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Coexpression cluster:C2559

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Full id: C2559_Keratinocyte_Small_Mammary_Bronchial_Corneal_Tracheal_Sebocyte



Phase1 CAGE Peaks

Hg19::chr1:209558506..209558510,-p@chr1:209558506..209558510
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Hg19::chr1:209795876..209795881,-p@chr1:209795876..209795881
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Hg19::chr6:43154685..43154696,+p3@CUL9
Hg19::chr6:43154700..43154713,+p2@CUL9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
endo-epithelial cell6.17e-2842
respiratory epithelial cell9.20e-2613
general ecto-epithelial cell4.12e-2414
endodermal cell8.93e-1958
epithelial cell5.69e-15253
transitional epithelial cell2.75e-144
urothelial cell2.75e-144
epithelial cell of tracheobronchial tree3.74e-149
epithelial cell of lower respiratory tract3.74e-149
ecto-epithelial cell1.88e-1234
duct epithelial cell1.12e-113
branched duct epithelial cell1.12e-113
bronchial epithelial cell1.12e-113
tracheal epithelial cell1.12e-113
tracheoblast1.12e-113
epithelial cell of Malassez1.54e-113
gingival epithelial cell2.11e-113
epidermal cell5.14e-109
stratified squamous epithelial cell8.01e-106
keratin accumulating cell8.01e-106
stratified epithelial cell8.01e-106
keratinizing barrier epithelial cell8.01e-106
epithelial fate stem cell8.01e-106
stratified epithelial stem cell8.01e-106
surface ectodermal cell8.01e-106
epithelial cell of alimentary canal1.50e-0920
mammary gland epithelial cell1.90e-084
sebum secreting cell1.95e-082
epithelial cell of sweat gland1.95e-082
epithelial cell of skin gland1.95e-082
acinar cell of sebaceous gland1.95e-082
corneal epithelial cell3.32e-082
embryonic cell1.74e-07250
keratinocyte4.07e-075
acinar cell5.98e-075
Uber Anatomy
Ontology termp-valuen
surface structure1.93e-1299
respiratory system6.33e-1274
lower respiratory tract epithelium1.12e-113
epithelium of bronchus1.12e-113
urothelium1.95e-115
gingival epithelium2.11e-113
endoderm-derived structure2.17e-11160
endoderm2.17e-11160
presumptive endoderm2.17e-11160
tracheobronchial tree1.08e-1015
lower respiratory tract1.08e-1015
transitional epithelium1.57e-096
mouth mucosa7.52e-0913
jaw skeleton9.54e-094
splanchnocranium9.54e-094
mammary gland1.90e-084
mammary bud1.90e-084
mammary ridge1.90e-084
mammary placode1.90e-084
skin gland1.95e-082
epidermis gland1.95e-082
gland of integumental system1.95e-082
sebaceous gland1.95e-082
skin sebaceous gland1.95e-082
sweat gland1.95e-082
sweat gland placode1.95e-082
sebaceous gland placode1.95e-082
trachea3.82e-087
respiratory airway3.82e-087
skin epidermis5.12e-0815
outer epithelium5.12e-0815
enveloping layer of ectoderm5.12e-0815
respiratory tract6.79e-0854
anterior region of body1.43e-0762
craniocervical region1.43e-0762
head1.81e-0756
mucosa2.42e-0720
orifice2.96e-0736
bronchus3.83e-075
primary subdivision of cranial skeletal system4.60e-075


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

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ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.