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Coexpression cluster:C3972

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Full id: C3972_tongue_skeletal_throat_cerebellum_diaphragm_heart_medulla



Phase1 CAGE Peaks

Hg19::chr1:33336497..33336528,-p1@FNDC5
Hg19::chr1:33336544..33336561,-p2@FNDC5
Hg19::chr1:40137876..40137888,+p@chr1:40137876..40137888
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
adult organism4.35e-57114
neural tube9.09e-4456
neural rod9.09e-4456
future spinal cord9.09e-4456
neural keel9.09e-4456
regional part of nervous system8.52e-4153
regional part of brain8.52e-4153
brain1.89e-3968
future brain1.89e-3968
central nervous system1.28e-3881
nervous system4.52e-3689
neural plate1.06e-3482
presumptive neural plate1.06e-3482
neurectoderm3.17e-3386
regional part of forebrain7.34e-3041
forebrain7.34e-3041
anterior neural tube7.34e-3041
future forebrain7.34e-3041
ecto-epithelium4.06e-26104
structure with developmental contribution from neural crest2.94e-24132
telencephalon4.84e-2434
brain grey matter6.25e-2434
gray matter6.25e-2434
cerebral hemisphere1.17e-2232
regional part of telencephalon3.16e-2232
organ system subdivision5.92e-22223
pre-chordal neural plate1.74e-2161
ectoderm-derived structure1.02e-20171
ectoderm1.02e-20171
presumptive ectoderm1.02e-20171
regional part of cerebral cortex2.72e-1622
cerebral cortex2.93e-1625
pallium2.93e-1625
anatomical cluster1.84e-15373
posterior neural tube7.10e-1515
chordal neural plate7.10e-1515
tube1.13e-14192
neocortex1.15e-1420
anatomical conduit3.69e-14240
multi-tissue structure1.61e-12342
segmental subdivision of hindbrain4.59e-1212
hindbrain4.59e-1212
presumptive hindbrain4.59e-1212
cell layer7.18e-12309
epithelium1.76e-11306
segmental subdivision of nervous system7.74e-1113
organ3.27e-10503
neural nucleus2.56e-099
nucleus of brain2.56e-099
regional part of metencephalon4.44e-099
metencephalon4.44e-099
future metencephalon4.44e-099
multi-cellular organism1.13e-07656
telencephalic nucleus1.24e-077
basal ganglion2.33e-079
nuclear complex of neuraxis2.33e-079
aggregate regional part of brain2.33e-079
collection of basal ganglia2.33e-079
cerebral subcortex2.33e-079
brainstem2.61e-076
diencephalon2.89e-077
future diencephalon2.89e-077
gyrus3.76e-076


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.