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Coexpression cluster:C301

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Full id: C301_Smooth_mesenchymal_Endothelial_Hepatic_basal_hepatic_chorionic



Phase1 CAGE Peaks

Hg19::chr7:100770328..100770393,+p1@SERPINE1
Hg19::chr7:100770399..100770412,+p6@SERPINE1
Hg19::chr7:100770418..100770430,+p8@SERPINE1
Hg19::chr7:100770437..100770464,+p3@SERPINE1
Hg19::chr7:100770466..100770499,+p2@SERPINE1
Hg19::chr7:100771725..100771774,+p7@SERPINE1
Hg19::chr7:100771785..100771826,+p5@SERPINE1
Hg19::chr7:100771827..100771882,+p4@SERPINE1
Hg19::chr7:100771879..100771926,-p@chr7:100771879..100771926
-
Hg19::chr7:100771891..100771905,+p11@SERPINE1
Hg19::chr7:100773698..100773743,+p@chr7:100773698..100773743
+
Hg19::chr7:100773764..100773799,-p@chr7:100773764..100773799
-
Hg19::chr7:100773780..100773795,+p@chr7:100773780..100773795
+
Hg19::chr7:100773800..100773832,+p@chr7:100773800..100773832
+
Hg19::chr7:100773840..100773860,+p@chr7:100773840..100773860
+
Hg19::chr7:100773872..100773904,-p@chr7:100773872..100773904
-
Hg19::chr7:100773914..100773948,-p@chr7:100773914..100773948
-
Hg19::chr7:100775170..100775232,+p2@BX649164
Hg19::chr7:100775178..100775193,-p@chr7:100775178..100775193
-
Hg19::chr7:100775233..100775309,+p1@BX649164
Hg19::chr7:100775264..100775282,-p@chr7:100775264..100775282
-
Hg19::chr7:100776967..100777011,+p@chr7:100776967..100777011
+
Hg19::chr7:100777001..100777050,-p@chr7:100777001..100777050
-
Hg19::chr7:100777029..100777041,+p@chr7:100777029..100777041
+
Hg19::chr7:100777064..100777089,+p@chr7:100777064..100777089
+
Hg19::chr7:100780263..100780339,+p9@SERPINE1
Hg19::chr7:100780319..100780345,-p@chr7:100780319..100780345
-
Hg19::chr7:100780695..100780710,+p@chr7:100780695..100780710
+
Hg19::chr7:100780724..100780737,+p@chr7:100780724..100780737
+
Hg19::chr7:100781004..100781031,+p@chr7:100781004..100781031
+
Hg19::chr7:100781252..100781342,+p@chr7:100781252..100781342
+
Hg19::chr7:100781348..100781402,+p@chr7:100781348..100781402
+
Hg19::chr7:100781477..100781548,+p@chr7:100781477..100781548
+
Hg19::chr7:100781537..100781588,-p@chr7:100781537..100781588
-
Hg19::chr7:100781614..100781656,+p@chr7:100781614..100781656
+
Hg19::chr7:100781695..100781730,+p@chr7:100781695..100781730
+
Hg19::chr7:100781793..100781808,+p@chr7:100781793..100781808
+
Hg19::chr7:100781864..100781880,+p@chr7:100781864..100781880
+
Hg19::chr7:100781903..100781920,+p@chr7:100781903..100781920
+
Hg19::chr7:100781986..100782007,+p@chr7:100781986..100782007
+
Hg19::chr7:100782368..100782400,+p@chr7:100782368..100782400
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0002020protease binding0.00302770348690518
GO:0008243plasminogen activator activity0.00302770348690518
GO:0042730fibrinolysis0.00302770348690518
GO:0030195negative regulation of blood coagulation0.00302770348690518
GO:0030193regulation of blood coagulation0.00302770348690518
GO:0050819negative regulation of coagulation0.00302770348690518
GO:0050818regulation of coagulation0.00302770348690518
GO:0045765regulation of angiogenesis0.00629194630872483
GO:0007596blood coagulation0.01171243190987
GO:0050817coagulation0.01171243190987
GO:0007599hemostasis0.01171243190987
GO:0050878regulation of body fluid levels0.01171243190987
GO:0001525angiogenesis0.01171243190987
GO:0042060wound healing0.01171243190987
GO:0048514blood vessel morphogenesis0.01171243190987
GO:0048646anatomical structure formation0.01171243190987
GO:0001568blood vessel development0.01171243190987
GO:0001944vasculature development0.01171243190987
GO:0004867serine-type endopeptidase inhibitor activity0.01171243190987
GO:0004866endopeptidase inhibitor activity0.0166902154715648
GO:0030414protease inhibitor activity0.0167785234899329
GO:0019899enzyme binding0.0183640538197232
GO:0004252serine-type endopeptidase activity0.0191781979021086
GO:0009887organ morphogenesis0.0192069939950547
GO:0008236serine-type peptidase activity0.0192069939950547
GO:0017171serine hydrolase activity0.0192069939950547
GO:0004857enzyme inhibitor activity0.0196730640919973
GO:0009611response to wounding0.0200112277337639
GO:0009605response to external stimulus0.028913263255338
GO:0004175endopeptidase activity0.0354556693747792
GO:0065008regulation of biological quality0.0407213910506945
GO:0009653anatomical structure morphogenesis0.0433399196397033
GO:0048513organ development0.0455154244672083
GO:0048519negative regulation of biological process0.0455154244672083
GO:0006950response to stress0.0455154244672083
GO:0008233peptidase activity0.0455154244672083



