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Coexpression cluster:C613

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Full id: C613_CD4_CD19_CD8_Natural_CD14_immature_Peripheral



Phase1 CAGE Peaks

Hg19::chr10:120514851..120514864,+p@chr10:120514851..120514864
+
Hg19::chr11:66445589..66445601,+p@chr11:66445589..66445601
+
Hg19::chr12:16035195..16035237,-p5@EPS8
Hg19::chr15:63796007..63796022,-p@chr15:63796007..63796022
-
Hg19::chr17:7386814..7386828,+p@chr17:7386814..7386828
+
Hg19::chr19:14116676..14116682,+p@chr19:14116676..14116682
+
Hg19::chr1:176176478..176176481,+p2@ENST00000456125
Hg19::chr1:179335173..179335190,+p4@AXDND1
Hg19::chr2:157198321..157198340,+p@chr2:157198321..157198340
+
Hg19::chr2:157198353..157198377,+p@chr2:157198353..157198377
+
Hg19::chr2:198318580..198318624,-p1@AK096309
Hg19::chr3:185655763..185655783,-p1@TRA2B
Hg19::chr5:40679504..40679537,+p3@PTGER4
Hg19::chr6:43192303..43192348,+p@chr6:43192303..43192348
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0004957prostaglandin E receptor activity0.0246190848913119
GO:0030278regulation of ossification0.0246190848913119
GO:0004955prostaglandin receptor activity0.0246190848913119
GO:0046850regulation of bone remodeling0.0246190848913119
GO:0004954prostanoid receptor activity0.0246190848913119
GO:0004953icosanoid receptor activity0.0246190848913119
GO:0007173epidermal growth factor receptor signaling pathway0.0257868660157688
GO:0005070SH3/SH2 adaptor activity0.0334876079256093
GO:0060090molecular adaptor activity0.0349427208736638
GO:0007188G-protein signaling, coupled to cAMP nucleotide second messenger0.0349427208736638
GO:0019933cAMP-mediated signaling0.0349427208736638
GO:0001503ossification0.0349427208736638
GO:0031214biomineral formation0.0349427208736638
GO:0030674protein binding, bridging0.0349427208736638
GO:0046849bone remodeling0.0349427208736638
GO:0048771tissue remodeling0.0358204378027972
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messenger0.0369769702662953
GO:0019935cyclic-nucleotide-mediated signaling0.0369769702662953
GO:0007166cell surface receptor linked signal transduction0.0477975200649953



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

Cell Type
Ontology termp-valuen
hematopoietic stem cell4.67e-47172
angioblastic mesenchymal cell4.67e-47172
leukocyte5.55e-44140
hematopoietic cell1.56e-43182
hematopoietic oligopotent progenitor cell4.71e-43165
hematopoietic multipotent progenitor cell4.71e-43165
nongranular leukocyte3.44e-35119
hematopoietic lineage restricted progenitor cell4.78e-35124
classical monocyte2.27e-2545
CD14-positive, CD16-negative classical monocyte6.10e-2542
myeloid cell5.53e-23112
common myeloid progenitor5.53e-23112
myeloid leukocyte1.27e-1976
lymphocyte9.14e-1953
common lymphoid progenitor9.14e-1953
lymphoid lineage restricted progenitor cell1.82e-1852
granulocyte monocyte progenitor cell2.07e-1771
macrophage dendritic cell progenitor9.48e-1665
myeloid lineage restricted progenitor cell1.94e-1570
mesenchymal cell4.99e-15358
monopoietic cell9.51e-1563
monocyte9.51e-1563
monoblast9.51e-1563
promonocyte9.51e-1563
connective tissue cell1.27e-14365
motile cell8.86e-14390
T cell4.49e-1025
pro-T cell4.49e-1025
native cell6.65e-10722
mature alpha-beta T cell6.22e-0918
alpha-beta T cell6.22e-0918
immature T cell6.22e-0918
mature T cell6.22e-0918
immature alpha-beta T cell6.22e-0918
stem cell1.73e-08444
multi fate stem cell2.61e-08430
lymphocyte of B lineage6.70e-0824
pro-B cell6.70e-0824
somatic stem cell7.84e-08436
B cell1.35e-0714
Uber Anatomy
Ontology termp-valuen
hematopoietic system8.67e-18102
blood island8.67e-18102
bone marrow1.52e-1580
connective tissue1.44e-14375
bone element1.67e-1486
hemolymphoid system9.52e-14112
skeletal element9.63e-10101
skeletal system9.63e-10101
immune system3.80e-09115
Disease
Ontology termp-valuen
cancer1.87e-11235
disease of cellular proliferation1.12e-10239
organ system cancer4.43e-07137


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CCNT2#90573.168100788481320.002983097937573470.0158792948777898
E2F1#186982.804222408502470.002716619611129390.0149216911521375
E2F4#187465.429168706550470.0004158449263717840.00391229873573036
E2F6#1876103.583682665498134.45981311345876e-050.000790392706187883
EGR1#195893.206686560949370.0003889267057646490.00380506943544301
ELF1#1997103.041498542005380.0001960883233653430.00235773295002913
ELK4#200544.638766188133720.008733913817853870.0331815651226934
ETS1#211396.254203449987221.57751348151719e-066.00415198601216e-05
FOSL2#235544.837200172731910.007541622873992410.0310889895929305
GABPB1#255384.038676477818380.0002160368143870840.0024775083845144
GTF2B#295936.845106414498050.008614109848639840.0328147438897759
GTF2F1#296265.459854661467560.0004033133552769910.00388039092692526
HEY1#23462123.462952322662042.86301377032512e-069.8423401961483e-05
HMGN3#932484.673455841914627.53694136401289e-050.00116684052640994
IRF1#365984.364093573465090.0001238143250234230.00165084186022231
JUN#372554.468867568691550.00352745885080830.0179089142443035
JUNB#372636.559421284247390.009679313046712050.0364221861028845
JUND#372762.997713117944730.009116463920820550.0344943980663205
MAX#414994.148071398647444.88080712048191e-050.000847177355585857
MXI1#460185.692326645005311.76881691091529e-050.000403700763459532
MYC#4609124.476241604236631.49722896143429e-078.42960083575398e-06
NRF1#489976.105139723855455.0447325218961e-050.000859629335706162
POLR2A#5430142.147453176558072.25331953374171e-050.000492640650584991
POU2F2#545253.252187163479470.01362351556019460.0480700814754269
REST#597864.135726592626290.001776161327137930.0109085864654489
RFX5#599354.302825295426820.004160224493762290.0198261321425526
SIN3A#25942103.863489090582242.23981931004689e-050.000490099494913026
SMARCB1#659845.215061651759260.005781759737825980.0259985019055717
SP1#666772.849190689070450.005537931113228910.0250704806040102
TAF1#6872133.104257265334911.55079831716319e-065.91108851993454e-05
TBP#6908143.706770687096391.08014255397772e-088.13330989148374e-07
TCF12#693875.317232451093210.0001225526264572570.001651519194138
TFAP2C#702253.86043878923580.006637273182023020.0283038738253768
YY1#752882.806383285630770.002702639654839410.0148660126882484
ZBTB7A#5134184.201091033071940.0001628644135476470.00202637556427242
ZNF263#1012763.523646415861720.004061029105107940.0194260898048078



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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