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Coexpression cluster:C1616

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Full id: C1616_Fibroblast_Small_large_Smooth_liposarcoma_Myoblast_schwannoma



Phase1 CAGE Peaks

Hg19::chr11:122051099..122051122,-p1@ENST00000533109
Hg19::chr7:130596956..130596976,-p@chr7:130596956..130596976
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Hg19::chr7:130596992..130597040,-p@chr7:130596992..130597040
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Hg19::chrX:45630639..45630663,-p@chrX:45630639..45630663
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Hg19::chrX:45630665..45630670,-p@chrX:45630665..45630670
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
multilaminar epithelium1.18e-1783
vasculature5.83e-1778
vascular system5.83e-1778
unilaminar epithelium1.10e-16148
somite1.16e-1671
presomitic mesoderm1.16e-1671
presumptive segmental plate1.16e-1671
dermomyotome1.16e-1671
trunk paraxial mesoderm1.16e-1671
epithelial vesicle1.99e-1678
dense mesenchyme tissue3.55e-1673
anatomical system4.07e-16624
paraxial mesoderm4.23e-1672
presumptive paraxial mesoderm4.23e-1672
anatomical group8.29e-16625
multi-cellular organism9.53e-16656
surface structure4.92e-1499
artery9.69e-1442
arterial blood vessel9.69e-1442
arterial system9.69e-1442
vessel9.81e-1468
skeletal muscle tissue1.65e-1362
striated muscle tissue1.65e-1362
myotome1.65e-1362
organism subdivision1.83e-13264
epithelial tube open at both ends2.75e-1359
blood vessel2.75e-1359
blood vasculature2.75e-1359
vascular cord2.75e-1359
muscle tissue7.55e-1364
musculature7.55e-1364
musculature of body7.55e-1364
cell layer2.40e-12309
epithelium9.66e-12306
trunk mesenchyme1.22e-11122
systemic artery2.54e-1133
systemic arterial system2.54e-1133
splanchnic layer of lateral plate mesoderm5.26e-1183
trunk7.95e-11199
skin of body3.13e-1041
epithelial tube9.92e-10117
integument1.04e-0946
integumental system1.04e-0946
cardiovascular system4.69e-09109
mesenchyme7.04e-09160
entire embryonic mesenchyme7.04e-09160
aorta1.27e-0821
aortic system1.27e-0821
circulatory system3.48e-08112
developing anatomical structure9.07e-08581
embryonic structure1.28e-07564
mesoderm1.38e-07315
mesoderm-derived structure1.38e-07315
presumptive mesoderm1.38e-07315
simple squamous epithelium3.13e-0722
germ layer3.35e-07560
germ layer / neural crest3.35e-07560
embryonic tissue3.35e-07560
presumptive structure3.35e-07560
germ layer / neural crest derived structure3.35e-07560
epiblast (generic)3.35e-07560
embryo6.30e-07592


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203356.77394172622327.00901578206049e-050.00110659803365475
FOS#235358.99795530889441.69470025615156e-050.000388482879833654
FOSL2#2355413.54416048364945.7953819349229e-050.000964410283463054
GATA2#262437.64695904013240.004279061879252130.0203284635920312
JUN#3725410.01026335386910.0001908531347801070.00230433647899417
JUND#372745.595731153496820.001849593301755460.0109295957249088
SMARCC1#6599217.46534372785260.005008037385199390.0233758398423615
STAT3#677436.311678998292540.007411172122460540.0306092223394494



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.