031690 | adrenergic receptor binding | 0.0225479783639174 |
| GO:0031699 | beta-3 adrenergic receptor binding | 0.0225479783639174 |
| GO:0008270 | zinc ion binding | 0.0225479783639174 |
| GO:0005515 | protein binding | 0.0243541225697633 |
| GO:0045934 | negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 0.025557700194825 |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 0.0371090046752828 |
| GO:0040029 | regulation of gene expression, epigenetic | 0.0377659853919009 |
| GO:0031324 | negative regulation of cellular metabolic process | 0.0377659853919009 |
| GO:0035054 | embryonic heart tube anterior/posterior pattern formation | 0.0377659853919009 |
| GO:0031503 | protein complex localization | 0.0377659853919009 |
| GO:0005069 | transmembrane receptor protein tyrosine kinase docking protein activity | 0.0377659853919009 |
| GO:0016564 | transcription repressor activity | 0.0420489437280448 |
| GO:0007498 | mesoderm development | 0.0448731476142515 |
| GO:0009892 | negative regulation of metabolic process | 0.0457083826241915 |
| GO:0008020 | G-protein coupled photoreceptor activity | 0.0457083826241915 |
| GO:0002021 | response to dietary excess | 0.0457083826241915 |
| GO:0005123 | death receptor binding | 0.0457083826241915 |
| GO:0044246 | regulation of multicellular organismal metabolic process | 0.0457083826241915 |
| GO:0002025 | norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure | 0.0457083826241915 |
| GO:0044253 | positive regulation of multicellular organismal metabolic process | 0.0457083826241915 |
| GO:0047631 | ADP-ribose diphosphatase activity | 0.0457083826241915 |
| GO:0002024 | diet induced thermogenesis | 0.0457083826241915 |
| GO:0004939 | beta-adrenergic receptor activity | 0.0457083826241915 |
| GO:0007507 | heart development | 0.0457083826241915 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| extraembryonic cell | 1.17e-38 | 3 |
| trophoblast cell | 1.17e-38 | 3 |
| Ontology term | p-value | n |
|---|---|---|
| blastocyst | 1.17e-38 | 3 |
| blastula | 1.17e-38 | 3 |
| cleaving embryo | 1.17e-38 | 3 |
| extraembryonic membrane | 1.58e-37 | 3 |
| extraembryonic structure | 1.58e-37 | 3 |
| membranous layer | 1.58e-37 | 3 |
| placenta | 1.02e-25 | 2 |
| chorion | 1.02e-25 | 2 |
| allantois | 1.02e-25 | 2 |
| amnion | 1.55e-13 | 1 |
| embryonic uterus | 2.08e-13 | 4 |
| uterus | 2.08e-13 | 4 |
| internal female genitalia | 6.27e-11 | 5 |
| female reproductive organ | 3.51e-07 | 8 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
|
{{{tfbs_overrepresentation_jaspar}}} |