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
mesodermal cell8.05e-35119
non-terminally differentiated cell8.27e-31180
embryonic cell1.34e-24248
somatic cell3.76e-22591
muscle precursor cell6.24e-2257
myoblast6.24e-2257
multi-potent skeletal muscle stem cell6.24e-2257
contractile cell1.32e-2159
muscle cell9.47e-2154
smooth muscle cell1.80e-1942
smooth muscle myoblast1.80e-1942
animal cell9.81e-19679
eukaryotic cell9.81e-19679
vascular associated smooth muscle cell3.60e-1832
electrically responsive cell8.45e-1860
electrically active cell8.45e-1860
fibroblast1.06e-1675
lining cell4.52e-1357
barrier cell4.52e-1357
endothelial cell of vascular tree4.83e-1124
endothelial cell2.41e-1035
meso-epithelial cell1.02e-0944
blood vessel endothelial cell2.46e-0818
embryonic blood vessel endothelial progenitor cell2.46e-0818
native cell3.49e-08722
cardiocyte2.85e-0716
aortic smooth muscle cell3.79e-0710
squamous epithelial cell4.38e-0762
skin fibroblast5.02e-0723
multi fate stem cell6.28e-07430
Uber Anatomy
Ontology termp-valuen
vasculature1.82e-3279
vascular system1.82e-3279
epithelial tube8.04e-30118
vessel9.85e-3069
splanchnic layer of lateral plate mesoderm4.37e-2984
blood vessel6.16e-2760
epithelial tube open at both ends6.16e-2760
blood vasculature6.16e-2760
vascular cord6.16e-2760
cardiovascular system5.65e-25110
circulatory system1.60e-24113
artery1.65e-2342
arterial blood vessel1.65e-2342
arterial system1.65e-2342
trunk mesenchyme2.19e-23143
multilaminar epithelium2.90e-2382
unilaminar epithelium4.30e-23138
dermomyotome6.94e-2370
somite8.16e-2383
paraxial mesoderm8.16e-2383
presomitic mesoderm8.16e-2383
presumptive segmental plate8.16e-2383
trunk paraxial mesoderm8.16e-2383
presumptive paraxial mesoderm8.16e-2383
skeletal muscle tissue3.95e-2061
striated muscle tissue3.95e-2061
myotome3.95e-2061
muscle tissue4.45e-1963
musculature4.45e-1963
musculature of body4.45e-1963
trunk9.37e-19216
systemic artery1.58e-1833
systemic arterial system1.58e-1833
multi-cellular organism1.77e-17659
anatomical system3.92e-16625
cell layer6.54e-16312
anatomical group8.11e-16626
epithelium2.28e-15309
mesoderm9.84e-15448
mesoderm-derived structure9.84e-15448
presumptive mesoderm9.84e-15448
mesenchyme3.06e-12238
entire embryonic mesenchyme3.06e-12238
organism subdivision3.64e-12365
aorta1.18e-1121
aortic system1.18e-1121
anatomical cluster9.58e-11286
anatomical conduit1.05e-10241
germ layer1.80e-09604
embryonic tissue1.80e-09604
presumptive structure1.80e-09604
epiblast (generic)1.80e-09604
embryonic structure2.04e-09605
developing anatomical structure2.04e-09605
lateral plate mesoderm2.44e-09216
tube2.77e-09194
embryo7.23e-09612
simple squamous epithelium9.91e-0922
multi-tissue structure1.36e-08347
endothelium2.46e-0818
blood vessel endothelium2.46e-0818
cardiovascular system endothelium2.46e-0818
squamous epithelium7.01e-0825
blood vessel smooth muscle3.79e-0710
arterial system smooth muscle3.79e-0710

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
BCL11A#5333553.459689646781350.01417894842491450.049744203518749
BHLHE40#855344.377737907022190.0129508009192390.0465488074200504
CEBPB#1051112.138600582538370.01040207561906880.038617317488267
CTCF#10664182.353283285740260.0001790636655242010.00217203602365645
CTCFL#140690125.779455909943715.61284338384473e-072.5938042042715e-05
ELK4#2005124.751906826868694.33602035203446e-060.000135950053901569
EP300#2033152.478271363252390.0004713635921470570.00432742107948721
FOS#2353112.414085570678990.0042001618863850.0200009441570383
FOSL1#806176.780367268649056.77450068925307e-050.00108250011855095
FOSL2#2355124.955180664749762.81473071835762e-069.72115282720077e-05
FOXA1#3169123.243342365673790.000188668566722630.00228086079869716
HDAC2#3066134.253733245759555.22766137706847e-060.000160062071697348
HEY1#23462272.660560930825713.31152556333363e-082.22270191715296e-06
HNF4G#317453.506514942249610.01344447461371720.0474977161282055
JUN#3725113.357100515017070.0002790631827148430.00297095614062747
JUNB#372685.972806372648034.70071774143001e-050.000822204421700232
NR3C1#2908114.017152601046435.66273002737155e-050.000949141167274365
POLR2A#5430412.147453176558072.44859392948639e-144.09165922242606e-12
PRDM1#639619.29233499182356.7551613882104e-073.05942020912102e-05
RAD21#5885133.283303430266648.21445987108688e-050.00123546943328981
SIRT6#51548622.4836688765892.77986037044944e-071.40934872441441e-05
SMARCC1#659988.519679867245163.66022406923874e-060.000120135179625149
SMC3#912682.935596652669820.0050164072030320.0234128145809295
STAT3#6774102.565723170037620.004261264991781040.0202734263154437
TAL1#688685.82802276632985.58419897508093e-050.000942939622891637
TCF7L2#6934123.152246798967030.000246461806644940.00267987762875491
ZBTB7A#51341173.048352639850981.06276796092639e-050.000276036864141236



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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